Stock Market Portfolio Management: A Walk-through

Stock market portfolio management has remained successful in drawing attention of number of researchers from the fields of computer science, finance and mathematics all around the world since years. Successfully managing stock market portfolio is the prime concern for investors and fund managers in the financial markets. This paper is aimed to provide a walk-through to the stock market portfolio management. This paper deals with questions like what is stock market portfolio, how to manage it, what are the objectives behind managing it, what are the challenges in managing it. As each coin has two sides, each portfolio has two elements – risk and return. Regarding this, Markowitz’s Modern Portfolio Theory, or Risk-Return Model, to manage portfolio is analyzed in detail along with its criticisms, efficient frontier, and suggested state-of-the-art enhancements in terms of various constraints and risk measures. This paper also discusses other models to manage stock market portfolio such as Capital Asset Pricing Model (CAPM) and Arbitrage Pricing Theory (APT) Model. DOI: 10.17762/ijritcc2321-8169.150613

Anterior tibial spine (ACL avulsion) fracture treated with open reduction and fixation with screw: surgical technique, functional and clinico-radiological outcomes

Background: The anterior tibial spine fracture occurs almost at a same frequency both in adolescents and in adults. These injuries are often overlooked at emergency room. Stable internal fixation requires to gain optimum function of ACL by securing its length and nascent tension. We treated anterior tibial spine (ACL avulsion) fracture patient with open reduction and screw fixation.Methods: Study of Ten patients of anterior tibial spine (ACL avulsion) fracture, with minimum of 06 months and maximum of 18 months follow up. Classification of anterior tibial spine (ACL avulsion) a fracture done by Meyer and Mckeever. All patients operated with open reduction and internal fixation with screw via medial parapatellar approach. Functional and clinical outcome measured with Lysholm knee score at final follow up.Results: We studied 10 patients with anterior tibial spine (ACL avulsion) fractrure where mean age of patient was 36.4 years. Mean radiological healing was 10.6 weeks in anterior tibial spine (ACL avulsion) fracture. We observed mean motion of knee 133 degree in anterior tibial spine (ACL avulsion) fracture. Mean Lysholm score at final follow up was 86.8.Conclusions: Open reduction for anterior tibial spine (ACL) fracture provides direct visualization with easy application of screws ultimately confers stable osteosynthesis enables to start early range of motion and further rehabilitation protocol. Open reduction internal fixation is comparative less technically demanding, less expansive and gives excellent to good results as compared to other techniques.

A prospective study of 50 cases of patella fractures treated with different modalities

Background: Fractures of patella account for 1% of all skeletal injuries. There is no universal accepted treatment for patellar fractures. After a fracture of the patella, the best results are obtained by accurate reduction and stable internal fixation. Partial or total patellectomy is generally indicated when the patella is so severely comminuted that an accurate reduction and reconstruction of the retropatellar joint surface cannot be achieved.Methods: The prospective study of 50 cases of patellar fractures was carried out at the department of orthopaedics for the period from May 2015 to December 2017. The maximum period of follow up was 18 months with a minimum period of follow up of 5 months (average 11.68 months). Operative treatment was done in patella fractures for more than 2 mm of articular displacement or 3 mm of fragment separation. Surgical options includes internal fixation with tension band wiring with k wire and partial patellectomy with extensor mechanism repair.Results: We have studied 50 patients where 7 cases were treated conservatively. In the present series 22 patients were treated with internal fixation out of which 13 patients had excellent results. 6 patients had good results. 21 patients were treated with partial patellectomy where 6 patients had excellent results, 11 patients had good and 4 patients had fair results.Conclusions: Patella should be preserved and Osteosynthesis whenever possible has better chance for excellent results. A good surgical technique, optimal operation room environment and judicious use of antibiotics will reduce the possibility of infection

Effectiveness of optimum body bias for leakage reduction in high-K CMOS circuits

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Optimum body bias constraints for leakage reduction in high-k complementary metal-oxide-semiconductor circuits

A significantly increased subthreshold leakage is observed in devices with high-k gate dielectric due to gate fringing field effects. Further, the drain to body band-to-band tunnelling leakage (BTBT) current also increases with the value of dielectric constant (k), particularly for high-k p-channel metal-oxide-semiconductor field-effect transistors (p-MOSFETs). We show that this increase with k is due to a gate-to-drain fringing field induced increase in the local electric field, across the gate overlap region of drain junction. Due to these reasons, the circuit technique of applying an optimum body bias to minimize the total leakage, is least effective in high-k p-MOSFETs. Our results also show that, because of the degraded subthreshold characteristics in high-k MOSFETs, the effectiveness of body bias in controlling the gate leakage is further reduced for scaled CMOS technologies employing high-k gate dielectric

Progressive Characterization of Visual Phenotype in Bardet-Biedl Syndrome Mutant MiceVisual Phenotype in Bardet-Biedl Syndrome Mice

Bardet-Biedl syndrome (BBS) is an archetypical ciliopathy caused by defective ciliary trafficking and consequent function. Insights gained from BBS mouse models are applicable to other syndromic and nonsyndromic retinal diseases. This progressive characterization of the visual phenotype in three BBS mouse models sets a baseline for testing therapeutic interventions. Longitudinal acquisition of electroretinograms, optical coherence tomography scans, and visual acuity using the optomotor reflex in Bbs6/Mkks, Bbs8/Ttc8, and Bbs5 knockout mice. Gene and protein expression analysis in vivo and in vitro. Complete loss of BBS5, BBS6, or BBS8 leads to different rates of retinal degeneration and visual function over time. BBS8-deficient mice showed the fastest rate of degeneration, and BBS8 seems to be required for cone photoreceptors to reach functional maturity. In contrast, the loss of BBS5 (a further BBSome component) showed very little degeneration. Loss of BBS8 versus BBS5 resulted in different physiologic responses both in vivo and in vitro. BBS6-deficient mice show a slower rate of degeneration with both rod and cone function reducing at a similar rate. The mouse models analyzed show distinct and diverging courses of degeneration upon loss of BBS5, BBS6, or BBS8, which can be used as a benchmark to test therapeutic interventions. Close consideration of the different phenotypes reveal subtle but important differences relating to their function. Because we also see differences in terms of phenotype depending on the type of visual assessment used, our data highlight the importance of using a combinatorial approach for assessment of visual function