Search for Excited Quarks in qqˉ→γγq\bar{q} \to \gamma\gamma at the LHC

If quarks are composite particles, then excited states are expected to play a r\^ole in the Large Hadron Collider phenomena. Concentrating on virtual effects, and using a large part of the CMS detection criteria, we present here a realistic examination of their effect in diphoton production at the LHC. For various luminosities, we present the 99 % confidence limit (CL) achievable in $\Lambda-M_{q*}$ parameter space where $\Lambda$ is the compositeness scale and M_{q^*} the mass of the state. For a q^* of mass 0.5 TeV, $\Lambda \leq 1.55 (2.95)$ can be excluded at 99% CL with 30 (200)${\rm fb}^{-1}$ integrated luminosity.Comment: 11 pages, 11 figure

Design and Develop of Sea Wave Power Plant

The energy of sea waves can be absorbed by wave energy converters in a variety of manners, but in every case the transferred power is highly fluctuating in several time-scales, especially the wave-to-wave or the wave group time-scales. In most devices developed or considered so far, the final product is electrical energy to be supplied to a grid. This paper discusses the use of sea wave energy with the help of oscillating column. The mechanism converts the wave energy in to electrical power by converting the oscillating motion of waves in to rotary motion. Using compression ring we can store the power produced by the impact. This stored energy can be utilized in other strokes. The sea, which covers three quarters of the world’s surface, has been little utilized to meet the peoples’ energy needs. Keywords: Wave Energy, Oscillating Column, Floating Column, Wave Spectrum, Pelton Turbine

Quark Excitations Through the Prism of Direct Photon Plus Jet at the LHC

The quest to know the structure of matter has resulted in various theoretical speculations wherein additional colored fermions are postulated. Arising either as Kaluza-Klein excitations of ordinary quarks, or as excited states in scenarios wherein the quarks themselves are composites, or even in theories with extended gauge symmetry, the presence of such fermions ($q^*$) can potentially be manifested in $\gamma + jet$ final states at the LHC. Using unitarized amplitudes and the CMS setup, we demonstrate that in the initial phase of LHC operation (with an integrated luminosity of 200 \pb^{-1}) one can discover such states for a mass upto 2.0 TeV. The discovery of a $q^*$ with a mass as large as $\sim$5 TeV can be acheived for an integrated luminosity of \sim 140 \fb^{-1}. We also comment on the feasibility of mass determination.Comment: 21 pages, 19 figure

Insecticide efficacy against Earias species infestation of okra and residue analysis of chlorantraniliprole under field conditions in India

A field study was conducted to compare the efficacy of 10 recommended insecticides against Earias spp. on okra. Three okra plots (3 m × 5 m (15 m2)) were subjected to each of the 10 insecticidal sprays applied twice at an interval of 10 days. On the third, seventh, and tenth day after each spray, percent shoot and fruit infestation and yield were calculated. All insecticides significantly reduced shoot and fruit infestation compared to the control. However, chlorantraniliprole 18.5%SC was the most effective across all time points and resulted in the highest yield. A second field study, to determine the time till the maximum residue limit (MRL—0.3 mg/kg) and the limit of quantification (LOQ—0.01 mg/kg) for both fruit and soil exposed to either the recommended (125 mL/ha) or a double strength dose (250 mL/ha) of chlorantraniliprole 18.5% SC was undertaken. MRL was reached on the same day following both doses. The LOQ was reached on the seventh and tenth day at recommended and a double strength dose, respectively. Chlorantraniliprole 18.5% SC provides effective control. However, Earias spp. resistance has been observed in other crops. Thus, constant monitoring in the field is needed to ensure its effectiveness

Monoclonal Antibodies Recognizing the Non-Tandem Repeat Regions of the Human Mucin MUC4 in Pancreatic Cancer

The MUC4 mucin is a high molecular weight, membrane-bound, and highly glycosylated protein. It is a multi-domain protein that is putatively cleaved into a large mucin-like subunit (MUC4α) and a C-terminal growth-factor like subunit (MUC4β). MUC4 plays critical roles in physiological and pathological conditions and is aberrantly overexpressed in several cancers, including those of the pancreas, cervix, breast and lung. It is also a potential biomarker for the diagnosis, prognosis and progression of several malignancies. Further, MUC4 plays diverse functional roles in cancer initiation and progression as evident from its involvement in oncogenic transformation, proliferation, inhibition of apoptosis, motility and invasion, and resistance to chemotherapy in human cancer cells. We have previously generated a monoclonal antibody 8G7, which is directed against the TR region of MUC4, and has been extensively used to study the expression of MUC4 in several malignancies. Here, we describe the generation of anti-MUC4 antibodies directed against the non-TR regions of MUC4. Recombinant glutathione-S-transferase (GST)-fused MUC4α fragments, both upstream (MUC4α-N-Ter) and downstream (MUC4α-C-Ter) of the TR domain, were used as immunogens to immunize BALB/c mice. Following cell fusion, hybridomas were screened using the aforementioned recombinant proteins ad lysates from human pancreatic cell lines. Three anti MUC4α-N-Ter and one anti-MUC4α-C-Ter antibodies were characterized by several inmmunoassays including enzyme-linked immunosorbent assay (ELISA), immunoblotting, immunofluorescene, flow cytometry and immunoprecipitation using MUC4 expressing human pancreatic cancer cell lines. The antibodies also reacted with the MUC4 in human pancreatic tumor sections in immunohistochemical analysis. The new domain-specific anti-MUC4 antibodies will serve as important reagents to study the structure-function relationship of MUC4 domains and for the development of MUC4-based diagnostics and therapeutics

Pathobiological Implications of MUC16 Expression in Pancreatic Cancer

MUC16 (CA125) belongs to a family of high-molecular weight O-glycosylated proteins known as mucins. While MUC16 is well known as a biomarker in ovarian cancer, its expression pattern in pancreatic cancer (PC), the fourth leading cause of cancer related deaths in the United States, remains unknown. The aim of our study was to analyze the expression of MUC16 during the initiation, progression and metastasis of PC for possible implication in PC diagnosis, prognosis and therapy. In this study, a microarray containing tissues from healthy and PC patients was used to investigate the differential protein expression of MUC16 in PC. MUC16 mRNA levels were also measured by RT-PCR in the normal human pancreatic, pancreatitis, and PC tissues. To investigate its expression pattern during PC metastasis, tissue samples from the primary pancreatic tumor and metastases (from the same patient) in the lymph nodes, liver, lung and omentum from Stage IV PC patients were analyzed. To determine its association in the initiation of PC, tissues from PC patients containing pre-neoplastic lesions of varying grades were stained for MUC16. Finally, MUC16 expression was analyzed in 18 human PC cell lines. MUC16 is not expressed in the normal pancreatic ducts and is strongly upregulated in PC and detected in pancreatitis tissue. It is first detected in the high-grade pre-neoplastic lesions preceding invasive adenocarcinoma, suggesting that its upregulation is a late event during the initiation of this disease. MUC16 expression appears to be stronger in metastatic lesions when compared to the primary tumor, suggesting a role in PC metastasis. We have also identified PC cell lines that express MUC16, which can be used in future studies to elucidate its functional role in PC. Altogether, our results reveal that MUC16 expression is significantly increased in PC and could play a potential role in the progression of this disease