Measurement Uncertainty in Vibration Calibration in Frequency Range of 5 Hz to 10 kHz

The paper evaluates the measurement uncertainty in realizing the secondary vibration standard at CSIR-National Physical Laboratory, India, and presents a comparison of the measurement uncertainty of secondary standard with that of primary vibration standard. The relative expanded measurement uncertainty of 0.80% to 2.2% in frequency range of 5 Hz to 10 kHz is evaluated. The measurement uncertainty so calculated is verified by comparison with the results from primary vibration calibration standard of CSIR-National Physical Laboratory, New Delhi, and SPEKTRA Schwingungstechnik und Akustik GmbH Dresden, Germany primary calibrations. The study recommends calibrating the back-to-back accelerometer with minimal uncertainty by using a primary calibrated single-ended accelerometer mounted on the top of the back-to-back transducer.The paper serves a guiding document to the calibration laboratories, industries and other stake holders in India to understand the concept of traceability in vibration measurements and formulation of uncertainty budget as per the international standard

Potential of the waste leaves of Rhododendron arboretum (Burans) for the removal Pb (II) and Cd (II) ions from waste water

In the present study, we have used the waste leaves of Rhododendron arboreum as adsorbent for the removal of Pb2+ and Cd2+ ions from waste water. The adsorbent was characterized by means of FTIR and FESEM methods. The percentage adsorption has been achieved as 67.9 %, 58.9% and 98.8% for Pb2+ and 41%, 22.4% and 86.2% for Cd2+ ions at contact time 60 minutes, dosage 1g and pH 6, respectively. The equilibrium data of adsorption were tested with Langmuir,Freundlich isotherm models, Pseudo-first order and Pseudo-second order kinetic models

Comparative study of quality of life in breast cancer patients receiving two different chemotherapy regimens using European Organization for Research and Treatment of Cancer Quality of Questionnaire-Core 30 questionnaire module; for tolerability and safety

Background: Breast cancer is one of the most frequent occurring cancers in women and burgeoning worldwide. It is the second most common malignancy in India after carcinoma of the uterine cervix. In clinical trials, quality of life (QOL) outcome measurements is an important as endpoints with improving subjects physical, emotional, and social well-being.Methods: In this study, we were evaluated the comparison of the QOL in breast cancer patients on anthracycline-based regimen (six cycles of 5-fluorouracil, adriamycin, and cyclophosphamide [FAC] for a period of 18 weeks) and taxane-containing regimen (four cycles of adriamycin and cyclophosphamide [AC] followed by four cycles of paclitaxel [PTX] for a period of 24 weeks) using European Organization for Research and Treatment of Cancer Quality of Questionnaire-Core 30.Results: During first 3 months of therapy, both treatment groups exhibited a reduction in health-related QOL (HRQOL) with no clinically significant difference between them. The effect on HRQOL was less evident 3 weeks after completing chemotherapy with HRQOL of both groups returning to near baseline scores.Conclusions: Both treatment regimens (FAC and AC → PTX [AC followed by PTX]) were equally tolerated in patients

Jaundice in adult patients above 50 years of age: a comparative study of liver function tests

Background: Diagnosis of jaundice involves a range of tests. The liver function tests are done in all to arrive at a diagnosis and then manage the case appropriately. With advancing age, the incidence of liver disease increases. Understanding these changes is important for the management of liver diseases in the elderly. We conducted this study to find the difference in mean levels of Liver enzymes in younger and older age group of patients suffering with jaundice.Methods: It was a prospective observational study. All patients admitted with jaundice in the medicine ward satisfying inclusion/exclusion criteria were enrolled. The results of liver function tests in younger age and older age participants were then compared.Results: Total 100 participants were enrolled during the study period. 53 were enrolled in group one and the rest in group two. Anorexia (90%) was the most common symptom followed by abdominal distension (54%). The total bilirubin (8.8±4.7) as well as conjugated bilirubin (3.4±2.8) were higher in group one though they were not significant statistically (p=0.10 and 0.25 respectively). Mean AST and ALT levels were much higher in group 1 and statistically significant (p values <0.004 and 0.002 respectively). Conversely the mean PT values were higher in group two (p=0.02).Conclusions: Although the symptom severity may be more in elderly, the LFTs are not deranged proportionately. So there is a need to devise separate cut offs and these have to be lower for the older age group patients with jaundice. More studies with larger sample size are required to confirm the results

A prospective open-label randomized comparative study in Alzheimer’s disease between two commonly used drugs in coastal Indian population

Background: Currently, therapy for Alzheimer’s disease (AD) is only symptomatic. Only two classes of drugs are approved by the United States Food and Drug Administration. Our study aimed at comparing efficacy and safety of memantine and donepezil in moderate to severe AD patients.Methods: Totally, 22 patients with moderate to severe AD were randomized into the 2 arms of the study. The study was divided into an initial 4 weeks for determination of onset of efficacy and subsequent 28 weeks of the treatment phase. Onset of efficacy and response was defined as >20% and >50% reduction in the mean total score of functional dementia scale (FDS) and clinical global impression scale (CGIS) from baseline to the study end, respectively.Results: Onset of efficacy on FDS and CGIS was 16.7% (mean-time 61.25 days) and 80% (mean-time 36 days) with memantine and donepezil, respectively. Response was 89.3% and 40% with memantine and Donepezil, respectively. Total reduction in FDS and CGIS score of from baseline to the study end was 39.50, 40.00, and 25.60, 27.20 with memantine and donepezil, respectively. Tolerability was 86.33% and 20% with memantine and donepezil, respectively. Anorexia, muscle cramps, constipation, headache, and insomnia, were the common side-effects and self-limiting. Safety was 100% in both groups.Conclusions: Onset of efficacy was faster with donepezil seen at 2 weeks. Response, improvement in CGIS, FDS, and tolerability were better seen with memantine at 40 weeks. Thus, in similar clinical settings, memantine can be preferred

CORRELATION BETWEEN BLOOD GROUP, AGE & GENDER WITH COVID-19 INFECTION

Background. Covid-19, conjointly referred to as severe acute metabolism syndrome appeared in December 2019 by a new Corona virus. The virus originated from Wuhan, the capital of China’s Hubei Province and unfold everywhere the globe and have become a worldwide pandemic due to lack of cure. Aim:To study the association of ABO Blood Group, Rh, Age and gender with and COVID-19 infection. Material and methods. This retrospective study was conducted after the approval college research committee of Teerthanker Mahaveer medical college and research center. The study period of this study is from 12 March 2021 to 12 March 2022. The current research included 3000 Covid-19 patients confirmed by RTPCR test and admitted in the Teerthanker Mahaveer University Hospital, Moradabad. Covid -19 positive patient’s age, gender, ABO blood group, Rh factor and personal data was collected from the medical record department. Results. The most common blood group affected was B+ (1,119, 37.3%) followed by O+ (729, 24.3%), A+ (653, 21.8%), AB+ (330, 11.0%), B- (77, 2.6%), O- (36, 1.2%), A-(36, 1.2%) and AB- (20, 0.7%). Among study population, 69 (2.3%) belonged to 1-10 years, 157 (5.2%) belonged to 11-20 years, 727 (24.2%) belonged to 21-30 years, 479 (16.0%) belonged to 31-40 years, 455 (15.2%) belonged to 41-50 years, 584 (19.5%) belonged to 51-60 years, 377 (12.6%) belonged to 61-70 years, 114 (3.8%) belonged to 71-80 years and 38 (1.3%) belonged to above 80 years. The study population consisted of 1,811 (60.4%) males and 1,189 (39.6%) females. Conclusions. The findings of this study are In our study we found that age group that was most vulnerable was 21-30 years. We also observed that Males were affected more as compared to females and the blood group that was affected most was B positive and least numbers of patients affected are of AB negative blood group

Graft-induced variations on morphological, biochemical and molecular parameters in apple (Malus x domestica Borkh.)

339-348Though grafting in plants is in practice since ages only limited information is available on the graft-induced morphological, biochemical and molecular variations. The mechanism(s) by which rootstocks influence scion vegetative growth and development, and vice versa, are not fully understood. Therefore, in the present investigation, we studied graft-induced variations in different apple stionic combinations using scion (Scarlet Gala and Red Fuji) and rootstocks (MM111, MM106, M7, M9 and M26). Under morphological variations, significant difference was found in all the parameters viz. leaf area, shoot length, internodal length and fruit characters except petiole length and fruit firmness. Likewise, significant difference was also observed in the subjected stionic combinations based on total phenolic contents, total free amino acids and peroxidase enzyme activity. These results were further validated using DNA based molecular markers SSR. However, no polymorphism was observed in both the stionic combinations at DNA level. These results imply that rootstocks may influence morphological and biochemical parameter of the scion during graft-union but it does not influence genetic constitution of scion at DNA level. Further studies at RNA or protein level are required to unravel the reasons behind these variations

Malnutrition among under Five Children in Uttarakhand

BACKGROUND: Globally more than one third of child deaths are attributable to under nutrition. Eighty percent of the world’s undernourished children live in 20 countries, with India being home to nearly 60 million children who are underweight. OBJECTIVE: This study aimed to assess malnutrition among under five children in a selected hospital of Dehradun, Uttarakhand. METHODOLOGY: A quantitative research approach was used with descriptive cross-sectional research design. Non probability convenient sampling technique was used to select 70 under five children who fulfilled the inclusion criteria. The data collection tools included Socio -demographic profile and Anthropometric assessment of the children. The data was analyzed based on objectives by using descriptive and inferential statistics. Data was analyzed using WHO anthroplus software and SPSS 21.0. RESULT: The result showed that out of 70 children 17.14% showed mild wasting, 18.57% showed moderate wasting and (21.43%) showed severe wasting. 11.43% children showed mild stunting, moderate stunting was present in 15.71% children and severe stunting was present in 27.14% children. 31.43% children were moderately underweight and 30% were severely underweight. CONCLUSION: The study concluded that majority of the children were malnourished

Vascular patterns on narrow band imaging (NBI) video bronchoscopy of lung cancer patients and its relationship with histology: an analytical cross-sectional study

Introduction: Narrow band imaging (NBI) video bronchoscopy provides better visualisation of submucosal vascular patterns in malignant airway lesions compared to white light bronchoscopy. This analytical cross-sectional study was aimed to look for any relationship between these NBI vascular patterns and the histologic type of lung cancer.Material and methods: After screening 78 patients with suspected lung cancer, 53 subjects underwent video bronchoscopy. Thirty-two patients showing abnormal bronchial mucosa or endobronchial growth with any of the NBI vascular patterns on bronchoscopy were enrolled in the study. These abnormal areas were then biopsied and sent for histologic examination.Results: NBI bronchoscopy revealed a dilated tortuous vascular pattern in 54.8% of the patients, a non-specific pattern in 32%, a dotted pattern in 9.7% and an abrupt ending vessels pattern in 3.2% of the patients. We did not find any statistically significant relationship between a dilated tortuous pattern and squamous-cell carcinoma (p = 0.48), adenocarcinoma (p = 0.667) or small-cell carcinoma (p = 1); between a dotted pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 0.54) or small-cell carcinoma (p = 1), and between an abrupt ending capillary pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 1) or small-cell carcinoma (p =1).Conclusion: No relationship exists between NBI vascular patterns and the histology of lung cancer. Endobronchial lesions showing any vascular pattern on NBI needs to be adequately sampled for proper histologic and molecular studies in lung cancer patients