Formulation and Evaluation of Piroxicam Fast Dissolving Tablets Using Direct Compression and Sublimation Method

Objective: In the present research work, fast dissolving tablets of Piroxicam were formulated by two different techniques i.e. direct compression method and sublimation method using different superdisintegrants. Methods: Twelve formulations were prepared (PXM1 to PXM12) in which first six formulation were prepared by direct compression technique and other six formulation were prepared by sublimation method by using camphor as a sublimating agent. Result and Discussion: All the formulations were subjected for precompression, post compression parameters, and shows all the data within the specific limits. Formulation PXM4 containing 5 % crospovidone showed 99.480 ± 0.291 % drug release in 20 min which was more than the drug release of rest of the formulations. The optimized formulation PXM4 was compared with the marketed formulation and it revealed that drug release of PXM4 was found to be 99.397 ± 0.751 % in 20 min, which was greater than the marketed formulation. Finally, results were statistically analysed by the application of one way ANOVA and t-test. The stability study of the optimized formulation PXM4 showed no significant changes in, drug content, disintegration time and in-vitro drug release. Conclusion: Piroxicam can be successfully prepared using direct compression technique and it will enhance the drug dissolution, which will further increase absorption and bioavailability of the drug. Keywords: Direct compression, fast dissolving tablets, sublimation, Piroxicam

Impact of E-learning activities on English as a second language proficiency among engineering cohorts of Malaysian higher education: a 7-month longitudinal study

Recent technology implementation in learning has inspired language educators to employ various e-learning techniques, strategies, and applications in their pedagogical practices while aiming at improving specific learning efficiencies of students. The current study attempts to blend e-learning activities, including blogging, video making, online exercises, and digital storyboarding, with English language teaching and explores its impact on engineering cohorts at a public university in Malaysia. The longitudinal research study used three digital applications—Voyant Tools, Lumos Text Complexity Analyzer, and Advanced Text Analyzer—to analyze the data collected through a variety of digital assignments and activities from two English language courses during the researched academic semesters. Contributing to the available literature on the significance of integrating technology innovation with language learning, the study found that implementing e-learning activities can provide substantial insights into improving the learners’ different linguistic competencies, including writing competency, reading comprehension, and vocabulary enhancement. Moreover, the implementation of such innovative technology can motivate students to engage in more peer interactivity, learning engagement, and self-directed learning.Published versio