Study of inspiratory lung function parameters in Indian children

Background: The inspiratory parameters of pulmonary function test commonly used for various purposes in clinical practice including diagnosing airway obstruction. Expiratory portion of the flow volume loop of the pulmonary function test is studied in detail. The prediction equations for expiratory parameters are available for different population. However, the reference equation for inspiratory parameters is not available in Indian context. The current study derived the prediction equation for inspiratory parameters of pulmonary function test.Methods: The current study was carried out in school going 732 healthy girls and 1377 boys aged 6-15 years in India.  The children who meet the inclusion criteria were recruited in the study after detailed medical examination by registered medical practitioner. The lung function parameters were recorded by spirometry. The multivariate regression analysis was done to develop the prediction model.Results: The prediction equation for predicting inspiratory parameter were developed. This study revealed gender-wise and geographical variation in the inspiratory parameters. Hence this study recommends to derive gender wise prediction equations. The reference equations derived in this study can be used in population with similar background.Conclusions: Use of these equations for population having similar backgrounds will help for early and accurate diagnosis of the airway abnormalities in children. The inspiratory parameter assessment shall be included in the routine assessment of respiratory patient

Implementation of Minutiae Based Fingerprint Identification System using Crossing Number Concept

Abstract: Biometric system is essentially a pattern recognition system which recognizes a person by determining the authenticity of a specific physiological (e.g., fingerprints, face, retina, iris) or behavioral (e.g., gait, signature

Phytochemical investigation and anti-Inflammatory activity of Coccinia indica wight and arn. (Cucurbitaceae) fruits

The present work was to study the anti-inflammatory activity of Coccinia indica Wight and Arn fruits belonging to family Cucurbitaceae. The fruit powder of C. indica was subjected to successive extraction with petroleum ether, chloroform, ethanol and water in a Soxhlet extractor. The ethanol extract after preliminary phytochemical investigation shown the presence of glycosides, triterpenoids, flavonoids, tannins and phenolic compounds. The anti-inflammatory activity was studied using carrageenan-induced rat paw oedema and cotton pellet granuloma at three different doses (100, 200 and 400 mg/kg b.w. p.o.) of each extract. The ethanol extract of C. indica fruits exhibited significant anti-inflammatory activity at the dose of 200 mg/kg and 400 mg/kg in both models when compared with control group. Indomethacin (10 mg/kg b.w. p.o) also showed significant anti-inflammatory activity in both models.Colegio de Farmacéuticos de la Provincia de Buenos Aire

PanGFR-HM: A Dynamic Web Resource for Pan-Genomic and Functional Profiling of Human Microbiome With Comparative Features

The conglomerate of microorganisms inhabiting various body-sites of human, known as the human microbiome, is one of the key determinants of human health and disease. Comprehensive pan-genomic and functional analysis approach for human microbiome components can enrich our understanding about impact of microbiome on human health. By utilizing this approach we developed PanGFR-HM (http://www.bioinfo.iicb.res.in/pangfr-hm/) – a novel dynamic web-resource that integrates genomic and functional characteristics of 1293 complete microbial genomes available from Human Microbiome Project. The resource allows users to explore genomic/functional diversity and genome-based phylogenetic relationships between human associated microbial genomes, not provided by any other resource. The key features implemented here include pan-genome and functional analysis of organisms based on taxonomy or body-site, and comparative analysis between groups of organisms. The first feature can also identify probable gene-loss events and significantly over/under represented KEGG/COG categories within pan-genome. The unique second feature can perform comparative genomic, functional and pathways analysis between 4 groups of microbes. The dynamic nature of this resource enables users to define parameters for orthologous clustering and to select any set of organisms for analysis. As an application for comparative feature of PanGFR-HM, we performed a comparative analysis with 67 Lactobacillus genomes isolated from human gut, oral cavity and urogenital tract, and therefore characterized the body-site specific genes, enzymes and pathways. Altogether, PanGFR-HM, being unique in its content and functionality, is expected to provide a platform for microbiome-based comparative functional and evolutionary genomics

Web visibility and research productivity of NIRF ranked universities in India: A Webometric study

This study aims to examine the website analysis of top 15 Indian universities ranked in NIRF (National Institutes Ranking Framework). The study focused on research productivity and webometric analysis which examine the domain, domain age, external and internal links, whereas all three types of web impacts of all respondent websites have been analysed. Study also examine usage of websites by stakeholder from inside and outside the country. For measuring research productivity of the respondent’s universities, researchers has approached the Scopus database and analysed the no. of papers published, total citations received and h-index of respondent’s universities. The present study used various tools like ahrefs SEO, Alexa for collection of the data and examines websites of universities of India covered in this study. Findings revealed that Anna University’s website having a highest page authority score that is 59 out of a total of 100. It was found from the study that “Anna University” having a highest web traffic, backlinks and referring domains whereas University of Delhi’s website achieved first Alexa traffic global rank while Savitribai Phule Pune University’s website achieved 1st Alexa traffic Indian rank. It was also found from the study that Bharathiar University’s website achieved first position in all three web impact factors SWIF, IWIF and EWIF. It is observed from the findings that highest research produced by Indian Institute of Science followed by University of Delhi and Manipal Academy of Higher Education.. Keyword: World Wild Web, Webometrics Analysis, Web Impact Factor, Traffic Rank, Web Evaluation, Link Analysis, Backlinks, Referring Domain, Page Authority, Alexa Rank, research productivity, h-inde

Formulation and In Vitro Characterization of Mouth Dissolving Film of Clopidogrel Hydrogen Sulphate

The purpose of the present investigation was to formulate a mouth-dispersing film of a Clopidogrel Hydrogen Sulphate dosage form for a rapid onset of action, which is very easy for administration, without the issue of swallowing and using water. The Mouth Dissolving Film of Clopidogrel Hydrogen Sulphate was prepared through the Solvent Casting Method and its in vitro characterization was evaluated. The folding endurance is 173.6 ± 0.22, and the drug content is 96.33 ± 1.15. The drug release rate of the optimized formula A4 is 96.00% in 5 min, and it was concluded according to this result that the film prepared using an HPMC E5 polymer forms superior film that offers rapid drug release

Stabilization of cutinase by covalent attachment on magnetic nanoparticles and improvement of its catalytic activity by ultrasonication

This paper reports on stabilization of serine cutinase activity by immobilizing it through cross linking with glutaraldehyde on magnetic nanoparticles (Fe-NPs) and intensification of catalytic activity by ultrasonic treatment. The optimum parameters were cross linking with 10.52 mM glutaraldehyde for 90 min using 1:2 (w/w) ratio of enzyme:Fe-NPs. The characterization of cutinase-Fe-NPs was done by different instrumental analysis. Ultrasonic power showed a beneficial effect on the activity of free and immobilized cutinase at 5.76 and 7.63 W, respectively, after 12 min. Immobilization and ultrasonic treatment led to increments in kinetic parameters (K m and V max ) along with noticeable changes in the secondary structural fractions of cutinase. Cutinase-Fe-NPs showed augmented pH (4–8) and thermal stability (40–60 °C). Considerably higher thermal inactivation kinetic constants (k d , t 1/2 and D-value) and thermodynamic constants (E d , ΔH°, ΔG° and ΔS°) highlighted superior thermostability of cutinase-Fe-NPs. Cutinase-Fe-NPs and ultrasound treated cutinase-Fe-NPs retained 61.88% and 38.76% activity during 21-day storage, and 82.82 and 80.69% activity after fifth reusability cycle, respectively.Peer reviewe

AN EFFORT TO DETERMINE BLOOD GROUP AND GENDER FROM PATTERN OF FINGER PRINTS

ABSTRACT Introduction: Two person having identical fingerprints is about one in 64 thousand millions. A reliable personal identification is critical in the subject of forensics as is faced with many situations like civil, criminal, commercial and latest in financial transaction frauds, where the question of identification becomes a matter of paramount importance. In this study we have made an effort to "study a relationship between pattern of fingerprint, gender and blood group"