Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

Objective: Assess ustekinumab efficacy (week 24/week 52) and safety (week 16/week 24/week 60) in patients with active psoriatic arthritis (PsA) despite treatment with conventional and/or biological anti-tumour necrosis factor (TNF) agents. Methods: In this phase 3, multicentre, placebo-controlled trial, 312 adults with active PsA were randomised (stratified by site, weight (≤100 kg/>100 kg), methotrexate use) to ustekinumab 45 mg or 90 mg at week 0, week 4, q12 weeks or placebo at week 0, week 4, week 16 and crossover to ustekinumab 45 mg at week 24, week 28 and week 40. At week 16, patients with <5% improvement in tender/swollen joint counts entered blinded early escape (placebo→45 mg, 45 mg→90 mg, 90 mg→90 mg). The primary endpoint was ≥20% improvement in American College of Rheumatology (ACR20) criteria at week 24. Secondary endpoints included week 24 Health Assessment Questionnaire-Disability Index (HAQ-DI) improvement, ACR50, ACR70 and ≥75% improvement in Psoriasis Area and Severity Index (PASI75). Efficacy was assessed in all patients, anti-TNF-naïve (n=132) patients and anti-TNF-experienced (n=180) patients. Results: More ustekinumab-treated (43.8% combined) than placebo-treated (20.2%) patients achieved ACR20 at week 24 (p<0.001). Significant treatment differences were observed for week 24 HAQ-DI improvement (p<0.001), ACR50 (p≤0.05) and PASI75 (p<0.001); all benefits were sustained through week 52. Among patients previously treated with ≥1 TNF inhibitor, sustained ustekinumab efficacy was also observed (week 24 combined vs placebo: ACR20 35.6% vs 14.5%, PASI75 47.1% vs 2.0%, median HAQ-DI change −0.13 vs 0.0; week 52 ustekinumab-treated: ACR20 38.9%, PASI75 43.4%, median HAQ-DI change −0.13). No unexpected adverse events were observed through week 60. Conclusions: The interleukin-12/23 inhibitor ustekinumab (45/90 mg q12 weeks) yielded significant and sustained improvements in PsA signs/symptoms in a diverse population of patients with active PsA, including anti-TNF-experienced PsA patients

Digital Transition of Newspapers in India: Dainik Jagran, Hindustan Times, and Malayala Manorama

This study situates itself at the intersection of global trends in news and journalism, and emergent practices of print media in India. Using three case studies of newspapers from different language markets, it explores how print newspapers in India are transitioning to the online space by focusing on two key questions: 1) how the expansion of the digital, both as a source of news, and the medium of distribution, is shaping the work of journalists, and 2) what different modalities of convergence are emerging in Indian newsrooms. Also, it documents the organisational re-engineering that is being attempted in order to do journalism in a space where professional editors and journalists no longer have dominance with respect to the production and distribution of content

Digital Transition of Newspapers in India: Dainik Jagran, Hindustan Times, and Malayala Manorama

This study situates itself at the intersection of global trends in news and journalism, and emergent practices of print media in India. Using three case studies of newspapers from different language markets, it explores how print newspapers in India are transitioning to the online space by focusing on two key questions: 1) how the expansion of the digital, both as a source of news, and the medium of distribution, is shaping the work of journalists, and 2) what different modalities of convergence are emerging in Indian newsrooms. Also, it documents the organisational re-engineering that is being attempted in order to do journalism in a space where professional editors and journalists no longer have dominance with respect to the production and distribution of content

Indian news media and the production of news in the age of social discovery

In this report, we examine the social media practices of six English- language news organisations based in India in the context of the country’s increasing mobile internet access and a growing number of social media users. The organisations studied include two newspapers, two broadcast news channels, and two digital-born websites. On the basis of interviews with senior editors and executives, as well as analysis of the Facebook and Twitter output of each organisation, we find: First, Facebook is more important to publishers that Twitter. This, in part because of its very large user base, but also because the company has collaborated actively with a number of Indian publishers and offers more opportunities for monetisation. Twitter, however, is still seen as an important platform for breaking news and reaching elites. Second, most organisations covered pursue an on-site strategy oriented towards driving social media referrals to their website (where content can be monetised through advertising). Third, while the majority of social posts are links to content on publishers’ websites, all publishers have been increasing the amount of native content they post, especially to Facebook. The report also contains insight into how Indian news organisations plan their social media content, what tools and data they used to measure their performances and the relationship they share with the technology giants - Facebook and Twitter - that build and control these platforms

Indian news media and the production of news in the age of social discovery

In this report, we examine the social media practices of six English- language news organisations based in India in the context of the country’s increasing mobile internet access and a growing number of social media users. The organisations studied include two newspapers, two broadcast news channels, and two digital-born websites. On the basis of interviews with senior editors and executives, as well as analysis of the Facebook and Twitter output of each organisation, we find: First, Facebook is more important to publishers that Twitter. This, in part because of its very large user base, but also because the company has collaborated actively with a number of Indian publishers and offers more opportunities for monetisation. Twitter, however, is still seen as an important platform for breaking news and reaching elites. Second, most organisations covered pursue an on-site strategy oriented towards driving social media referrals to their website (where content can be monetised through advertising). Third, while the majority of social posts are links to content on publishers’ websites, all publishers have been increasing the amount of native content they post, especially to Facebook. The report also contains insight into how Indian news organisations plan their social media content, what tools and data they used to measure their performances and the relationship they share with the technology giants - Facebook and Twitter - that build and control these platforms

Correlation and path analysis in turmeric (Curcuma longa L.)

Studies on nineteen characters of eight turmeric (Curcuma longa L.) genotyoes revealed that plant height, leaf number, number of primary fingers, number and weight of secondary fingers had positive genotypic correlation while length of primary fingers, internode length and ratio of outer and inner core of primary fingers had significant negative association with rhizome yield. The number and weight of secondary rhizomes exhibited higher positive correlation with yield than other characters. Path analysis indicated higher direct positive effect of weight of primary and mother rhizomes but insignificant correlation with rhizome yield due to higher indirect negative effect of some of the component characters. On the contrary, the number of primary fingers had the highest direct negative effect on rhizome yield, but significantly positive correlation with it, apparently due to high positive indirect effect via weight of primary and mother rhizomes and number of secondary rhizomes. The importance of plant height, leaf number, number of primary fingers, number and weight of secondary fingers as criteria for selection of bitter turmeric genotypes has been indicated. &nbsp