NASA SpaceCube Next-Generation Artificial-Intelligence Computing for STP-H9-SCENIC on ISS

Recently, Artificial Intelligence (AI) and Machine Learning (ML) capabilities have seen an exponential increase in interest from academia and industry that can be a disruptive, transformative development for future missions. Specifically, AI/ML concepts for edge computing can be integrated into future missions for autonomous operation, constellation missions, and onboard data analysis. However, using commercial AI software frameworks onboard spacecraft is challenging because traditional radiation-hardened processors and common spacecraft processors cannot provide the necessary onboard processing capability to effectively deploy complex AI models. Advantageously, embedded AI microchips being developed for the mobile market demonstrate remarkable capability and follow similar size, weight, and power constraints that could be imposed on a space-based system. Unfortunately, many of these devices have not been qualified for use in space. Therefore, Space Test Program - Houston 9 - SpaceCube Edge-Node Intelligent Collaboration (STP-H9-SCENIC) will demonstrate inflight, cutting-edge AI applications on multiple space-based devices for next-generation onboard intelligence. SCENIC will characterize several embedded AI devices in a relevant space environment and will provide NASA and DoD with flight heritage data and lessons learned for developers seeking to enable AI/ML on future missions. Finally, SCENIC also includes new CubeSat form-factor GPS and SDR cards for guidance and navigation

Host-Adaptation of Francisella tularensis Alters the Bacterium's Surface-Carbohydrates to Hinder Effectors of Innate and Adaptive Immunity

The gram-negative bacterium Francisella tularensis survives in arthropods, fresh water amoeba, and mammals with both intracellular and extracellular phases and could reasonably be expected to express distinct phenotypes in these environments. The presence of a capsule on this bacterium has been controversial with some groups finding such a structure while other groups report that no capsule could be identified. Previously we reported in vitro culture conditions for this bacterium which, in contrast to typical methods, yielded a bacterial phenotype that mimics that of the bacterium's mammalian, extracellular phase.SDS-PAGE and carbohydrate analysis of differentially-cultivated F. tularensis LVS revealed that bacteria displaying the host-adapted phenotype produce both longer polymers of LPS O-antigen (OAg) and additional HMW carbohydrates/glycoproteins that are reduced/absent in non-host-adapted bacteria. Analysis of wildtype and OAg-mutant bacteria indicated that the induced changes in surface carbohydrates involved both OAg and non-OAg species. To assess the impact of these HMW carbohydrates on the access of outer membrane constituents to antibody we used differentially-cultivated bacteria in vitro to immunoprecipitate antibodies directed against outer membrane moieties. We observed that the surface-carbohydrates induced during host-adaptation shield many outer membrane antigens from binding by antibody. Similar assays with normal mouse serum indicate that the induced HMW carbohydrates also impede complement deposition. Using an in vitro macrophage infection assay, we find that the bacterial HMW carbohydrate impedes TLR2-dependent, pro-inflammatory cytokine production by macrophages. Lastly we show that upon host-adaptation, the human-virulent strain, F. tularensis SchuS4 also induces capsule production with the effect of reducing macrophage-activation and accelerating tularemia pathogenesis in mice.F. tularensis undergoes host-adaptation which includes production of multiple capsular materials. These capsules impede recognition of bacterial outer membrane constituents by antibody, complement, and Toll-Like Receptor 2. These changes in the host-pathogen interface have profound implications for pathogenesis and vaccine development

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Archeological Investigations at the Kitchen Branch (41CP220), B. J. Horton (41CP20), and Keering (41CP21) Sites, Big Cypress Creek Basin, Camp County, Texas

This report details excavations at the Kitchen Branch site (41CP220) in Camp County, Texas. Working on behalf of the Texas Department of Transportation and Federal Highway Administration, archeologists from AmaTerra Environmental, Inc., Archeological and Environmental Consultants, LLC, Hicks & Company Environmental, Archeological, and Planning Consultants, Inc, and Coastal Environments Inc., completed National Register of Historic Places and State Antiquities Landmark eligibility testing and later data recovery investigations of components of the Kitchen Branch site. Work was conducted for compliance with the National Historic Preservation Act of 1966 (as amended) and the Antiquities Code of Texas (13 TAC 26) between 2004 and 2007 when portions of the site were proposed to be impacted by expansion of Farm to Market Road 557 at its crossing of the Kitchen Branch of Prairie Creek. Testing phase investigations (Antiquities Permit 3609) included excavation of 23 1 x 1-meter and 40 x 40-centimeter test units and 13 Gradall trenches, documenting artifacts and features attributed to Middle-Late Archaic, Woodland, and Late Caddo Titus phase occupations along with a small, minor historic (late nineteenth and early twentieth century) component. Archeologists, citing intact, buried features, lithics, ceramics, and faunal and floral materials, determined that the Titus phase site components were eligible for inclusion in the National Register of Historic Places and as a State Antiquities Landmark. Subsequent data recovery investigations (Antiquities Permit 4473) targeted the Titus phase component of the Kitchen Branch site and included geophysical survey (magnetometer, ground-penetrating radar, and electrical resistivity), block test unit excavations (167 1 x 1s in three main blocks), and mechanical and hand scraping. Approximately 4,000 prehistoric ceramic sherds, 4,400 lithic flakes, 137 projectile points, numerous other tools, and various faunal and floral materials were recovered and analyzed during both phases of investigations while archeologists documented 236 prehistoric features (and unnumbered possible post holes). To supplement the basic qualitative and quantitative data from artifact analysis, researchers collected and processed a variety of other samples including organic residue, petrographic, neutron activation, thermoluminescence dating of prehistoric ceramics and radiocarbon assays of ceramic residue and burned plant remains from the site. In addition nearly 1,000 historic artifacts were also recovered and interpreted as part of the field and analysis effort. Based on the various analyses, the primary investigated component at the Kitchen Branch is a single, small, Titus phase domestic farmstead occupied for a relatively short time during the 15th century AD. To complement the discussion of the Kitchen Branch site, this report includes brief analysis and interpretation of Titus phase ceramic vessel photographs from the Horton site (41CP20) and a small assemblage of artifacts, field notes, and photographs from the Keering site (41CP21). Both sites were investigated in 1974 by State Department of Transportation and Public Transportation archeologists in association with roadway projects and never formally reported

The Sizes and Albedos of Centaurs 2014 YY 49_{49} and 2013 NL 24_{24} from Stellar Occultation Measurements by RECON

In 2019, the Research and Education Collaborative Occultation Network (RECON) obtained multiple-chord occultation measurements of two centaur objects: 2014 YY$_{49}$ on 2019 January 28 and 2013 NL$_{24}$ on 2019 September 4. RECON is a citizen-science telescope network designed to observe high-uncertainty occultations by outer solar system objects. Adopting circular models for the object profiles, we derive a radius $r=16^{+2}_{-1}$km and a geometric albedo $p_V=0.13^{+0.015}_{-0.024}$ for 2014 YY$_{49}$, and a radius $r=66 ^{+5}_{-5}$km and geometric albedo $p_V = 0.045^{+0.006}_{-0.008}$ for 2013 NL$_{24}$. To the precision of these measurements, no atmosphere or rings are detected for either object. The two objects measured here are among the smallest distant objects measured with the stellar occultation technique. In addition to these geometric constraints, the occultation measurements provide astrometric constraints for these two centaurs at a higher precision than has been feasible by direct imaging. To supplement the occultation results, we also present an analysis of color photometry from the Pan-STARRS surveys to constrain the rotational light curve amplitudes and spectral colors of these two centaurs. We recommend that future work focus on photometry to more deliberately constrain the objects' colors and light curve amplitudes, and on follow-on occultation efforts informed by this astrometry