Evaluating the Extent and Sources of Zinc Contamination Within Eugene-Springfield Waterways

Stormwater runoff from urban and suburban areas carries pollutants, adversely affecting water quality in local waterways. In the Eugene-Springfield metro area, a specific stormwater pollutant of concern is zinc- a known herbicide, antimicrobial, and toxin at certain concentrations for aquatic organisms. Notably, zinc has been rising in water quality measurements in Eugene over the past 20 years. Using 2019 as a case study year, data aggregation revealed similar zinc concentration patterns within the waterways of Springfield and Eugene. Potential sources of zinc contamination are numerous, but findings in this study indicated the greatest proportion of zinc pollution is likely from moss control products, vehicular tire- and brake-wear, and industrial discharges. Spatial modeling of these potential sources of zinc contamination revealed stormwater basins with high zinc pollutant severity potentials, in turn distinguishing areas for future stormwater sampling efforts. This work adds to the understanding of municipal stormwater pollution in the Pacific Northwest and can lead to informed strategies for source control, minimizing zinc loading to the environment

Schwarzer Tee mit Zucker: Über Produktion von Alltäglichkeit

An Geflüchtete an Bahnhöfen ausgeschenkt, zeigt der schwarze Tee mit Zucker eine symbolische sowie imaginative Kraft und verdeutlicht prozessuale Wissensproduktionen. Ein sozialkonstruktivistischer Ansatz wird in diesem Artikel für Forschungsgebiete in der Intersektion von Nahrungs- und Migrationsforschung fruchtbar gemacht. Engl.: Given to refugees at central stations, the black tea with sugar reveals a symbolic and imaginative power and illustrates processual productions of knowledge. The article adopts a social constructivist stance and shows its value for the intersectional research field of nutrition and migration studies. &nbsp

Schwarzer Tee mit Zucker: Über Produktion von Alltäglichkeit

An Geflüchtete an Bahnhöfen ausgeschenkt, zeigt der schwarze Tee mit Zucker eine symbolische sowie imaginative Kraft und verdeutlicht prozessuale Wissensproduktionen. Ein sozialkonstruktivistischer Ansatz wird in diesem Artikel für Forschungsgebiete in der Intersektion von Nahrungs- und Migrationsforschung fruchtbar gemacht. Engl.: Given to refugees at central stations, the black tea with sugar reveals a symbolic and imaginative power and illustrates processual productions of knowledge. The article adopts a social constructivist stance and shows its value for the intersectional research field of nutrition and migration studies. &nbsp

Schwarzer Tee mit Zucker: Über Produktion von Alltäglichkeit

An Geflüchtete an Bahnhöfen ausgeschenkt, zeigt der schwarze Tee mit Zucker eine symbolische sowie imaginative Kraft und verdeutlicht prozessuale Wissensproduktionen. Ein sozialkonstruktivistischer Ansatz wird in diesem Artikel für Forschungsgebiete in der Intersektion von Nahrungs- und Migrationsforschung fruchtbar gemacht.Given to refugees at central stations, the black tea with sugar reveals a symbolic and imaginative power and illustrates processual productions of knowledge. The article adopts a social constructivist stance and shows its value for the intersectional research field of nutrition and migration studies

Tuteo o Ustedeo: un Estudio de las Formas de Tratamiento en las Publicidades de Escaparates / Tutoiement ou Vouvoiement: une Etude des Formes d\u27Adresse dans les Publicités des Vitrines

In both French and Spanish, there exist two pronouns of the second person singular form of address: tu/vous and tú/usted, respectively. While the first of each pair is typically considered the ‘informal’ pronoun of address, the second is more ‘formal’, creating a complicated distinction that every person must resolve when speaking. This project analyzes the difficulty of choosing between the two forms of address through the lens of politeness theory, emphasizing the concepts of solidarity and power as well as other important factors that contribute to this complex decision. To show how the pronouns are continuing to evolve, I study the use of the forms of address in storefront advertisements in Nantes, France and Salamanca, Spain. I explore why, in the peninsular Spanish of this region, tú is found in the majority of the storefronts studied, whereas vous dominates the advertisements of stores in metropolitan French. I ultimately conclude that while vous remains the unmarked form of address used in advertising language to maintain respectful distance between the customer and the business in France, the use of tú is clearly on the rise in Spain, indicating what we shall call a “created solidarity” between the client and the store

Only watching others making their experiences is insufficient to enhance adult neurogenesis and water maze performance in mice

In the context of television consumption and its opportunity costs the question arises how far experiencing mere representations of the outer world would have the same neural and cognitive consequences than actively interacting with that environment. Here we demonstrate that physical interaction and direct exposition are essential for the beneficial effects of environmental enrichment. In our experiment, the mice living in a simple standard cage placed in the centre of a large enriched environment only indirectly experiencing the stimulus-rich surroundings (IND) did not display increased adult hippocampal neurogenesis. In contrast, the mice living in and directly experiencing the surrounding enriched environment (DIR) and mice living in a similar enriched cage containing an uninhabited inner cage (ENR) showed enhanced neurogenesis compared to mice in control conditions (CTR). Similarly, the beneficial effects of environmental enrichment on learning performance in the Morris Water maze depended on the direct interaction of the individual with the enrichment. In contrast, indirectly experiencing a stimulus-rich environment failed to improve memory functions indicating that direct interaction and activity within the stimulus-rich environment are necessary to induce structural and functional changes in the hippocampus

Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey

Background - Current stroke guidelines recommend advanced imaging (computed tomography [CT] perfusion or magnetic resonance imaging) prior to endovascular therapy (EVT) in patients with late presentation of large vessel occlusion. Adherence to guidelines may be constrained by resources or timely access to imaging. We sought to understand the factors which influence late window imaging selection for EVT candidates with large vessel occlusion. Methods - We conducted an international survey from January to May 2022. The questions aimed to identify advanced imaging and treatment decisions based on access to imaging, time delays, and simulated patient scenarios. Results - There were 3000 invited participants and 1506 respondents, the majority (89.6%) from comprehensive stroke centers in high‐income countries. Neurointerventionalists comprised 31.8% and noninterventionalists 68.2% of respondents. Overall, 70.7% reported routine use of advanced imaging for late EVT selection, and 63.6% reported its usage in every case. There was greater availability of advanced imaging in comprehensive stroke centers versus primary stroke centers (67.0% versus 33.7%; P Conclusion - Current guidelines for imaging late window EVT candidates are inconsistent with imaging decisions by physicians. Most respondents consider an imaging delay of greater than 20 minutes unacceptable. Access to advanced imaging was greater in comprehensive stroke centers and high‐income countries. In the case of limited access most respondents would consider EVT based on CT only

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee.

We report the updated classification of Inborn Errors of Immunity/Primary Immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee. This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been discovered in the past 2 years since the previous update (published January 2018) or were characterized earlier but have since been confirmed or expanded upon in subsequent studies. The application of next-generation sequencing continues to expedite the rapid identification of novel gene defects, rare or common; broaden the immunological and clinical phenotypes of conditions arising from known gene defects and even known variants; and implement gene-specific therapies. These advances are contributing to greater understanding of the molecular, cellular, and immunological mechanisms of disease, thereby enhancing immunological knowledge while improving the management of patients and their families. This report serves as a valuable resource for the molecular diagnosis of individuals with heritable immunological disorders and also for the scientific dissection of cellular and molecular mechanisms underlying inborn errors of immunity and related human diseases

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification.

Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification into ten tables. This phenotypic classification is user-friendly and serves as a resource for clinicians at the bedside. There are now 430 single-gene IEI underlying phenotypes as diverse as infection, malignancy, allergy, autoimmunity, and autoinflammation. We herein report the 2019 phenotypic classification, including the 65 new conditions. The diagnostic algorithms are based on clinical and laboratory phenotypes for each of the ten broad categories of IEI

The effect of iron deficiency and anaemia on women's health

Iron deficiency and anaemia are global health problems and major causes of morbidity in women. Current definitions of anaemia in women are historic and have been challenged by recent data from observational studies. Menstrual loss, abnormal uterine bleeding and pregnancy put women at risk of developing iron deficiency which can result in severe fatigue, reduced exercise capacity and poor work performance. Iron deficiency and anaemia during pregnancy are associated with adverse maternal and fetal outcomes, including neurocognitive deficits in children born to iron-deficient mothers. Both iron deficiency and anaemia are common in women undergoing surgery but their association with poor outcomes remains uncertain. The enduring burden of iron deficiency and anaemia in women suggests that current strategies for recognition, prevention and treatment are limited in their utility. Improvements in our understanding of iron homeostasis and the development of new iron preparations, which are better absorbed with fewer side-effects, may improve therapeutic effectiveness of oral iron. Intravenous iron is efficacious for correcting anaemia rapidly but high-quality data on patient-centred outcomes and cost-effectiveness are currently lacking. Many recommendations for the treatment of iron deficiency and anaemia in national guidelines are not supported by high-quality evidence. There is a need for robust epidemiological data and well-designed clinical trials. The latter will require collaborative working between researchers and patients to design studies in ways that incorporate patients’ perspectives on the research process and target outcomes that matter to them