Contrasting Pattern of Chronic Inflammatory Bowel Disease in Primary and Autoimmune Sclerosing Cholangitis.

To access publisher's full text version of this article click on the hyperlink at the bottom of the pagePrimary sclerosing cholangitis (PSC) and autoimmune sclerosing cholangitis (AISC) are related, but distinct chronic liver diseases. PSC is associated with a high prevalence of ulcerative colitis while the intestinal inflammation associated with AISC is less well characterised.To assess and contrast aspects of intestinal inflammation in patients with AISC and PSC and compare the clinical features with those of patients with ulcerative colitis and Crohn's disease.23 and 22 patients with AISC and PSC, respectively, underwent review of colonoscopy and biopsy findings, capsule enteroscopy and assessment of clinical and inflammatory (faecal calprotectin) disease activity, which was compared with that of patients with ulcerative colitis and Crohn's disease (n = 55 each).Five and 6 patients with AISC and PSC, respectively, had normal colonoscopy and faecal calprotectin levels of 34.4 ± 8.3 and 39.7 ± 8.4 μg/g, respectively (normal 0.05) between patients with intestinal inflammation in AISC (588 ± 549 μg/g), PSC (421 ± 351 μg/g), ulcerative colitis (501 ± 656 μg/g) or Crohn's disease (476 ± 571 μg/g). Capsule enteroscopy showed that 7 of 18 (39%) (p < 0.03) of those with AISC had small bowel mucosal breaks whereas no patient with PSC had these findings.Collectively these findings lend support to the suggestion that the chronic inflammatory bowel disease associated with PSC and in particular AISC may represent a distinct nosologic entity different from classic ulcerative colitis and Crohn's disease

A journey to ‘tame a small metazoan organism’, ‡ seen through the artistic eyes of C. elegans researchers

In the following pages, we share a collection of photos, drawings, and mixed-media creations, most of them especially made for this JoN issue, manifesting C. elegans researchers’ affection for their model organism and the founders of the field. This is a celebration of our community’s growth, flourish, spread, and bright future. Descriptions provided by the contributors, edited for space.Fil: Gourgou, Eleni. University of Michigan; Estados UnidosFil: Willis, Alexandra R.. University of Toronto; CanadáFil: Giunti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Charlesworth, Amanda G.. University of Toronto; CanadáFil: Hernandez Lima, Mirella. University of Michigan; Estados UnidosFil: Glater, Elizabeth. Pomona College; Estados UnidosFil: Soo, Sonja. McGill University; CanadáFil: Pereira, Bianca. Wayne State University (wayne State University);Fil: Akbas, Kubra. New Jersey Institute of Technology; Estados UnidosFil: Deb, Anushka. Tata Institute of Fundamental Research; IndiaFil: Kamak, Madhushree. Tata Institute of Fundamental Research; IndiaFil: Moyle, Mark W.. University of Yale; Estados UnidosFil: Traa, Annika. McGill University; CanadáFil: Singhvi, Aakanksha. Fred Hutchinson Cancer Research Center; Estados UnidosFil: Sural, Surojit. University of Michigan; Estados UnidosFil: Ji, Eugene J.. University of California at San Diego; Estados Unido