12 research outputs found
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic stress contributes to the etiology of type II diabetes, causing the dedifferentiation of pancreatic beta cells to a cell type reminiscent of endocrine progenitors. Lack of methods to easily model this process in vitro, however, have hindered progress into the identification of key downstream targets and potential inhibitors. We therefore aimed to establish such an in vitro cellular dedifferentiation model and apply it to identify novel agents involved in the maintenance of beta-cell identity
Potential of equestrian tourism in Hungary, popularity of Hortobágy
Szakdolgozatom tĂ©mája a magyarországi lovas turizmus, a jelen állapot Ă©rtĂ©kelĂ©se illetve a lehetsĂ©ges fejlĹ‘dĂ©si irányok ismertetĂ©se. Az ágazaton belĂĽl Hortobágyot helyeztem fĂłkuszpontba. Ennek oka az elmĂşlt Ă©vekben tapasztalt dinamikus fejlĹ‘dĂ©s, illetve hazánk lovas világában elfoglalt rendkĂvĂĽl fontos helye.BSc/BATurizmus-vendĂ©glátásK