The VISTA spacecraft: Advantages of ICF (Inertial Confinement Fusion) for interplanetary fusions propulsion applications

Inertial Confinement Fusion (ICF) is an attractive engine power source for interplanetary manned spacecraft, especially for near-term missions requiring minimum flight duration, because ICF has inherent high power-to-mass ratios and high specific impulses. We have developed a new vehicle concept called VISTA that uses ICF and is capable of round-trip manned missions to Mars in 100 days using A.D. 2020 technology. We describe VISTA's engine operation, discuss associated plasma issues, and describe the advantages of DT fuel for near-term applications. Although ICF is potentially superior to non-fusion technologies for near-term interplanetary transport, the performance capabilities of VISTA cannot be meaningfully compared with those of magnetic-fusion systems because of the lack of a comparable study of the magnetic-fusion systems. We urge that such a study be conducted

Investigations into the potential effects of pedoturbation on luminescence dating

Much effort has been focussed on understanding the luminescence properties of natural minerals to achieve a reliable, accurate and precise dating technique. However, some field related aspects, such as the influence or effect of post-depositional disturbance on luminescence dates, are as yet underexplored. In the case of pedoturbation, depending on its intensity, the rate of sedimentation and unit thicknesses, potentially the whole sedimentary record at a site can be affected. This may lead to distorted OSL chronologies and erroneous sediment burial ages. Pedoturbation can result in sediment mixing and/or exhumation that affect luminescence both at the bulk and single grain level. Effects of these two principle processes on luminescence ages are examined using standard multigrain and single grain protocols. High resolution sampling of surface gopher mounds was used to determine the efficiency of bio-exhumation in resetting luminescence signal. Results show this is an inefficient mechanism for onsite sediment bleaching. The effects on luminescence signal of bio-mixing were explored by comparing a sample collected from within a krotovina (infilled burrow) to an adjacent undisturbed sample. Results show the difficulties in identifying pedoturbated samples at the single aliquot level and the possible inaccuracies in using the lowest palaeodose values to calculate OSL ages. Where pedoturbation of samples is suspected, use of probability plots of palaeodoses data is recommended. From these plots it is proposed that only data falling within a normal distribution centred on the peak probability be used to calculated OSL ages and to mitigate problems arising from pedoturbation

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical execution of the study in Scotland. We thank Sharon Eastwood, Parexel, for assistance in preparing initial drafts of the manuscript. We acknowledge constructive comments provided by Professors G. Wilcock and S. Gauthier on drafts of the article. CMW, CRH, and JMDS are officers of, and hold beneficial interests in, TauRx Therapeutics. RTS, PB, KK, and DJW are paid consultants to TauRx Therapeutics. The study was financed entirely by TauRx TherapeuticsPeer reviewedPublisher PD

The effect of seed moisture content and hot water treatment on carrot seed viability and Alternaria radicina control

Hot water treatment of seeds to control seedborne pathogens is an important tool for organic seed production. Reducing seed moisture content may have the potential to increase carrot (Daucus carota L. var. sativus D.C.) seed tolerance to treatment. Two hot water seed treatment experiments were conducted

The effect of seed moisture content and the duration and temperature of hot water treatment on carrot seed viability and the control of Alternaria Radicina

Hot water treatment of seeds to control seedborne pathogens is an important tool for organic seed production. Reducing seed moisture content may have the potential to increase carrot (Daucus carota L. var. sativus D.C.) seed tolerance to treatment. Two hot water seed treatment experiments were conducted. The first studied the effect of seed moisture content (SMC), treatment temperature and treatment duration on germination. Maximum safe treatment temperature and durations were established at 50°C and 30-40 min. Germination decreased slightly from 68% at 5% SMC to 63% at 20% SMC (LSD 1.2) for all durations. The second experiment studied the effect of initial SMC and treatment durations on infestation of seed by Alternaria radicina and seed germination. Treatment at 50°C for 30 min for all SMC compared to the control resulted in a decrease in A. radicina infestation from 69.2 to 1.7%. Reducing SMC from 20 to 5% for all durations resulted in a small decrease in infestation from 25% to 18% (LSD 1.5). Reducing SMC to 5% prior to hot water treatment may be a commercially viable means of minimising reductions in seed viability and decreasing fungal infestation levels

Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL) : Study design and baseline data

Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. Methods: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin 700 μg/L and/or TSAT ≥40%) or a reactive, low-dose IV iron arm (iron sucrose administered if ferritin <200 μg/L or TSAT < 20%). We hypothesized that proactive, high-dose IV iron would be noninferior to reactive, low-dose IV iron for the primary outcome of first occurrence of nonfatal myocardial infarction (MI), nonfatal stroke, hospitalization for heart failure or death from any cause. If noninferiority is confirmed with a noninferiority limit of 1.25 for the hazard ratio of the proactive strategy relative to the reactive strategy, a test for superiority will be carried out. Secondary outcomes include infection-related endpoints, ESA dose requirements, and quality-of-life measures. As an event-driven trial, the study will continue until at least 631 primary outcome events have accrued, but the expected duration of follow-up is 2-4 years. Results: Of the 2,589 patients screened across 50 UK sites, 2,141 (83%) were randomized. At baseline, 65.3% were male, the median age was 65 years, and 79% were white. According to eligibility criteria, all patients were on ESA at screening. Prior stroke and MI were present in 8 and 9% of the cohort, respectively, and 44% of patients had diabetes at baseline. Baseline data for the randomized cohort were generally concordant with recent data from the UK Renal Registry. Conclusions: PIVOTAL will provide important information about the optimum dosing of IV iron in HD patients representative of usual clinical practice. Trial Registration: EudraCT number: 2013-002267-25.Peer reviewedFinal Published versio

DNA replication initiation in Bacillus subtilis: Structural and functional characterization of the essential DnaA-DnaD interaction

© 2018 The Author(s). The homotetrameric DnaD protein is essential in low G+C content gram positive bacteria and is involved in replication initiation at oriC and re-start of collapsed replication forks. It interacts with the ubiquitously conserved bacterial master replication initiation protein DnaA at the oriC but structural and functional details of this interaction are lacking, thus contributing to our incomplete understanding of the molecular details that underpin replication initiation in bacteria. DnaD comprises N-terminal (DDBH1) and C-terminal (DDBH2) domains, with contradicting bacterial two-hybrid and yeast two-hybrid studies suggesting that either the former or the latter interact with DnaA, respectively. Using Nuclear Magnetic Resonance (NMR) we showed that both DDBH1 and DDBH2 interact with the N-terminal domain I of DnaA and studied the DDBH2 interaction in structural detail. We revealed two families of conformations for the DDBH2-DnaA domain I complex and showed that the DnaA-interaction patch of DnaD is distinct from the DNA-interaction patch, suggesting that DnaD can bind simultaneously DNA and DnaA. Using sensitive single-molecule FRET techniques we revealed that DnaD remodels DnaA-DNA filaments consistent with stretching and/or untwisting. Furthermore, the DNA binding activity of DnaD is redundant for this filament remodelling. This in turn suggests that DnaA and DnaD are working collaboratively in the oriC to locally melt the DNA duplex during replication initiation