Validity of state cancer registry treatment information for adolescent and young adult women

Background: Population-based cancer registries collect information on first course of treatment that may be utilized in research on cancer care quality, yet few studies have investigated the validity of this information. We examined the accuracy and completeness of registry-based treatment information in a cohort of adolescent and young adult women. Methods: Women diagnosed with breast cancer, lymphoma, thyroid cancer, cervical/uterine cancer or ovarian cancer at ages 15–39 during 2003–2014 were identified using data from the North Carolina Central Cancer Registry (CCR) (N = 2342). CCR data were linked to Medicaid and private insurance claims data, and claims were reviewed for the 12 months following diagnosis to identify cancer treatments received. Using claims data as the gold standard, we calculated the sensitivity and positive predictive value (PPV) of CCR data for receipt of chemotherapy, radiation and hormone therapy. We also compared dates of treatment initiation between the two data sources. Results: For all cancer types combined, the sensitivity of the CCR data was high for chemotherapy (86%) and moderate for radiation (74%). PPVs were 82% and 83% for chemotherapy and radiation, respectively. Both the sensitivity (67%) and PPV (70%) were lower for hormone therapy for breast cancer. For all three treatment types, dates of initiation in the registry and the claims differed by ≤30 days for most women. Conclusions: In this cohort of young women, population-based cancer registry data on chemotherapy receipt was reasonably accurate and complete in comparison with insurance claims. Radiation and hormone therapy appeared to be less complete

CP violation in Bd,s→l+l−B_{d,s} \to l^+l^- in the model III 2HDM

We have calculated the Wilson coefficients $C_{10}, C_{Q_i}$ (i=1,2) in the $\bar{MS}$ renormalization scheme in the model III 2HDM. Using the obtained Wilson coefficients, we have analyzed the CP violation in decays $B^0_q\to l^+l^-$ (q=d,s) in the model. The CP asymmetry, $A_{CP}$, depends on the parameters of models and $A_{CP}$ in $B_d\to l^+l^-$ can be as large as 40% and 35% for $l=\tau$ and $l=\mu$ respectively. It can reach 4% for $B^0_s$ decays. Because in SM CP violation is smaller than or equal to O($10^{-3}$) which is unobservably small, an observation of CP asymmetry in the decays $B^0_q \to l^+l^- (q=d,s)$ would unambiguously signal the existence of new physics.Comment: revtex4, 16 pages, 7 figure

Top Quark Decays into Heavy Quark Mesons

For top quark decays into heavy quark mesons $\Upsilon$ and $\bar{B}_c^*$ , a complete calculation to the leading order both in QCD coupling constant $\alpha_s$ and in $v$, the typical velocity of the heavy quarks inside the mesons, is performed. Relatons between the top quark mass and the decay branching ratios are studied. Comparion with the results which are obtained by using the quark frangmentation functions is also discussed. The branching ratios are consistent (within a factor of $2\sim 3$) with that obtained using fragmentation functions at $m_t\sim 150$ GeV.Comment: 15 pages in LaTex form, 4 figures include

Pregnancy attempts among adolescent and young adult cancer survivors

Objective: To examine whether demographic and cancer-related characteristics and factors such as fertility discussion with a medical provider and fertility preservation use are associated with attempting pregnancy after adolescent and young adult cancer. Design: Cross-sectional online survey. Setting: Not applicable. Patient(s): Women with lymphoma, breast cancer, thyroid cancer, or gynecologic cancer diagnosed at 15–39 years from 2004 to 2016 were identified from the North Carolina Cancer Registry and the Kaiser Permanente Northern and Southern California health care systems and responded to an online survey addressing survivorship concerns, including fertility and reproductive outcomes. Exposures: Demographic characteristics, cancer characteristics, fertility discussion with a medical provider or fertility specialist between cancer diagnosis and starting cancer treatment, use of fertility preservation strategies (freezing embryos or oocytes) after cancer diagnosis. Main Outcome Measure(s): Pregnancy attempt after cancer diagnosis, defined by either a pregnancy or 12 months of trying to become pregnant without pregnancy. Result(s): Among 801 participants who had not reached their desired family size at diagnosis, 77% had a fertility discussion with any medical provider between cancer diagnosis and treatment initiation, and 8% used fertility preservation after cancer diagnosis. At survey (median =7 years after diagnosis; interquartile range, 4–10), 32% had attempted pregnancy. Neither fertility discussion with any medical provider nor fertility counseling with a fertility specialist was significantly associated with pregnancy attempts. However, the use of fertility preservation was significantly associated with attempting pregnancy (prevalence ratios = 1.74; 95% confidence interval: 1.31–2.32). Other characteristics positively associated with pregnancy attempts included younger age at diagnosis, longer time since diagnosis, having a partner (at diagnosis or at survey), and having a history of infertility before cancer diagnosis. Conclusion(s): Use of fertility preservation strategies was uncommon in our cohort but was associated with attempting pregnancy after cancer. Ensuring access to fertility preservation methods may help adolescent and young adult cancer survivors to plan and initiate future fertility

Material and psychological financial hardship related to employment disruption among female adolescent and young adult cancer survivors

Background: The importance of addressing adverse financial effects of cancer among adolescents and young adults (AYAs) is paramount as survival improves. In the current study, the authors examined whether cancer-related employment disruption was associated with financial hardship among female AYA cancer survivors in North Carolina and California. Methods: AYA cancer survivors identified through the North Carolina Central Cancer Registry and the Kaiser Permanente Northern/Southern California tumor registries responded to an online survey. Disrupted employment was defined as reducing hours, taking temporary leave, or stopping work completely because of cancer. Financial hardship was defined as material conditions or psychological distress related to cancer. Descriptive statistics and chi-square tests were used to characterize the invited sample and survey respondents. Marginal structural binomial regression models were used to estimate prevalence differences (PDs) and 95% confidence intervals (95% CIs). Results: Among 1328 women employed at the time of their diagnosis, women were a median age of 34 years at the time of diagnosis and 7 years from diagnosis at the time of the survey and approximately 32% experienced employment disruption. A substantial percentage reported financial hardship related to material conditions (27%) or psychological distress (50%). In adjusted analyses, women with disrupted employment had a 17% higher burden of material conditions (95% CI, 10%-23%) and an 8% higher burden of psychological distress (95% CI, 1%-16%) compared with those without disruption. Conclusions: Financial hardship related to employment disruption among female AYA cancer survivors can be substantial. Interventions to promote job maintenance and transition back to the workforce after treatment, as well as improved workplace accommodations and benefits, present an opportunity to improve cancer survivorship

Development of an eight-band theory for quantum-dot heterostructures

We derive a nonsymmetrized 8-band effective-mass Hamiltonian for quantum-dot heterostructures (QDHs) in Burt's envelope-function representation. The 8x8 radial Hamiltonian and the boundary conditions for the Schroedinger equation are obtained for spherical QDHs. Boundary conditions for symmetrized and nonsymmetrized radial Hamiltonians are compared with each other and with connection rules that are commonly used to match the wave functions found from the bulk kp Hamiltonians of two adjacent materials. Electron and hole energy spectra in three spherical QDHs: HgS/CdS, InAs/GaAs, and GaAs/AlAs are calculated as a function of the quantum dot radius within the approximate symmetrized and exact nonsymmetrized 8x8 models. The parameters of dissymmetry are shown to influence the energy levels and the wave functions of an electron and a hole and, consequently, the energies of both intraband and interband transitions.Comment: 36 pages, 10 figures, E-mail addresses: [email protected], [email protected]

Fertility Preservation and Financial Hardship among Adolescent and Young Adult Women with Cancer

Background: Financial hardship among adolescents and young adults (AYA) with cancer who receive gonadotoxic treatments may be exacerbated by the use of fertility services. This study examined whether AYA women with cancer who used fertility preservation had increased financial hardship. Methods: AYA women with cancer in North Carolina and California completed a survey in 2018–2019. Cancer-related financial hardship was compared between women who cryopreserved oocytes or embryos for fertility preservation after cancer diagnosis (n ¼ 65) and women who received gonadotoxic treatment and reported discussing fertility with their provider, but did not use fertility preservation (n ¼ 491). Multivariable log-binomial regression was used to estimate prevalence ratios and 95% confidence intervals (CI). Results: Women were a median age of 33 years at diagnosis and 7 years from diagnosis at the time of survey. Women who used fertility preservation were primarily ages 25 to 34 years at diagnosis (65%), non-Hispanic White (72%), and had at least a Bachelor’s degree (85%). In adjusted analysis, use of fertility preservation was associated with 1.50 times the prevalence of material financial hardship (95% CI: 1.08–2.09). The magnitude of hardship was also substantially higher among women who used fertility preservation: 12% reported debt of ≥$25,000 versus 5% in the referent group. Conclusions: This study provides new evidence that cryopreserving oocytes or embryos after cancer diagnosis for future family building is associated with increased financial vulnerability. Impact: More legislation that mandates insurance coverage to mitigate hardships stemming from iatrogenic infertility could improve access to fertility preservation for young women with cancer

Resolving Fermi, PAMELA and ATIC anomalies in split supersymmetry without R-parity

A long-lived decaying dark matter as a resolution to Fermi, PAMELA and ATIC anomalies is investigated in the framework of split supersymmetry (SUSY) without R-parity, where the neutralino is regarded as the dark matter and the extreme fine-tuned couplings for the long-lived neutralino are naturally evaded in the usual approach.Comment: 14 pages, 6 figures. Erroneous results concerning the cascade processes removed. Main results unchange

Fragmentation Function and Hadronic Production of the Heavy Supersymmetric Hadrons

The light top-squark \sto may be the lightest squark and its lifetime may be `long enough' in a kind of SUSY models which have not been ruled out yet experimentally, so colorless `supersymmetric hadrons (superhadrons)' (\sto \bar{q}) ($q$ is a quark except $t$-quark) may be formed as long as the light top-squark \sto can be produced. Fragmentation function of \sto to heavy `supersymmetric hadrons (superhadrons)' (\sto \bar{Q}) ($\bar{Q}=\bar{c}$ or $\bar{b}$) and the hadronic production of the superhadrons are investigated quantitatively. The fragmentation function is calculated precisely. Due to the difference in spin of the SUSY component, the asymptotic behavior of the fragmentation function is different from those of the existent ones. The fragmentation function is also applied to compute the production of heavy superhadrons at hadronic colliders Tevatron and LHC under the so-called fragmentation approach. The resultant cross-section for the heavy superhadrons is too small to observe at Tevatron, but great enough at LHC, even when all the relevant parameters in the SUSY models are taken within the favored region for the heavy superhadrons. The production of `light superhadrons' (\sto \bar{q}) ($q=u, d, s$) is also roughly estimated. It is pointed out that the production cross-sections of the light superhadrons (\sto \bar{q}) may be much greater than those of the heavy superhadrons, so that even at Tevatron the light superhadrons may be produced in great quantities.Comment: 20 pages, 9 figure

Statin use and risk of multiple myeloma: An analysis from the cancer research network

Animal and human data suggest statins may be protective against developing multiple myeloma; however, findings may be biased by the interrelationship with lipid levels. We investigated the association between statin use and risk of multiple myeloma in a large US population, with an emphasis on accounting for this potential bias. We conducted a case-control study nested within 6 US integrated healthcare systems participating in the National Cancer Institute-funded Cancer Research Network. Adults aged ≥40 years who were diagnosed with multiple myeloma from 1998–2008 were identified through cancer registries (N = 2,532). For each case, five controls were matched on age, sex, health plan, and membership duration prior to diagnosis/index date. Statin prescriptions were ascertained from electronic pharmacy records. To address potential biases related to lipid levels and medication prescribing practices, multivariable marginal structural models were used to model statin use (≥6 cumulative months) and risk of multiple myeloma, with examination of multiple latency periods. Statin use 48–72 months prior to diagnosis/index date was associated with a suggestive 20–28% reduced risk of developing multiple myeloma, compared to non-users. Recent initiation of statins was not associated with myeloma risk (risk ratio range 0.90–0.99 with 0–36 months latency). Older patients had more consistent protective associations across all latency periods (risk ratio range 0.67–0.87). Our results suggest that the association between statin use and multiple myeloma risk may vary by exposure window and age. Future research is warranted to investigate the timing of statin use in relation to myeloma diagnosis