Nickel-Catalyzed Arylative Carboxylation of Alkynes with Arylmagnesium Reagents and Carbon Dioxide Leading to Trisubstituted Acrylic Acids

Nickel-catalyzed arylcarboxylation of alkynes with arylmagnesium reagents and carbon dioxide (CO₂, 1 atm) was realized in one pot. Various trisubstituted acrylic acids within an aryl group at the β-position have been prepared efficiently with good regioselectivity under mild conditions. The resulting products could be further transformed to benzoannelated cycles retaining CO₂ as a one-carbon synthon

Copper-Promoted Tandem Reaction of Azobenzenes with Allyl Bromides via NN Bond Cleavage for the Regioselective Synthesis of Quinolines

A copper-promoted tandem reaction of a variety of azobenzenes and allyl bromides via NN bond cleavage to regioselectively construct quinoline derivatives has been developed. The azobenzenes act as not only construction units but also an oxidant for quinoline formation

MeOTf-Induced Carboannulation of Isothiocyanates and Aryl Alkynes with CS Bond Cleavage: Access to Indenones

MeOTf-induced carboannulation of alkyl isothiocyanates and aryl alkynes for the synthesis of indenones in good yields under metal-free conditions with CS bond cleavage is described. The thioalkoxy group at the 3-position of the indenone can also be converted into other functional groups, such as phenyl, methylsulfonyl, amino, and ethoxy groups

Assembly of 3-Substituted Isocoumarins via a CuI-Catalyzed Domino Coupling/Addition/Deacylation Process

An efficient strategy for the synthesis of a variety of 3-substituted isocoumarins has been developed. The reaction proceeded from <i>o</i>-halobenzoic acids and 1,3-diketones via a copper­(I)-catalyzed domino reaction in DMF under the action of K₃PO₄ at 90–120 °C without a ligand to afford the corresponding 3-substituted isocoumarin derivatives in good to excellent yields. <i>o</i>-Halobenzoic acids could be <i>o</i>-iodobenzoic acid, <i>o</i>-bromobenzoic acid, and <i>o</i>-chlorobenzoic acid derivatives. 1,3-Diketones could be alkyl- and aryl-substituted 1,3-diketones

Chemoselective Phosphination of Titanacyclobutene: A Convenient Method for Synthesis of Allylphosphine Derivatives

Titanacyclobutenes reacted with chlorophosphine to afford titanoallylphosphines with high chemoselectivity, and the resulting titanoallylphosphine could be converted into functionalized allylphosphine sulfides via reactions with various electrophiles

Cp₂TiCl₂‑Catalyzed Regioselective Hydrocarboxylation of Alkenes with CO₂

Cp₂TiCl₂-catalyzed regioselective hydrocarboxylation of alkenes with CO₂ to give carboxylic acids in high yields has been developed in the presence of ^<i>i</i>PrMgCl. The reaction proceeds with a wide range of alkenes under mild conditions. Styrene and its derivatives can transform to α-aryl carboxylic acids, and aliphatic alkenes can transform to form alkanoic acids

Copper-Mediated Reaction of Zirconacyclopentadienes with Azides: A One-Pot Three-Component Synthesis of Multiply Substituted Pyrroles from One Azide and Two Alkynes

A general method for the synthesis of multiply substituted pyrroles through zirconocene-mediated coupling of two alkynes and an azide in the presence of CuCl has been achieved

Concise Approach to Benzisothiazol-3(2<i>H</i>)-one via Copper-Catalyzed Tandem Reaction of <i>o</i>-Bromobenzamide and Potassium Thiocyanate in Water

A concise approach to various benzisothiazol-3­(2<i>H</i>)-one derivatives has been developed by copper-catalyzed the reaction of <i>o</i>-bromobenzamide derivatives with potassium thiocyanate (KSCN) in water. The reaction proceeds via a tandem reaction with S–C bond and S–N bond formation

Alkyltriflate-Triggered Annulation of Aryl­isothio­cyanates and Alkynes Leading to Multiply Substituted Quinolines through Domino Electrophilic Activation

The reaction of arylisothiocyanate, alkyltriflate, and alkynes leads to variously substituted quinolines in high yields. The reaction undergoes alkyltriflate-triggered domino electrophilic activation and avoids the use of a transition-metal catalyst. A variety of functional groups are tolerated in the quinoline ring

Rh(III)-Catalyzed Cascade Oxidative Olefination/Cyclization of Picolinamides and Alkenes via C–H Activation

Rh­(III)-catalyzed cascade oxidative alkenylation/cyclization of picolinamides and alkenes to furnish pyrido pyrrolone derivatives is described, in which three C–H bonds and one N–H bond broke, while one C–C bond and one C–N bond formed. The reaction proceeded with high yield and high regioselectivity and stereoselectivity. Moreover, copper acetate can also be used in catalytic amounts with O₂ serving as the terminal oxidant