Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached ∼24 and ∼15  dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm

Nonreciprocal singularities dominated by the dissipative photon-magnon coupling in non-Hermitian systems

We investigated the magnon-photon coupling in an open cavity magnonic system, which leads to two different nonreciprocal singularities dominated by the dissipative coupling. One type of singularity is the exceptional point, which is just on the exceptional surface in parameter space. The other type of singularity is the bound state in the continuum discovered in the level-attraction-like coupling, which is above the exceptional surface. In experiment, we realized the two different singularities with nonreciprocity and selectivity in an open cavity magnonic system with suitable dissipation rating. Our results can be understood well with the pseudo-Hermitian theory of magnon-polariton system

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached ∼24 and ∼15  dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm

Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study

Objectives: Knee synovitis is a highly prevalent and potentially curable condition for knee pain; however, its pathogenesis remains unclear. We sought to assess the associations of the gut fungal microbiota and the fungi–bacteria correlation network with knee synovitis. Methods: Participants were derived from a community-based cross-sectional study. We performed an ultrasound examination of both knees. A knee was defined as having synovitis if its synovium was ≥4 mm and/or Power Doppler (PD) signal was within the knee synovium area (PD synovitis). We collected faecal specimens from each participant and assessed gut fungal and bacterial microbiota using internal transcribed spacer 2 and shotgun metagenomic sequencing. We examined the relation of α-diversity, β-diversity, the relative abundance of taxa and the interkingdom correlations to knee synovitis. Results: Among 977 participants (mean age: 63.2 years; women: 58.8%), 191 (19.5%) had knee synovitis. β-diversity of the gut fungal microbiota, but not α-diversity, was significantly associated with prevalent knee synovitis. The fungal genus Schizophyllum was inversely correlated with the prevalence and activity (ie, control, synovitis without PD signal and PD synovitis) of knee synovitis. Compared with those without synovitis, the fungi–bacteria correlation network in patients with knee synovitis was smaller (nodes: 93 vs 153; edges: 107 vs 244), and the average number of neighbours was fewer (2.3 vs 3.2). Conclusion: Alterations of gut fungal microbiota and the fungi–bacteria correlation network are associated with knee synovitis. These novel findings may help understand the mechanisms of the gut-joint axis in knee synovitis and suggest potential targets for future treatment

Study on the Heat Transfer Characteristics of an Ambient Air Vaporizer with Multi-Component Fluids

China’s LNG import volume in 2021 reached 121.356 million tons, which makes China the largest importer in the world. The ambient air vaporizer (AAV) for LNG vaporization is an ideal selection for minimizing the average monetary value of terminals and maximizing operating efficiency. However, the heat and mass transfer performance of real multi-component LNG is not the same as that of the pure component in AAV; what is more, deep cryogenic and multi-component characteristics of LNG could lead to the deterioration of heat-transfer performance, which may cause catastrophic consequences. Thus, this difficulty should be concerning and solved in its operation. Based on the law of conservation of energy and mass, a heat and mass transfer model was established that can calculate the coupled heat transfer from the LNG to the air-side of the AAV along its own length. Empirical correlations are proposed to predict some basic properties of the frost layer at the outside of the tube, where the internal fluid is seen as a pure component and a multi-component. The numerical results show that the root–mean–square error (RMS) of the frost thickness is 0.749 mm, and the RMS of the outlet fluid temperature is 2.06 K and 2.21 K in summer and winter, respectively. That is in good agreement with the experimental data in the previous literature. The results show that the length of the finned tube in the AAV affected by pure CH4 was increased by 42.5%; therefore, we recommend shortening the finned tube on the basis of safety to save costs. Compared to the pure components reference experiments, when the CH4 content of multi-component in five regions was 78.48–96.91%, it is found that the different varieties of thermodynamic dryness degree x within the two types of components is the key point for the distinct mechanisms of the heat transfer characteristics of the AAV. Additionally, compared to changing the design pressure and flow rate, it is found that varying the flow rate has a much greater impact on the heat and mass transfer performance of the AAV than changing its pressure. The calculation of the coupled heat and mass transfer of the AAV can provide a theoretical basis for subsequent engineering designs