MotionTrack: Learning Motion Predictor for Multiple Object Tracking

Significant progress has been achieved in multi-object tracking (MOT) through the evolution of detection and re-identification (ReID) techniques. Despite these advancements, accurately tracking objects in scenarios with homogeneous appearance and heterogeneous motion remains a challenge. This challenge arises from two main factors: the insufficient discriminability of ReID features and the predominant utilization of linear motion models in MOT. In this context, we introduce a novel motion-based tracker, MotionTrack, centered around a learnable motion predictor that relies solely on object trajectory information. This predictor comprehensively integrates two levels of granularity in motion features to enhance the modeling of temporal dynamics and facilitate precise future motion prediction for individual objects. Specifically, the proposed approach adopts a self-attention mechanism to capture token-level information and a Dynamic MLP layer to model channel-level features. MotionTrack is a simple, online tracking approach. Our experimental results demonstrate that MotionTrack yields state-of-the-art performance on datasets such as Dancetrack and SportsMOT, characterized by highly complex object motion

RETRACTED: Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer

LncRNAs play important roles in bladder cancer. However, only a few studies report on the correlation between lncRNAs expression and autophagy in bladder cancer. This study aimed to explore the effect of lncRNA on autophagy in bladder cancer. The findings showed high expression of SNHG1 in the bladder cancer cells and tumor tissues. The high expression of SNHG1 was positively correlated with bladder cancer cell invasion, proliferation, and autophagy. This finding implies that SNHG1 promotes bladder cancer cell invasion and proliferation via autophagy. Further analysis of the mechanism of action of SNHG1 showed that it functions as a sponge of miRNA-493 in bladder cancer. miRNA-493 binds on the 3’ -UTR of ATG14 mRNA thus affecting ATG14 protein expression, which is implicated in autophagy. These findings are supported by previous preclinical studies using multiple Bca cell lines and TCGA, which demonstrate that SNHG1 plays an oncogenic role by acting as a sponge of miR-493-5p or as its ceRNA. Upregulation of SNHG1 promotes proliferation, invasion, and autophagy of bladder cancer cells through the miR-493-5p/ATG14/autophagy pathway. Therefore, SNHG1 may act as a potential therapeutic target for the treatment of bladder cancer

Improving Multiple Pedestrian Tracking in Crowded Scenes with Hierarchical Association

Recently, advances in detection and re-identification techniques have significantly boosted tracking-by-detection-based multi-pedestrian tracking (MPT) methods and made MPT a great success in most easy scenes. Several very recent works point out that the two-step scheme of first detection and then tracking is problematic and propose using the bounding box regression head of an object detector to realize data association. In this tracking-by-regression paradigm, the regressor directly predicts each pedestrian’s location in the current frame according to its previous position. However, when the scene is crowded and pedestrians are close to each other, the small and partially occluded targets are easily missed. In this paper, we follow this pattern and design a hierarchical association strategy to obtain better performance in crowded scenes. To be specific, at the first association, the regressor is used to estimate the positions of obvious pedestrians. At the second association, we employ a history-aware mask to filter out the already occupied regions implicitly and look carefully at the remaining regions to find out the ignored pedestrians during the first association. We integrate the hierarchical association in a learning framework and directly infer the occluded and small pedestrians in an end-to-end way. We conduct extensive pedestrian tracking experiments on three public pedestrian tracking benchmarks from less crowded to crowded scenes, demonstrating the proposed strategy’s effectiveness in crowded scenes

Resilience Evaluation and Enhancement Strategy of Distribution Network Considering Impact of Seismic Attack on Transportation Networks

Serious earthquake disasters not only cause power outages in distribution network, but also destroy transportation networks, which hinders the transportation of resources for restoration of distribution network and slows down the restoration. This paper proposes an improved resilience evaluation method and a resilience enhancement strategy of distribution network considering the effects of seismic attack on transportation networks. First, a seismic attack model is established to describe the relation between earthquake disasters and failure probability of transportation-distribution networks based on peak ground acceleration. The impact of earthquake disasters on transportation-distribution networks is quantified, and the failure scenarios are generated. Then, a resilience evaluation index is proposed by introducing the waiting time for road repair of emergency repair teams. Afterwards, a bi-level optimization model for distribution network restoration considering the fault line repair, the road repair, and the emergency resource scheduling is established and solved. The upper layer aims at the minimum power loss load, while the lower layer takes the minimum waiting time of the repair team as the goal. Finally, case studies on a coupling example of a 12-node transportation network and an IEEE 33-node distribution network verify the feasibility of the improved resilience index and the effectiveness of the proposed method. The results show that the resilience index considering seismic attack on transportation networks is accurate, and the restoration strategy can effectively enhance the resilience of distribution network in earthquake disasters

Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis

Purpose. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disorder. Although ferroptosis is closely associated with inflammation, oxidative stress, and neuropathic pain, its role in CP/CPPS has not yet been elucidated. Therefore, we sought to explore the role and mechanism of ferroptosis in the prostatitis development. Methods. The experimental autoimmune prostatitis (EAP) was established through intradermal immunization of prostate extract. Iron chelator deferoxamine (DFO) and free radical scavenger edaravone (EDA) were applied to evaluate the effects of ferroptosis inhibition on oxidative stress, ferroptosis, inflammation, fibrosis, and mast cell activation in the context of CP/CPPS. Results. Increased generation of lipid peroxidation products (ROS and MDA) and decreased activities of antioxidant enzymes (SOD and CAT) suggested an aberrant oxidative stress status in EAP model. Elevated iron concentration was observed in the EAP model. Meanwhile, we discovered significant biological performances associated with ferroptosis in CP/CPPS, including the downregulation of the system Xc-/GPX4 axis and the upregulation of the ACSL4/LPCAT3 axis. EAP rats performed serious leukocyte infiltration, advanced inflammatory grade, and abnormal expression of inflammatory mediators. Abundant collagen deposition, enhanced RhoA, ROCK1, and α-SMA protein levels indicated that EAP rats were prone to suffer from stromal fibrosis compared with control group. An elevated number of degranulated mast cells and corresponding marker TPSB2 represented that mast cell-sensitized pain was amplified in the EAP model. Furthermore, reduction of NRF2/HO-1 indicated a vulnerability of EAP towards ferroptosis response. However, application of DFO and EDA had partially reversed the adverse influences mentioned above. Conclusion. We first demonstrated that ferroptosis might be a crucial factor of chronic prostatitis progression. Inhibition of ferroptosis using DFO and EDA represented a promising approach for treating prostatitis by ameliorating inflammation, fibrosis, and mast cell activation

3D Physical Simulation Experiment of Edge Water Reservoir by Polymer/Surfactant Binary Flooding

To investigate the enhanced oil recovery (EOR) technology by chemical flooding in an edge water reservoir, a 3D physical simulation experimental device for the edge water reservoir was developed, and polymer/surfactant binary flooding experiments were carried out under different edge water energies. In addition, the effect and mechanism of binary flooding on EOR under different edge water energies were comprehensively analyzed. Experimental results show that edge water intrusion considerably affects EOR by binary flooding. The stronger the edge water energy, the worse the effect of EOR by binary flooding. Edge water possibly diluted the concentration of the chemical agent medium that is injected into the reservoir, and the degree of dilution varied in different regions. The dilution region was mainly distributed between the injection wells and edge water. The stronger the edge water energy, the higher the dilution multiple of chemical agent and the greater the recovery loss rate by binary flooding

Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates

Objective. The aim of the present study was to investigate the protective effects and mechanisms of KLK1 on aging-related prostate alterations and search clues about the application of KLK1 to the treatment of human BPH. Methods. Thirty-six rats including 26 male wild-type SD rats and 10 transgenic rats were fed to 3- or 18-month-old and divided into three groups: young WTR (yWTR) as the control (n=16), aged WTR (aWTR) (n=10), and aged TGR (aTGR) (n=10). The prostates of the three groups of rats (10 rats per group) were harvested to evaluate the levels of KLK1 expression, oxidative stress, fibrosis, and involved signaling pathways, such as NO/cGMP, COX-2/PTGIS/cAMP, and TGF-β1/RhoA/ROCK1, via quantitative PCR, Western blot, histological examinations, and ELISA. Moreover, the remaining 6 yWTRs were sacrificed to obtain primary prostate fibroblast and aortic endothelial cells, and a coculture system was built with the cells for the verification of above signaling pathways in vitro. And the direct effects of bradykinin on prostate cells were detected by MTT experiment. Prostate specimens of 47 patients (age from 48 to 92 years) undergoing BPH surgery were collected after approval. Histological examinations and KLK1 IHC were preformed to analyze the relationship between KLK1 expression and age and prostate fibrosis. Results. The human KLK1 gene only existed and was expressed in aTGR. The prostate of young rats expressed more KLK1 than the aged and the expression of KLK1 in prostate decreased with age in humans (r=−0.347, P=0.018). Compared to the aWTR group, the yWTR and aTGR groups showed milder fibrosis, less oxidative stress, upregulated NO/cGMP, and COX-2/PTGIS/cAMP signaling pathways and inhibited TGF-β1/RhoA/ROCK1 signaling pathway. In the coculture system, KLK1 suppressed TGF-β1-mediated fibroblast-to-myofibroblast transdifferentiation via cleaving LMWK to produce the BK which upregulate eNOS expression and NO production in endothelial cells. BK not only slightly stimulated the proliferation ability of prostatic stromal cells but also upregulated iNOS and inhibited TGF-β1 expression in them. Conclusion. KLK1 protects prostate from oxidative stress and fibrosis via amplified NO/cGMP signal in aged rats. The decrease of KLK1 expression with aging is laying the groundwork for the application of KLK1 to the treatment of human BPH. The current experimental data showed that the side effects of KLK1 on the prostate cell were not obvious

Enhancing Online UAV Multi-Object Tracking with Temporal Context and Spatial Topological Relationships

Multi-object tracking in unmanned aerial vehicle (UAV) videos is a critical visual perception task with numerous applications. However, existing multi-object tracking methods, when directly applied to UAV scenarios, face significant challenges in maintaining robust tracking due to factors such as motion blur and small object sizes. Additionally, existing UAV methods tend to underutilize crucial information from the temporal and spatial dimensions. To address these issues, on the one hand, we propose a temporal feature aggregation module (TFAM), which effectively combines temporal contexts to obtain rich feature response maps in dynamic motion scenes to enhance the detection capability of the proposed tracker. On the other hand, we introduce a topology-integrated embedding module (TIEM) that captures the topological relationships between objects and their surrounding environment globally and sparsely, thereby integrating spatial layout information. The proposed TIEM significantly enhances the discriminative power of object embedding features, resulting in more precise data association. By integrating these two carefully designed modules into a one-stage online MOT system, we construct a robust UAV tracker. Compared to the baseline approach, the proposed model demonstrates significant improvements in MOTA on two UAV multi-object tracking benchmarks, namely VisDrone2019 and UAVDT. Specifically, the proposed model achieves a 2.2% improvement in MOTA on the VisDrone2019 benchmark and a 2.5% improvement on the UAVDT benchmark

High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression

Abstract As men age, a growing number develop benign prostatic hyperplasia (BPH). According to previous research, diabetes may be a risk factor. Pyruvate dehydrogenase kinase 4 (PDK4) is closely related to glucose metabolism and plays a role in the onset and progression of numerous illnesses. This study aimed to determine the direct effects of high glucose environment on prostate epithelial cells, in particular by altering PDK4 expression levels. In this investigation, normal prostatic epithelial cells (RWPE-1) and human benign prostatic hyperplasia epithelial cells (BPH-1) were treated with 50 mM glucose to show the alteration of high glucose in prostate cells. PDK4-target siRNA, PDK4-expression plasmid were used to investigate the effects of PDK4. Rosiglitazone (RG), a PPARγ agonist, with the potential to up-regulate PDK4 expression was also used for treating prostate cells. The expression of PDK4 in human prostate samples was also analyzed. The effects of high glucose therapy on BPH-1 and RWPE-1 cells were demonstrated to enhance proliferation, epithelial-mesenchymal transition (EMT), suppress apoptosis, and down-regulate PDK4 expression. Additionally, diabetes-related BPH patients had reduced PDK4 expression. Following the application of PDK4-target siRNA, a comparable outcome was seen. The PDK4-expression plasmid therapy, however, produced the opposite results. RG with the ability to elevate PDK4 expression might be used to treat BPH. Changes in the metabolism of lipids and glucose may be the cause of these consequences. These findings showed that high glucose treatment might facilitate BPH development, and may be related to the down-regulation of PDK4. PDK4 might be a potential therapeutic target of BPH

Study on the Mechanism of Water and Sand Leakage in a Foundation Pit Retaining Structure Based on the Computational Fluid Dynamics–Discrete Element Method

The existence of defects in the enclosure structure is the primary cause of water and sand leakage in foundation pits, as well as being a significant source of danger in pit construction, but current research lacks an in-depth investigation of the generation mechanism and gestation process. In this paper, which comprehensively considers the microscopic particles and macroscopic level, the development mechanism of a water and sand leakage disaster in a foundation pit with a water-rich sand layer was studied using the principle of computational fluid dynamics and discrete element method coupled analysis (CFD–DEM); moreover, based on the anisotropy of the particle force and fluid energy analysis, the deformation of the stratum and ground stress field were analyzed. The results show that the stress field will produce a plugging effect at a certain distance from the defect, and the strata exhibit a dominant displacement tendency in the vertical direction, resulting in the emergence of a gradually concave stress relaxation zone and an elliptical contour in the strata displacement map near the defect. The fluid energy describes the displacement of the sand layer very well, and it is separated into the sand layer’s centralized loss region and the major loss area based on the high and low levels of the fluid energy class. The impact of fluid at the defect reaches the maximum kinetic energy, which penetrates the structural weakness and causes the loss of sand particles, and the cross-section of the water influx near the defect gradually expands with the loss of particles, indicating that there is a danger of further expansion of the defect under the impact of water flow. These results have technical implications for the management of water and sand leakage disasters in foundation pit engineering