Search for Solar Axions Produced in the p+d→3He+Ap + d \rightarrow\rm{^3He}+ A Reaction

A search for the axioelectric absorption of 5.5-MeV solar axions produced in the $p+d\rightarrow \rm{^3He}+\gamma(5.5 \rm{MeV})$ reaction was performed with two BGO detectors placed inside a low-background setup. A model independent limit on axion-photon and axion-nucleon couplings was obtained: $|g_{Ae}\times g_{AN}| \leq 3.2\times 10^{-9} (m_A=0)$. Constraints on the axion-electron coupling constant were obtained for axions with masses in the $(0.1-1.0)$ MeV range: $g_{Ae}\leq (1.8-9.0)\times 10^{-7}$. The solar positron flux from $A\rightarrow e^-+e^+$ decay was determined for axions with masses $m_A > 2m_e$. Using the existing experimental data on the interplanetary positron flux, a new constraint on the axion-electron coupling constant for axions with masses in the $(1.2-5.4)$ MeV range was obtained: $g_{Ae} \leq (1-5)\times 10^{-17}$.Comment: 6 pages, 5 figure

Pharmacokinetic profile of irinotecan in patients with chronic kidney disease:Two cases and literature review

Aims: There are limited pharmacokinetic data on the use of irinotecan in patients with reduced glomerular filtration rate (GFR) and no haemodialysis. In this case report, we present 2 cases and review the current literature. Methods: The dose of irinotecan in both patients was reduced pre-emptively due to reduced GFR. The first patient had her irinotecan dose reduced to 50%, but was nevertheless admitted to hospital because of irinotecan-induced toxicity, including gastrointestinal toxicity and neutropenic fever. The dose was reduced further to 40% for the second cycle; however, the patient was again admitted to the hospital, and irinotecan was stopped indefinitely. The second patient also had his irinotecan dose reduced to 50% and was admitted to the emergency department for gastrointestinal toxicity after the first cycle. However, irinotecan could be administered in the same dose in later cycles. Results: The area under the curve to infinity of irinotecan and SN-38 in the first patient were comparable to those of an individual receiving 100% dose intensity. The area under the curve to infinity of irinotecan and SN-38 in patient 2 in both cycles were slightly less than reference values. Furthermore, clearance values of irinotecan and SN-38 in our patients were comparable to those without renal impairment. Conclusion: Our case report suggests that reduced GFR may not significantly affect the clearance of irinotecan and SN-38, but can still result in clinical toxicity. Reduced initial dosing seems indicated in this patient population. Further research is needed to fully understand the relationship between reduced GFR, pharmacokinetics, and toxicity of irinotecan and SN-38.</p

Polarizing Bubble Collisions

We predict the polarization of cosmic microwave background (CMB) photons that results from a cosmic bubble collision. The polarization is purely E-mode, symmetric around the axis pointing towards the collision bubble, and has several salient features in its radial dependence that can help distinguish it from a more conventional explanation for unusually cold or hot features in the CMB sky. The anomalous "cold spot" detected by the Wilkinson Microwave Anisotropy Probe (WMAP) satellite is a candidate for a feature produced by such a collision, and the Planck satellite and other proposed surveys will measure the polarization on it in the near future. The detection of such a collision would provide compelling evidence for the string theory landscape.Comment: Published version. 15 pages, 8 figure

Singularly Perturbed Monotone Systems and an Application to Double Phosphorylation Cycles

The theory of monotone dynamical systems has been found very useful in the modeling of some gene, protein, and signaling networks. In monotone systems, every net feedback loop is positive. On the other hand, negative feedback loops are important features of many systems, since they are required for adaptation and precision. This paper shows that, provided that these negative loops act at a comparatively fast time scale, the main dynamical property of (strongly) monotone systems, convergence to steady states, is still valid. An application is worked out to a double-phosphorylation ``futile cycle'' motif which plays a central role in eukaryotic cell signaling.Comment: 21 pages, 3 figures, corrected typos, references remove

Spontaneous CP Violating Phase as The CKM Matrix Phase

We propose that the CP violating phase in the CKM mixing matrix is identical to the CP phases responsible for the spontaneous CP violation in the Higgs potential. A specific multi-Higgs model with Peccei-Quinn (PQ) symmetry is constructed to realize this idea. The CP violating phase does not vanish when all Higgs masses become large. There are flavor changing neutral current (FCNC) interactions mediated by neutral Higgs bosons at the tree level. However, unlike general multi-Higgs models, the FCNC Yukawa couplings are fixed in terms of the quark masses and CKM mixing angles. Implications for meson-anti-meson mixing, including recent data on $D-\bar D$ mixing, and neutron electric dipole moment (EDM) are studied. We find that the neutral Higgs boson masses can be at the order of one hundred GeV. The neutron EDM can be close to the present experimental upper bound.Comment: 16 pages, RevTex. Several typos corrected, and one reference adde

Time-distance analysis of the emerging active region NOAA 10790

We investigate the emergence of Active Region NOAA 10790 by means of time – distance helioseismology. Shallow regions of increased sound speed at the location of increased magnetic activity are observed, with regions becoming deeper at the locations of sunspot pores. We also see a long-lasting region of decreased sound speed located underneath the region of the flux emergence, possibly relating to a temperature perturbation due to magnetic quenching of eddy diffusivity, or to a dense flux tube. We detect and track an object in the subsurface layers of the Sun characterised by increased sound speed which could be related to emerging magnetic-flux and thus obtain a provisional estimate of the speed of emergence of around 1 km s−1

Photon, Neutrino and Charged Particle Spectra from R-violating Gravitino Decays

We study photonic, neutrino and charged particle signatures from slow decays of gravitino dark matter in supersymmetric theories where R-parity is explicitly broken by trilinear operators. Photons and (anti-)fermions from loop and tree-level processes give rise to spectra with distinct features, which, if observed, can give crucial input on the possible mass of the gravitino and the magnitude and flavour structure of R-violating operators. Within this framework, we make detailed comparisons of the theoretical predictions to the recent experimental data from PAMELA, ATIC and Fermi LAT.Comment: Version published in Phys. Lett.

Smooth metric measure spaces, quasi-Einstein metrics, and tractors

We introduce the tractor formalism from conformal geometry to the study of smooth metric measure spaces. In particular, this gives rise to a correspondence between quasi-Einstein metrics and parallel sections of certain tractor bundles. We use this formulation to give a sharp upper bound on the dimension of the vector space of quasi-Einstein metrics, providing a different perspective on some recent results of He, Petersen and Wylie.Comment: 33 pages; final versio