11 research outputs found
The partition of Korea after Word War II : A Global History : [book review]
No full textNon UBCUnreviewedOthe
Eastern Learning and the Heavenly Way: The Tonghak and Ch’ŏndogyo Movements and the Twilight of Korean Independence. By Carl F. Young. Honolulu: University of Hawai‘i Press, 2014. xxiii, 268 pp. $49.00 (cloth, ISBN 9780824838881).
No full textPolitical Leadership in Korea. Edited by Dae-sook Suh and Chae-jin Lee. Seattle and London: University of Washington Press, 1976. xvi, 272 pp. Appendix, Notes, Index. $9.50.
No full textNorth Koreans in Japan Today: Language, Ideology, and Identity. By Sonia Ryang. Boulder, Colo.: Westview Press, 1997. xix, 248 pp. $19.95 (paper).
No full textMin Yŏnghwan: The Selected Writings of a Late Chosŏn Diplomat. Translated by Michael Finch. Berkeley: Institute of East Asian Studies, University of California, 2008. 316 pp. $25.00 (paper).
No full textSocial Darwinism and Nationalism in Korea: The Beginnings (1880s–1910s): “Survival” as an Ideology of Korean Modernity. By Vladimir Tikhonov. Leiden and Boston: Brill, 2010. xii, 255 pp. $137.00 (cloth).
No full textPolitics and Policy in Traditional Korea. By James B. Palais. Cambridge, Mass.: Harvard University Press, 1975. 286 pp. Notes, Bibliography, Index. No price.
No full textNaval Surgeon in Yi Korea: The Journal of George W. Woods. By George W. Woods. Edited by Fred C. Bohm and Robert R. SwartoutJr., Berkeley: University of California, Institute of East Asian Studies, 1984. xiv, 137 pp. Illustrations, Appendixes, Notes, Bibliography, Glossary, Index. 22.50.
No full textCreative Women of Korea: The Fifteenth Through the Twentieth Centuries. Edited by Kim-Renaud Young-Key. Armonk, N.Y.: M. E. Sharpe, 2004. xiv, 250 pp. 24.95 (paper).
No full textExploring SK/S1P/S1PR pathway as a target for antiviral drug development
No full textSphingosine-1-phosphate (S1P) is a signal transmitter. The lipid sphingosine is converted to S1P by catalysis of Sphingosine kinase enzymes (SK1 or SK2). S1P acts extracellularly as a receptor ligand. The SK1/S1P axis plays important roles in cell signalling, the cell death/survival, the production of a pro-inflammatory response, and maintaining vascular integrity. There are five subtypes of S1P receptor known as S1P1, S1P2, S1P3, SP4, and S1P5. Glycosphingolipids promote viral entry. The drug molecules targeting the SK1/S1P axis such as fingolimod, ozanimod, and ponesimod are used for treatment of multiple sclerosis. S1P receptor modulator drug fingolimod shows antiviral activity against human immunodeficiency virus. Currently, the clinical trials of ozanimod (a sphingosine receptor modulator), and opaganib (a SK2 inhibitor) are being conducted for treatment of COVID-19. It is worth to target SK/S1P pathway to develop antiviral drugs, by repurposing existing inhibitors/modulators, and designing new specific inhibitors of SK1, SK2, and SP receptor
