The quality of antenatal care services in Shivrajpur block of district Kanpur: a community based survey

Background: India is amongst the top five countries in terms of absolute numbers of maternal deaths. In Uttar Pradesh MMR is even higher than national average. In spite of better utilisation of ante-natal services, pregnancy outcome is not significantly improving. Reason behind it is that worrying gaps in quality of antenatal care exist which lead to poor effectiveness of ANC in practice.  Methods: In the present study quality of antenatal care services utilised by 286 recently delivered women (RDWs) in last one year in Shivrajpur block of district Kanpur was conducted from August 2012 to July 2013. A predesigned questionnaire was used for data collection. Information regarding age, parity, and detailed history of antenatal care & place of antenatal care were collected after taking verbal consent.  Results: Majority (76.1%) of women were within 20 to 30 year of age who had delivered in last one year while 13.6% of women were within 20 year of age. In present study we find 91.9% coverage of antenatal care which was based on receiving at least one antenatal check-up. Majority (73.1%) of women received antenatal care from public facility (SC/PHC/CHC/Govt. Hospital). Out of 263 RDWs who received ANC, three-fourths had weight measurement (74.9%), their abdomen examined (76.4%) and hemoglobin estimation (69.6%) done. Less than two-thirds had height (60.8%) and blood pressure measured (66.2%). Nearly one of the two RDWs had urine examination (50.2%) and told about pregnancy complications & danger signs. Only 14.8% RDWs consumed 100 IFA tablet. TT injection was received by 79.5% of RDWs. Full ANC was taken by only 16.3% RDWs.Conclusion: Poor qualities of antenatal have a limited potential to affect maternal mortality. High-risk screening during antenatal care, as a means of identifying women for facility-based intra-partum care, is not effective for women who subsequently failed to obtain complete package of antenatal care.

The analysis of triglyceride-rich lipoproteins in human serum for clinical studies

Since cardiovascular disease is one of the leading causes of mortality all over the world, it is becoming increasingly important and relevant to develop new analytical techniques for the analysis of the mechanisms of this complex disease as well as for clinical applications. The overall objective of this research was to develop an array of methods for the analysis of triglyceride rich lipoproteins (TRL) in human serum and to apply these methods to clinical samples. TRL particles are mainly derived from dietary fats, which are positively correlated with cardiovascular disease. The mechanism behind which triglycerides cause cardiovascular disease is not well understood. The analysis of TRL by novel methods including density gradient ultracentrifugation and density profiling, gel electrophoresis, in vitro enzymatic assays, and capillary zone electrophoresis are presented here. The development of a novel density profiling method for the remnant lipoproteins class of TRL and its application to clinical samples was successful. In addition, TRL were successfully evaluated for their composition by gel electrophoresis, in vitro enzymatic assays and capillary zone electrophoresis. The results of these analyses demonstrate great potential for the use of these new methods as analytical tools for researchers in understanding the mechanism behind the onset of cardiovascular disease by TRL and their triglycerides as well as diagnostic tools for clinicians

Role of low dose danazol therapy for endometriosis related infertility and its comparison with laparoscopic fulguration in low resources

Background: The objective was to study the role of laparoscopic fulguration and danazol therapy for endometriosis in case of infertility followed by comparison of both therapies.Methods: The present cross–sectional study was conducted in the department of obstetrics and gynecology SN Medical College Agra. Over the period from December 2010 to November 2013. Symptomatic women (n=50) of age group 20-39 yrs coming to gynecology OPD were selected for study group. The study group was subjected to detailed history, physical examination laboratory test, ultrasound examination, and laparoscopy. Then 50 patients were allotted for laparoscopic fulguration and 50 for danazol treatment.Results: Out of 100 on transvaginal sonography, 10%of patient have cyst 2cm size, rest 70% have normal scan. On laparoscopy 52% of patient have red lesion, 16% have bluish black lesion, 20% have yellow brown lesion rest 22% have normal findings. On danazol therapy pelvic pain and dysmenorrhoea was relieved in 64% and 52% conceived .on laparoscopic fulguration symptom were relieved in 69% and 60% conceived.Conclusions: Based on this study it can be concluded that choice of therapy depend on age of patient,  duration of infertility, physical findings, goal of surgery, experience of surgeon and most important the  availability of resources. In this study result was comparable

Modified Rockall score: a predictor for outcome in patients presenting with upper gastrointestinal bleed

Background: Upper gastrointestinal bleeding (UGIB) is a life-threatening emergency with an overall mortality rate of around 10%. Complete Rockall score is designed to identify patients who are at greater risk of adverse outcome. The aim of this study was to assess the Rockall score as a predictor of adverse outcome in elderly population presenting with UGIB. Methods: Cross-sectional observational study to be carried out in indoor patients presenting with upper GI bleed and to study the correlation between Rockall score and outcome of patients at GSVM Medical College, Kanpur during 2020-2022. Results: Patients were grouped according to Rockall score with number of patients having score less than 3-13, 3-6-63, more than 6-18. Out of 120 cases, 56 (46.66%) had re-bleeding during hospital stay has an average score of 5.05 and rest 64 (53.33%) did not had re-bleeding and has a score of 4.11. Number of cases requiring having average score <3 has 8.1, score 3-6 has 8.38 and >6 has 9.67 has average hospital of stay (days). Number of cases requiring intensive care were 27 (22.5%) has 5.19 average Rockall score. Out of 120 studied cases, 101 (84.16%) were discharged has 4.29 and 19 (15.83%) were expired has 5.95 average Rockall score. Conclusions: Acute UGIB is a medical emergency and Rockall score is ideal to stratify elderly patients to anticipate outcome and prognosis

Multi-Task Meta Learning: learn how to adapt to unseen tasks

This work proposes Multi-task Meta Learning (MTML), integrating two learning paradigms Multi-Task Learning (MTL) and meta learning, to bring together the best of both worlds. In particular, it focuses simultaneous learning of multiple tasks, an element of MTL and promptly adapting to new tasks, a quality of meta learning. It is important to highlight that we focus on heterogeneous tasks, which are of distinct kind, in contrast to typically considered homogeneous tasks (e.g., if all tasks are classification or if all tasks are regression tasks). The fundamental idea is to train a multi-task model, such that when an unseen task is introduced, it can learn in fewer steps whilst offering a performance at least as good as conventional single task learning on the new task or inclusion within the MTL. By conducting various experiments, we demonstrate this paradigm on two datasets and four tasks: NYU-v2 and the taskonomy dataset for which we perform semantic segmentation, depth estimation, surface normal estimation, and edge detection. MTML achieves state-of-the-art results for three out of four tasks for the NYU-v2 dataset and two out of four for the taskonomy dataset. In the taskonomy dataset, it was discovered that many pseudo-labeled segmentation masks lacked classes that were expected to be present in the ground truth; however, our MTML approach was found to be effective in detecting these missing classes, delivering good qualitative results. While, quantitatively its performance was affected due to the presence of incorrect ground truth labels. The the source code for reproducibility can be found at https://github.com/ricupa/MTML-learn-how-to-adapt-to-unseen-tasks

CLINICAL STUDY ON MEDOROGA WITH SPECIAL REFERENCE TO VISESHA BY YAVAMALAKA CHURNA

The present era termed as age of Machines and Materialism has led to global economic advancement and affluence brought a drastic change in the life styles and living environment. Change in food habits, sedentary work, stressful environment etc. are the gifts of Industrialization to mankind. One side of life is happy with reduced physical activity and fat rich tasty food but the other side is showing affliction to chronic lifestyle disorders like diabetes mellitus, hypertension, cancer, ischemic heart disease, cerebro-vascular accidents, atherosclerosis, varicose veins etc. These diseases have been recognized as the leading killers of the millennium. Obesity is traced to be a major risk factor for these diseases. This study includes evaluate the applicability of concept of Visesha in Medoroga and clinical study on management of Medoroga by using Yavamalaka churna with special reference of Prakopana viparyayo hi dhatunam prasham karanam iti. Considering the above problem this study was planned the concept of Prakopana viparyayo hi dhatunam prasham karanam iti in the management of Medoroga with Yavamalaka churna because Medo dhatu is snigdha and guru in nature while Yava (Hordeum vulgarae) is Ruksha and Aguruand Amalaki (Emblica officinalis) also Ruksha in nature. The Amalaki has Tridoshahara properties especially Medohara. So these two drugs have opposite properties to medo dhatu. Hence due to the concept of Prakopana viparyayo hi dhatunam prashama karanam iti, yava and Amalaki cause the Hrasa of Medo dhatu

Distribution, Composition Profiles and Source Identification of Polycyclic Aromatic Hydrocarbons in Roadside Soil of Delhi, India

Distribution, composition profiles and sources of polycyclic aromatic hydrocarbons (PAHs) were evaluated in roadside soils from Delhi, India. PAH determination was made by Sonication extraction and chromatographic clean-up with final analysis by high performance liquid chromatography with ultraviolet-diode array detector (HPLC-UV-DAD).The average concentration of ∑PAHs was 6838.6±3528.4 µg kg-1 and ranged between 81.6 to 45017.4 µg kg-1. Seven possible carcinogenic PAHs (7c-PAHs) accounted 67.4% to the total PAHs. Diagnostic ratios of individual PAHs and LMWPAHs to HMWPAHs ratio were calculated and applied to assess the possible sources of PAHs which, indicates the mixed pyrogenic activities such as petroleum, biomass and coal combustion are the main contributors. Although, concentrations of individual PAHs were lower than the guideline values but, the concentrations of some high molecular weight PAHs were higher at the locations in the vicinity of industrial areas and there is probable some risk to human health. Keywords: Polycyclic aromatic hydrocarbons (PAHs), HPLC-UV, roadside soil, diagnostic ratio, Indi

Pengaruh Atmosferik terhadap Kepuasan dan Niatan Perilaku Konsumen

We study the atmospheric role at restaurant “X”, a Japanese chain restaurant in numerous Jakarta areas. More specifically, we analyze (1) the effect of atmospherics on service quality; (2) the effect of atmospherics on food quality; (3) the effect of atmospherics on perceived value; (4) the effect of service quality on customer satisfaction; (5) the effect of  perceived value on customer satisfaction; (6) the effect of  food quality on customer satisfaction; (7) the effect of  service quality on behavioral intentions; (8) the effect of  customer satisfaction on behavioral intentions; (9) the effect of  food quality on behavioral intentions, (10) indirect effect of atmospherics on customer satisfaction; and (11) indirect effect of atmospherics on behavioral intentions. We distributed questionnaires to customers of “X” restaurant and received back 283 questionnaires, of which 229 were usable for further analysis. Overall, the findings support all the hypotheses, except hypotheses (4) and  (7), probably because this is a self-service restaurant chain.Abstrak Penelitian ini dilakukan untuk mengetahui peran atmosferik di restoran “X,” sebuah restoran Jepang yang berada di berbagai area di Jakarta. Penelitian ini menganalisis (1) pengaruh atmosferik terhadap kualitas layanan; (2) pengaruh atmosferik terhadap kualitas makanan; (3) pengaruh atmosferik terhadap nilai yang dirasakan; (4) pengaruh kualitas layanan terhadap kepuasan pelanggan; (5) pengaruh nilai yang dirasakan terhadap kepuasan pelanggan; (6) pengaruh kualitas makanan terhadap kepuasan pelanggan; (7) pengaruh kualitas layanan terhadao niatan perilaku konsumen; (8) pengaruh kepuasan pelanggan terhadap niatan perilaku konsumen; (9) pengaruh kualitas makanan terhadap niatan perilaku konsumen; (10) pengaruh tidak langsung atmosferik terhadap kepuasan pelanggan; dan (11) pengaruh tidak langsung atmosferik terhadap niatan perilaku konsumen. Desain penelitian ini adalah kuantitatif. Kami membagikan kuesioner kepada para pelanggan restoran “X” di Jakarta dan kuesioner yang kembali berjumlah 283, yang mana ada 54 kuesioner yang tidak dapat digunakan, sehingga penelitian ini menggunakan 229 sampel. Setiap indikator terbukti sahih dan setiap variabel terbukti handal. Penelitian ini menemukan bahwa pengaruh atmosferik terhadap kualitas layanan, kualitas makanan, dan nilai yang dirakan secara parsial positif dan signifikan. Pengaruh nilai yang dirasakan dan kualitas makanan terhadap kepuasan pelanggan secara parsial juga positif dan signifikan. Pengaruh kepuasan pelanggan terhadap niatan perilaku konsumen positif dan signifikan. Pengaruh kualitas makanan terhadap niatan perilaku konsumen juga ditemukan positif dan signifikan. Pengaruh tidak langsung atmosferik terhadap kepuasan pelanggan dan niatan perilaku konsumen juga positif dan signifikan. Namun, karena di restoran yang diteliti konsumen mereka melayani diri sendiri, maka kualitas layanan tidak berpengaruh signifikan terhadap kepuasan pelanggan dan niatan perilaku konsumen

Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation

The spectrum of tumors that arise owing to the overexpression of c-Myc and loss of BLM is very similar. Hence, it was hypothesized that the presence of BLM negatively regulates c-Myc functions. By using multiple isogenic cell lines, we observed that the decrease of endogenous c-Myc levels that occurs in the presence of BLM is reversed when the cells are treated with proteasome inhibitors, indicating that BLM enhances c-Myc turnover. Whereas the N-terminal region of BLM interacts with c-Myc, the rest of the helicase interacts with the c-Myc E3 ligase Fbw7. The two BLM domains act as ‘clamp and/or adaptor’, enhancing the binding of c-Myc to Fbw7. BLM promotes Fbw7-dependent K48-linked c-Myc ubiquitylation and its subsequent degradation in a helicase-independent manner. A subset of BLM-regulated genes that are also targets of c-Myc were determined and validated at both RNA and protein levels. To obtain an in vivo validation of the effect of BLM on c-Myc-mediated tumor initiation, isogenic cells from colon cancer cells that either do or do not express BLM had been manipulated to block c-Myc expression in a controlled manner. By using these cell lines, the metastatic potential and rate of initiation of tumors in nude mice were determined. The presence of BLM decreases c-Myc-mediated invasiveness and delays tumor initiation in a mouse xenograft model. Consequently, in tumors that express BLM but not c-Myc, we observed a decreased ratio of proliferation to apoptosis together with a suppressed expression of the angiogenesis marker CD31. Hence, partly owing to its regulation of c-Myc stability, BLM acts as a ‘caretaker tumor suppressor’