HOMOGENEOUS MULTI-INTERFACE MOBILE NODE SUPPORT IN NS2

NS2 is a widely used, open source tool for network simulation. A Mobile Node (MN) in NS2 by default provides only a single Wi-Fi interface. It makes difficult for users to simulate the scenario where a mobile node is connected to multiple networks through different interfaces at the same time. Some projects have been done to implement multiple Wi-Fi interfaces but according to our view they have some limitations. This paper presents the implementation of mobile nodes in NS2 with multiple Wi-Fi interfaces and multiple WiMAX interfaces trying to overcome those limitations

SYNTHESIS, CHARACTERISATION AND EVALUATION OF SOME 1,5-BENZODIAZEPINE QUINOLIN-2-ONE DERIVATIVES AS POSSIBLE HYPNOTIC AGENTS.

A series of novel 3-(2-(phenyl/substituted phenyl)-1H-benzo[b] [1,5]-diazepin-4-yl)-4-methoxy-1-phenyl/methylquinolin-2(1H)-one [IV-a(1-6)/IV-b(1-6)] derivatives were synthesised by condensation of 3-substituted cinnamoyl-4-methoxy-1-phenyl/methylquinolin-2(1H)-one [III-a(1-6)/III-b(1-6)] with o-phenylenediamine. The results of the docking studies revealed that the synthesised compounds exhibited well conserved hydrogen bonding with one or more amino acid residues in the active pocket of alpha1beta3gamma2L GABA(A) Receptor (PDB ID: 6HUO) using Molegro Virtual Docker Software (MVD-2013, 6.0). The title compounds exhibited Mol Dock Score in the range of -124.502 to -149.448 with score more or comparable to the standard ligand score of -127.4127 and better than the standard drug -92.3878. All the synthesized compounds were satisfactorily characterized by spectral analysis and were tested for in vivo hypnotic activity based on the potentiation of barbiturate (phenobarbitone) sleeping time in miceusing diazepam as reference standard. All the compounds, except 4-methoxy-1-methyl-3-(2-(3-nitrophenyl)-1H-benzo[b][1,5]-diazepin-4-yl) quinolin-2(1H)-one (IV-b4), significantly decreased the sleep latency, prolonged the duration of sleep and also showed good muscle relaxation property. Among the synthesised compounds, 4-methoxy-3-(2-(3-methoxyphenyl)-1H-benzo[b][1,5]-diazepin-4-yl)-1-phenylquinolin-2(1H)-one (IV-a3) was found to be the most potenthypnotic agentwith sleep latency of 26.67 ± 2.629 min and sleeping time of 111.00 ± 6.028 minutesand matches with pharmacophore mapping of the designed molecule with the MolDock score

Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

Labour and society in Bombay 1918 - 1940 : Workplace, neighbourhood and social organization

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Ameloblastoma: Cytopathologic profile of 12 cases and literature review

Background: Fine-needle aspiration cytology (FNAC) has been used as a diagnostic tool in evaluating suspected lesions. It shows a high diagnostic accuracy for diagnosing salivary gland lesions. Aim: The aim of this study was to highlight FNAC as an effective diagnostic tool in the presumptive diagnosis of ameloblastoma. Materials and Methods: A total of 12 cases of ameloblastoma sampled by FNAC retrieved from the archives of the Oral Pathology Department were retrospectively studied. The smears were alcohol-fixed and stained with hematoxylin and eosin. All the 12 cases of FNAC had subsequent corresponding surgical incisional biopsy or excision specimens. Results: Cytologically, seven cases were diagnosed as benign odontogenic tumor more in favor of ameloblastoma. All the 12 fine-needle aspiration cases were given a histopathologic work-up and diagnosed as ameloblastomas. Of these, the seven cytologically diagnosed benign odontogenic lesions were also confirmed to be ameloblastoma by both incisional biopsy as well as surgical excision. Conclusion: It was deduced from the above results that FNAC helps potentially in diagnosing ameloblastoma