A retinal code for motion along the gravitational and body axes

Self-motion triggers complementary visual and vestibular reflexes supporting image-stabilization and balance. Translation through space produces one global pattern of retinal image motion (optic flow), rotation another. We examined the direction preferences of direction-sensitive ganglion cells (DSGCs) in flattened mouse retinas in vitro. Here we show that for each subtype of DSGC, direction preference varies topographically so as to align with specific translatory optic flow fields, creating a neural ensemble tuned for a specific direction of motion through space. Four cardinal translatory directions are represented, aligned with two axes of high adaptive relevance: the body and gravitational axes. One subtype maximizes its output when the mouse advances, others when it retreats, rises or falls. Two classes of DSGCs, namely, ON-DSGCs and ON-OFF-DSGCs, share the same spatial geometry but weight the four channels differently. Each subtype ensemble is also tuned for rotation. The relative activation of DSGC channels uniquely encodes every translation and rotation. Although retinal and vestibular systems both encode translatory and rotatory self-motion, their coordinate systems differ

Quantitative profiling of regional protein expression in rat retina after partial optic nerve transection using fluorescence difference two-dimensional gel electrophoresis

201910 bcmaVersion of RecordPublishe

Hospitalised care for patients with transient ischaemic attack (multiple letters)

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Regional and temporal patterns of retinal α-crystallins expression during secondary retinal ganglion cell degeneration.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.202205 bcfcMetadata onlyRGCOthersNIH/NEI Grant; Research to Prevent Blindness; General Research Funds; Henry G Leong Endowed Professorship Fund; PolyU Internal Grants; PolyUSeed FundPublishe

Regional and temporal patterns of retinal α-crystallines expression during secondary retinal ganglion cell degeneration

The Association for Research in Vision and Ophthalmology (ARVO) 2016 Annual Meeting, Seattle, Washington, USA, 1-5 May 20162015-2016 > Academic research: refereed > Refereed conference paper201812_a bcmaNot applicabl