Justifying public advocacy by charities: when does political activity become charitable?

Conference Theme: Democratization, Marketization, and the Third SectorIn common law jurisdictions, it has been a well-entrenched rule that charitable organizations must not substantially engage in political activities. Apart from party politics, these include, in American law, “attempt[s] to influence legislation” and in English law, the even broader formulation of “advocacy to change law or policy” ...postprin

Serving Alone: The Social Service Sector in Hong Kong: Annual Report on the Civil Society in Hong Kong 2009

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S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation.

Cigarette smoke induces injury and neutrophilic inflammation in the airways of smokers. The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD). We hypothesize that antagonizing HS/syndecan-1 binding of the inflammatory effectors could reduce smoking-related neutrophil-mediated airway inflammation. Analysis of bronchoalveolar lavage fluid(BALF) of COPD patients found both total and unopposed NE levels to be significantly higher among smokers with COPD than non-COPD subjects. Similar NE burden was observed in smoke-exposed rats compared to sham air controls. We chose sulfated-maltoheptaose(SM), a heparin-mimetic, to antagonize HS/sydecan-1 binding of the inflammatory mediators in airway fluids and lung tissues of the smoke-exposed rat model. Airway treatment with SM resulted in displacement of CINC-1 and NE from complexation with bronchio-epithelial HS/syndecan-1, dissipating the chemokine gradient for neutrophil flux across to the bronchial lumen. Following SM displacement of NE from shed HS/syndecan-1 in bronchial fluids, NE became accessible to inhibition by α1-antitrypsin endogenous in test samples. The antagonistic actions of SM against syndecan-1 binding of NE and CINC-1 in smoke-exposed airways suggest new therapeutic opportunities for modulating airway inflammation in smokers with SM delivery.published_or_final_versio

The role of circulating serotonin in the development of chronic obstructive pulmonary disease

Oral PresentationBACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The degree of cigarette smoking mediated the association between serotonin transporter (SERT) gene polymorphism and COPD. However, the interrelation between ...published_or_final_versionThe 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 n. 1, suppl. 1, p. 31, abstract no. 4

Induction of interleukin-6 secretion and matrix protein synthesis in human peritoneal mesothelial cells (HPMCs) by Pseudomonas aeruginosa exotoxin pyocyanin

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《學習2.0》：一個支援新高中通識教育及專題研究的學習及評估平臺

Liberal Studies as a mandatory subject in the New Secondary School curriculum will be implemented starting from September 2009. This subject adopts an inquiry-based approach and the content is structured around a range of important contemporary issues. Teachers face new challenges in teaching and assessing this subject: how to guide students to read critically, find useful information from the internet, formulate inquiry questions and to undertake evidence-based inquiry; how to support student collaboration and at the same time be able to assess the efforts and achievements of individual students; and how to provide adequate feedback to students at various stages of inquiry such that assessment can be both formative and summative. In addition, facilitating students to work autonomously online generally brings heavy workload on teachers. This paper introduces the Learning 2.0 project which comprises the development of an open-source online learning and assessment platform using Web 2.0 technology to provide support for the learning and teaching in the NSS Liberal Studies Curriculum.published_or_final_versio

Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity

Our recent study has indicated that Chinese green tea (Lung Chen), in which epigallocatechin-3-gallate (EGCG) accounts for 60% of catechins, protected cigarette smoke-induced lung injury. We now hypothesized that Lung Chen tea may also have potential effect on lung oxidative stress and proteases/anti-proteases in a smoking rat model. Sprague–Dawley rats were exposed to either sham air (SA) or 4% cigarette smoke (CS) plus 2% Lung Chen tea or water by oral gavage. Serine proteases, matrix metalloproteinases (MMPs) and their respective endogenous inhibitors were determined in bronchoalveolar lavage (BAL) and lung tissues by gelatin/casein zymography and biochemical assays. Green tea consumption significantly decreased CS-induced elevation of lung lipid peroxidation marker, malondialdehyde (MDA), and CS-induced up-regulation of neutrophil elastase (NE) concentration and activity along with that of α1-antitrypsin (α1-AT) and secretory leukoproteinase inhibitor (SLPI) in BAL and lung. In parallel, significant elevation of MMP-12 activity was found in BAL and lung of the CS-exposed group, which returned to the levels of SA-exposed group after green tea consumption but not CS-induced reduction of tissue inhibitor of metalloproteinase (TIMP)-1 activity, which was not reversed by green tea consumption. Taken together, our data supported the presence of local oxidative stress and protease/anti-protease imbalance in the airways after CS exposure, which might be alleviated by green tea consumption through its biological antioxidant activity. Read More: http://informahealthcare.com/doi/abs/10.3109/10715762.2012.692786postprin

The Natural and Built Environment Conservation Sector: Annual Report on the Civil Society in Hong Kong 2010

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Using Polyanionic Heparin Mimetics for the treatment of COPD

Poster Presentation - Theme 1: Cell biologyCOPD patients suffer from sustained inflammation leading to airway damage and deteriorating lung function caused by unopposed protease activity resulting from a1-antitrypsin resistant supramolecular complexes of neutrophil elastase and shed syndecan-1 in the airway. It was further shown that the action of the GAG digesting enzyme heparanase facilitates syndecan-1 shedding ...postprin