Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of ​interferon-λ4 (​IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis

Proceedings of The HKIE Geotechnical Division 41st Annual Seminar: Adapt to Challenges, Create to Thrive

This seminar proceedings contains articles on the various research ideas of the academic community and practitioners presented at The HKIE Geotechnical Division 41st Annual Seminar (GDAS2021). GDAS2021 was jointly organized by the Geotechnical Division, The Hong Kong Institution of Engineers, &amp; The Hong Kong Geotechnical Society on July 18th May 2021. Seminar Title: The HKIE Geotechnical Division 41st Annual SeminarSeminar Acronym: GDAS2021Seminar Date: 18 May 2021Seminar Location: Online (Virtual Mode)Seminar Organizers: Geotechnical Division, The Hong Kong Institution of Engineers, &amp; The Hong Kong Geotechnical Society