Bassani\u27s The Garden of the Finzi-Continis and Italian Queers

In his article Bassani\u27s The Garden of the Finzi-Continis and Italian \u27Queers\u27 John Champagne argues for a reading of the novel as not gay, but queer. Champagne argues that such a reading strategy emphasizes the ways in which the novel deconstructs normative gender, sexual, and even religious identities in an attempt both to resist the tyranny of the normal and to cope with the trauma of the Italian Shoah. A psycho-analytically inflected queer theory in this instance gives us access to the complexity of the novel\u27s portrayal of Italian Jewish identity in fascist Italy and opens up onto a reflection upon Jewish history and memory. In Bassani\u27s novel, Jewish and queer identities are linked in an effort to deconstruct (in the rigorous sense of the word) a version of the Italian Shoah that would hold Jews like the Finzi-Continis responsible for their own fate. It is thus misleading to suggest, as some other scholars have, that the novel is simply critical of the family. The Garden of the Finzi-Continis is read appropriately as Jewish not only in its content but in its form and queer in its invitation to understand an abnormal, anti-social world where useless pursuits like love (and art) justify and sanctify everything

Chasing a ghost : Addressing the opalescence/aggregation relationship of an IgG 1 antibody

This study was conducted to address the aggregation/opalescence relationship of an IgG 1 therapeutic antibody under a variety of conditions. The opalescence characteristics of three antibodies, Mab 1, 2 and 3, were examined as a function of salt dependence, protein concentration and temperature, using a variety of biophysical techniques. The high molecular weight species were initially identified using batch static and dynamic light scattering and separated by asymmetric flow field flow fractionation. When the salt dependence was examined, any structural changes were characterized using differential scanning calorimetry, circular dichroism and fluorescence, while the association state and temperature dependence was measured by viscometry. The resulting non-ideality was determined using multi-angle light scattering over a range of NaCl and protein concentration, and then used to assess the nature of the noncovalent association. In addition, the valence of the antibody therapeutics was directly measured using capillary electrophoresis and assessed as a predictive tool of non-ideal behavior. The antibody that exhibited the highest degree of opalescence, and therefore was the main focus of the study, was Mab 1, with Mab 3 exhibiting a lower degree of opalescence and Mab 2 acting as a control. The results suggest that the opalescence phenomenon of Mab 1 was due to a salt induced non-mass-action driven self-association which is mainly entropic in origin and is driven predominantly by NaCl. The intermolecular interactions appear to be facilitated by enhanced flexibility of Fc region and the independent Fab folding domain on Mab 1. The opalescence phenomenon also appears to be a relatively small fraction of discrete HMW material which is freely reversible and results in a liquid-liquid or liquid-solid phase transition which is either clear or cloudy depending on A2. Finally, it was determined that there is a discrepancy between the measured and calculated valence of the IgG1 antibodies in the study and this may be used as a predictive tool of non-ideal behavior. Together, this information was used to propose a model of the opalescence phenomenon of Mab 1 based on an electrostatic interaction involving mainly the CDR region on the Fab

Pressurised calcination-atmospheric carbonation of limestone for cyclic CO2 capture from flue gases

A study was carried out to investigate the CO2 capture performance of limestone under atmospheric carbonations following pressurised calcination. A series of tests was carried out to study the role of pressurised calcination using a fluidised bed reactor. In this investigation, calcination of limestone particles was carried out at three levels of pressure: 0.1 MPa, 0.5 MPa, and 1.0 MPa. After calcination, the capture performance of the calcined sorbent was tested at atmospheric pressure. As expected, the results indicate that the carbonation conversion of calcined sorbent decreases as the pressure is increased during calcination. Pressurised calcination requires higher temperatures and causes an increase in sorbent sintering, albeit that it would have the advantage of reducing equipment size as well as the compression energy necessary for CO2transport and storage, and an analysis has been provided to give an assessment of the potential benefits associated with such an option using process software.EPSR

Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial.

The objective of this clinical trial was to evaluate the effectiveness of zinc supplementation on diarrhea and average daily weight gain (ADG) in pre-weaned dairy calves. A total of 1,482 healthy Holstein heifer and bull calves from a large California dairy were enrolled at 24 to 48 hours of age until hutch exit at approximately 90 days of age. Calves were block-randomized by time to one of three treatments: 1) placebo, 2) zinc methionine (ZM), or 3) zinc sulfate (ZS) administered in milk once daily for 14 days. Serum total protein at enrollment and body weight at birth, treatment end, and hutch exit were measured. Fecal consistency was assessed daily for 28 days post-enrollment. For a random sample of 127 calves, serum zinc concentrations before and after treatment and a fecal antigen ELISA at diarrhea start and resolution for Escherichia coli K99, rotavirus, coronavirus, and Cryptosporidium parvum were performed. Linear regression showed that ZM-treated bull calves had 22 g increased ADG compared to placebo-treated bulls (P = 0.042). ZM-treated heifers had 9 g decreased ADG compared to placebo-treated heifers (P = 0.037), after adjusting for average birth weight. Sex-stratified models showed that high birth weight heifers treated with ZM gained more than placebo-treated heifers of the same birth weight, which suggests a dose-response effect rather than a true sex-specific effect of ZM on ADG. Cox regression showed that ZM and ZS-treated calves had a 14.7% (P = 0.015) and 13.9% (P = 0.022) reduced hazard of diarrhea, respectively, compared to placebo-treated calves. Calves supplemented for at least the first five days of diarrhea with ZM and ZS had a 21.4% (P = 0.027) and 13.0% (P = 0.040) increased hazard of cure from diarrhea, respectively, compared to placebo-treated calves. Logistic regression showed that the odds of microbiological cure at diarrhea resolution for rotavirus, C. parvum, or any single fecal pathogen was not different between treatment groups. Zinc supplementation delayed diarrhea and expedited diarrhea recovery in pre-weaned calves. Additionally, zinc improved weight gain differentially in bulls compared to heifers, indicating a research need for sex-specific dosing

Supply Chain Resilience: How Autonomous Rovers Empirically Provide Relief to Constrained Flight Line Maintenance Activities

Purpose – The purpose of this research is to explore the utility of autonomous transport across two independent airframe maintenance operations at a single location. Design/methodology/approach – This study leveraged discrete event simulation that encompassed real-world conditions on a United States Air Force flight line. Though the Theory of Constraints (TOC) lens, a high-demand, human-controlled delivery asset is analyzed and the impact of introducing an autonomous rover delivery vehicle is assessed. The authors’ simulations explored varying numbers and networks of rovers as alternative sources of delivery and evaluated these resources’ impact against current flight line operations. Findings – This research indicates that the addition of five autonomous rovers can significantly reduce daily expediter delivery tasks, which results in additional expertise necessary to manage and execute flight line operations. The authors assert that this relief would translate into enhancements in aircraft mission capable rates, which could increase overall transport capacity and cascade into faster cargo delivery times, systemwide. By extension, the authors suggest overall inventory management could be improved through reduction in transportation shipping time variance, which enhances the Department of Defense’s overall supply chain resilience posture. Originality/value – When compared against existing practices, this novel research provides insight into actual flight line movement and the potential benefits of an alternative autonomous delivery system. Additionally, the research measures the potential savings in the workforce and vehicle use that exceeds the cost of the rovers and their employment

Association between herd management practices and antimicrobial resistance in Salmonella spp. from cull dairy cattle in Central California.

BackgroundIn this study cull dairy cows from six California dairy herds were sampled seasonally over the course of a year. The objectives were to determine the prevalence of antimicrobial resistant (AMR) Salmonella spp. shed in cull cow feces, and the factors associated with fecal shedding of AMR and multidrug resistant (MDR) Salmonella.MethodsSix dairy farms located in the San Joaquin Valley of California were identified and enrolled as a convenience sample. On each dairy, and once during each of the four seasons, 10 cull cows were randomly selected for fecal sampling on the day of their removal from the herd. In addition, study personnel completed a survey based on responses of the herd manager to questions related to the previous 4 month's herd management and the specific cattle sampled. Fecal samples were submitted to the California Animal Health and Food Safety laboratory for Salmonella isolation. Antimicrobial resistance was evaluated using broth microdilution method and a gram-negative assay plate following Clinical Laboratory Standards Institute (CLSI) guidelines and breakpoint references. All statistical models were survey adjusted for number of animals on sampling day.ResultsA total of 62 Salmonella were isolated from 60 of the 239 fecal samples collected. For 12% (95% confidence interval (CI) [3-20]) of fecal samples a multidrug resistant Salmonella was isolated. The survey-weighted results for the two most common drug classes for which isolates were resistant were tetracycline (39%; 95% CI [27-51]) and ampicillin (18%; 95% CI [9-27]). An important finding was the identification of cephalosporin as the third most common drug class for which isolates were resistant, with ceftriaxone (10%; 95% CI [2-17]) being the most common drug associated with resistance in that class. At the cow-level, reason for culling, prior treatment with antimicrobial drugs as the reason for culling was associated with higher odds of isolating an AMR Salmonella isolate. At the herd-level, percent of animals monthly culled on the farm as well as number of milking cows in the herd were associated with isolation of antimicrobial resistant Salmonella in cull cows.DiscussionSalmonella isolated from fecal samples from cull cows were resistant to important antimicrobials, such as ceftriaxone. The most common drug classes for which isolates were resistant were tetracyclines and beta-lactams, with ampicillin, ceftriaxone and ceftiofur being the three most common drugs within the latter. Cow and herd level factors were associated with isolating antimicrobial resistant Salmonella that should be further investigated for their potential role in promoting occurrence of AMR Salmonella. Our results also highlight the importance of monitoring dairy cattle sent to slaughter for shedding of Salmonella resistant to medically important antimicrobial drugs