Topological B-Model on Weighted Projective Spaces and Self-Dual Models in Four Dimensions

It was recently shown by Witten on the basis of several examples that the topological B-model whose target space is a Calabi-Yau (CY) supermanifold is equivalent to holomorphic Chern-Simons (hCS) theory on the same supermanifold. Moreover, for the supertwistor space CP^{3|4} as target space, it has been demonstrated that hCS theory on CP^{3|4} is equivalent to self-dual N=4 super Yang-Mills (SYM) theory in four dimensions. We consider as target spaces for the B-model the weighted projective spaces WCP^{3|2}(1,1,1,1|p,q) with two fermionic coordinates of weight p and q, respectively - which are CY supermanifolds for p+q=4 - and discuss hCS theory on them. By using twistor techniques, we obtain certain field theories in four dimensions which are equivalent to hCS theory. These theories turn out to be self-dual truncations of N=4 SYM theory or of its twisted (topological) version.Comment: 12 pages; v2: minor clarification, 3 references added, published versio

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia:a Multinational Point Prevalence Study of Hospitalised Patients

Pseudornonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients

Parallel processing for panel methods

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