3,258 research outputs found
Two-dimensional colloidal fluids exhibiting pattern formation
Fluids with competing short range attraction and long range repulsive
interactions between the particles can exhibit a variety of microphase
separated structures. We develop a lattice-gas (generalised Ising) model and
analyse the phase diagram using Monte Carlo computer simulations and also with
density functional theory (DFT). The DFT predictions for the structures formed
are in good agreement with the results from the simulations, which occur in the
portion of the phase diagram where the theory predicts the uniform fluid to be
linearly unstable. However, the mean-field DFT does not correctly describe the
transitions between the different morphologies, which the simulations show to
be analogous to micelle formation. We determine how the heat capacity varies as
the model parameters are changed. There are peaks in the heat capacity at state
points where the morphology changes occur. We also map the lattice model onto a
continuum DFT that facilitates a simplification of the stability analysis of
the uniform fluid.Comment: 13 pages, 15 figure
Simplifying Algebra in Feynman Graphs, Part III: Massive Vectors
A T-dualized selfdual inspired formulation of massive vector fields coupled
to arbitrary matter is generated; subsequently its perturbative series modeling
a spontaneously broken gauge theory is analyzed. The new Feynman rules and
external line factors are chirally minimized in the sense that only one type of
spin index occurs in the rules. Several processes are examined in detail and
the cross-sections formulated in this approach. A double line formulation of
the Lorentz algebra for Feynman diagrams is produced in this formalism, similar
to color ordering, which follows from a spin ordering of the Feynman rules. The
new double line formalism leads to further minimization of gauge invariant
scattering in perturbation theory. The dualized electroweak model is also
generated.Comment: 39 pages, LaTeX, 8 figure
An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.
BACKGROUND: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore, not be acceptable to all study participants. OBJECTIVE: To design and evaluate an algorithm for detecting IgE-mediated food allergy in clinical study participants who do not undergo OFC. METHODS: An algorithm for trial participants in the Barrier Enhancement for Eczema Prevention (BEEP) study who were unwilling or unable to attend OFC was developed. BEEP is a pragmatic, multi-centre, randomized-controlled trial of daily emollient for the first year of life for primary prevention of eczema and food allergy in high-risk infants (ISRCTN21528841). We built on the European iFAAM consensus guidance to develop a novel food allergy diagnosis algorithm using available information on previous allergenic food ingestion, food reaction(s) and sensitization status. This was implemented by a panel of food allergy experts blind to treatment allocation and OFC outcome. We then evaluated the algorithm's performance in both BEEP and Enquiring About Tolerance (EAT) study participants who did undergo OFC. RESULTS: In 31/69 (45%) BEEP and 44/55 (80%) EAT study control group participants who had an OFC the panel felt confident enough to categorize children as "probable food allergy" or "probable no food allergy". Algorithm-derived panel decisions showed high sensitivity 94% (95%CI 68, 100) BEEP; 90% (95%CI 72, 97) EAT and moderate specificity 67% (95%CI 39, 87) BEEP; 67% (95%CI 39, 87) EAT. Sensitivity and specificity were similar when all BEEP and EAT participants with OFC outcome were included. CONCLUSION: We describe a new algorithm with high sensitivity for IgE-mediated food allergy in clinical study participants who do not undergo OFC. CLINICAL RELEVANCE: This may be a useful tool for excluding food allergy in future clinical studies where OFC is not conducted
SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma
SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20Gy/5#) or dose escalated treatment (36Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM
Artificial Brains and Hybrid Minds
The paper develops two related thought experiments exploring variations on an âanimatâ theme. Animats are hybrid devices with both artificial and biological components. Traditionally, âcomponentsâ have been construed in concrete terms, as physical parts or constituent material structures. Many fascinating issues arise within this context of hybrid physical organization. However, within the context of functional/computational theories of mentality, demarcations based purely on material structure are unduly narrow. It is abstract functional structure which does the key work in characterizing the respective âcomponentsâ of thinking systems, while the âstuffâ of material implementation is of secondary importance. Thus the paper extends the received animat paradigm, and investigates some intriguing consequences of expanding the conception of bio-machine hybrids to include abstract functional and semantic structure. In particular, the thought experiments consider cases of mind-machine merger where there is no physical Brain-Machine Interface: indeed, the material human body and brain have been removed from the picture altogether. The first experiment illustrates some intrinsic theoretical difficulties in attempting to replicate the human mind in an alternative material medium, while the second reveals some deep conceptual problems in attempting to create a form of truly Artificial General Intelligence
Cubic Twistorial String Field Theory
Witten has recently proposed a string theory in twistor space whose
D-instanton contributions are conjectured to compute N=4 super-Yang-Mills
scattering amplitudes. An alternative string theory in twistor space was then
proposed whose open string tree amplitudes reproduce the D-instanton
computations of maximal degree in Witten's model.
In this paper, a cubic open string field theory action is constructed for
this alternative string in twistor space, and is shown to be invariant under
parity transformations which exchange MHV and googly amplitudes. Since the
string field theory action is gauge-invariant and reproduces the correct cubic
super-Yang-Mills interactions, it provides strong support for the conjecture
that the string theory correctly computes N-point super-Yang-Mills tree
amplitudes.Comment: 19+1 pages, 4+1 EPS figures, JHEP3 LaTeX; v2: minor corrections,
references added; v3: the final version published in JHEP with a new footnote
on the d=0 on-shell contributio
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Regional and monthly and clear-sky aerosol direct radiative effect (and forcing) derived from the GlobAEROSOL-AATSR satellite aerosol product
Using the GlobAEROSOL-AATSR dataset, estimates
of the instantaneous, clear-sky, direct aerosol radiative
effect and radiative forcing have been produced for the year
2006. Aerosol Robotic Network sun-photometer measurements
have been used to characterise the random and systematic
error in the GlobAEROSOL product for 22 regions covering
the globe. Representative aerosol properties for each
region were derived from the results of a wide range of literature sources and, along with the de-biased GlobAEROSOL
AODs, were used to drive an offline version of the Met Office unified model radiation scheme. In addition to the mean AOD, best-estimate run of the radiation scheme, a range of additional calculations were done to propagate uncertainty estimates in the AOD, optical properties, surface albedo and errors due to the temporal and spatial averaging of the AOD fields. This analysis produced monthly, regional estimates of the clear-sky aerosol radiative effect and its uncertainty, which were combined to produce annual, global mean values of (â6.7±3.9)Wmâ2 at the top of atmosphere (TOA) and (â12±6)Wmâ2 at the surface. These results were then used to give estimates of regional, clear-sky aerosol direct radiative forcing, using modelled pre-industrial AOD fields for the year 1750 calculated for the AEROCOM PRE experiment. However, as it was not possible to quantify the uncertainty in the pre-industrial aerosol loading, these figures can only be taken as indicative and their uncertainties as lower bounds on the likely errors. Although the uncertainty on aerosol radiative effect presented here is considerably larger than most previous estimates, the explicit inclusion of the major sources of error in the calculations suggest that they are closer to the true constraint on this figure from similar methodologies, and point to the need for more, improved estimates of both global aerosol loading and aerosol optical properties
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