Human Body as a Multicrine System, with Special Reference to Cell Protein Secretion: From Vascular Smooth Muscles to Adipose Tissue

The lecture was presented on 23 November 2016at Biomedical Forum 27 (2016-2017) in Medical University, VarnaPart 1: https://www.youtube.com/watch?v=aj3U-kgLh9wPart 2: https://www.youtube.com/watch?v=pfcDor3G70

Editor's Foreword

The Hierarchy of Data-Information-Knowledge-Wisdom as an epistemological system is usually associated with Russell Ackoff (1) although elements of it are envisaged in poetic form by T.S. Eliot in his 1934 `The Rock`:Where is the Life we have lost in living?Where is the wisdom we have lost in knowledge?Where is the knowledge we have lost in information?Today we may add one more question: `Where is the intellectual humility and reciprocal respect we have lost in competition and in `publish or perish` paradigm?` Reminding Theodore Roszak who wrote in 1972: `In the conditions of spiritual disintegration in which we live, modern man is in search of a soul` (2). And inside the latter - the empathy. Indeed, Homo economicus rather than Homo empathicus is a global psychosocial phenomenon (3 and essays therein)

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Instructions to Author

Editor's Foreword

Dear Colleagues,In October 2015, Professor Maria Staykova at The John Curtin College of Medicine, Biology and Environment, Australian National University, Canberra, Australia sent to me a verse entitled Brain created by child from fourth class:With the brain man thinks that thinks.Moreover the brain is used for headache.Located in the head, behind the nose.When someone sneezes, it drips.The brain is very sensitive organ.For this reason people use it rarely.In December 2015, Professor Hiroshi Yamamoto at Department of Biochemistry and Vascular Biology, Kanazawa University, Kanazawa, Japan wrote to me:Dear George,I wish you health, happiness and something fantastic in 2016.Enclosed is my hope for this year - it‘s called „Sousei`, meaning „live together`.*HiroI immediately replied:Hiro, after the wishes for health, your „Sousei` - to live together in mutual understanding - is the most important message to all people in the world. Because:Brain and heart are very sensitive organs.For this reason people should use them more often - together.George, BHF-ly yoursGeorge N. Chaldako

Editor's foreword

Emily Dickinson`s 632 poem may, in the language of adipobiology, be brie!y paraphrased as BMI (brain mass index) is wider than BMI (body mass index).We argue strongly for the creation of a bridge between the virtues of intellect (brain) and those of feeling (heart/ soul), desig- nating such a bridge brain-and-heart friendship (BHF). Even as a brain-and-heart family. Onward, the larger the BHF, the better for the society including scienti"c community.Thus BHF might indeed be considered The Fifth Element, the quintessence (Latin quinta - "ve, and essentia - the true nature of being) (1). The dynamic and plasticity of The Elements have been expressed by ancient Greek philosophers in the following aphorism: Nothing new comes or can come into being: the only change that can occur is a change in the juxtaposition of element with element.Imaging humans as elements, we should work together on Human Phiolome (Friendome) Project (2). Herein illustrated by a collage called Friendorama, a masterpiece of Dr Vesselka Nikolova, a cardiologist in Varna, Bulgaria and Göttingen, Germany

Instructions to Authors

General Information about the magazine Biomedical Reviews (BMR), prepared by the Bulgarian Society for Cell Biology (BGSCB) and published by the Medical University Press, Varna, Bulgaria.General instructions regarding the organization of the manuscript, the title page, the abstracts, as well as the introduction, the captions, the conclusion, and the references of each article.Instructions for the authors who would like to publish their work in Biomedical Reviews. Details about the: illustrations, preparation of tables, figure legends, abbreviations, proofs, offprints, and page charges

Editor's foreword

It is a pleasure to express our 2017 best wishes to you, families and friends forHealthy and Creative Longevity!!!MODUS VIVENDI, FOXO, KLOTHO AND SIR ARE FRIEND