The physical and biological factors that influence the isomerization of lycopene

grantor: University of TorontoEpidemiological and dietary intervention studies demonstrate an inverse relationship between the consumption of tomato and tomato products and the incidence of cancer. The overall aim of this thesis was to evaluate the effect of physical and biological factors that influence lycopene isomerization. Following results were observed: (1) All-'trans' lycopene was the predominant isomer in tomatoes, tomato products and supplement. (2) Heating tomato juice in the presence of olive oil enhanced 'cis' isomerization of lycopene. (3) Tissue and serum samples had higher levels of ' cis'-isomers. (4) Peak lymph concentration of lycopene was observed 6 hours post-administration. These results suggest that 'cis'-isomers of lycopene may be responsible for the protective effect in the prevention of cancer and cardiovascular diseases.M.Sc