chanches of the immune organs under demielinization and remielinization.

The purpose of work was to study the morphological changes in thymus and spleen at experimental allergic encephalomyelitis (EAE) and after «Rebif» (interferon β-1a) treatment. With this aim the thymus and spleen of adult rats in 21 and 39 days after initiation of EAE were used. After 14th day induction of EAE “Rebif” was injected subcutaneous in doses: 0,55 mcg daily during 4 days, 1,1 mg daily during 3 days, 0,55 mcg each other day during 15 days. The square of correlation of cortex and medullar parts of lobules of thymus, white and red pulpas of spleen was measured, the calculation of cellular composition of thymus and spleen. The researches showed that the destructive and reactive changes develop in the organs of the immune system at EAE which correlate with the changes in the organs of the nervous system. The pathological changes of thymus and spleen after the EAE initiation are related to the demielinization changes in the nervous fibres of organs of the central nervous system. We conclude the influence of the «Rebif» at EAE was immunosuppressive and accelerates reparation processes in thymus and spleen

Theoretical aspects of an innovation strategy development for metallurgical enterprises

Критичний аналіз існуючих трактувань «інноваційна стратегія», «стратегія інноваційного розвитку» та застосування процесного підходу дозволило поглибити останнє поняття, а саме, представити його як процес реалізації стратегії, виокремити інструменти реалізації (комплекс новітніх засобів та методів реалізації), уточнити умови реалізації (турбулентність зовнішнього середовища) та визначити кінцеву мету (підвищення конкурентоспроможності підприємства й досягнення якісно нового становища). Розгляд реалізації інноваційної стратегії розвитку як одного з процесів управління, дозволив визначити й охарактеризувати його інформаційне, методичне та організаційне забезпечення.The analysis of scientific publications of domestic and foreign scholars has shown that the concept «an innovation strategy» and the concept «a strategy of innovative development» have been often equated. Critical analyses of existing understanding of these concepts and the use of process approach have allowed us to precise the concept «innovative strategy of development». In the contrast to existing understanding, we propose to consider it as the process of a strategy realization, define tools for its implementation (the complex of modern techniques and methods), precise the conditions of its realization (turbulence of environment) and define the final objective of its application (increasing the competitiveness of an enterprise). On the basis of the analysis of income and outcome information flows we have defined interconnection and interdependence of the processes of formation and implementation of an innovation strategy of an enterprise development as well as required information, methodological and organizational support, defined the ways of possible improvement

Binary Classification of Heart Failures Using k-NN with Various Distance Metrics

Magnetocardiography is a sensitive technique of measuring low magnetic fields generated by heart functioning, which is used for diagnostics of large number of cardiovascular diseases. In this paper, k-nearest neighbor (k-NN) technique is used for binary classification of myocardium current density distribution maps (CDDM) from patients with negative T-peak, male and female patients with microvessels (diffuse) abnormalities and sportsmen, which are compared with normal control subjects. Number of neighbors for k-NN classifier was selected to obtain highest classification characteristics. Specificity, accuracy, precision and sensitivity of classification as functions of number of neighbors in k-NN are obtained for classification with several distance measures: Mahalanobis, Cityblock, Eucleadian and Chebyshev. Increase of the accuracy of classification for all groups up to 10% was obtained using Cityblock distance metric in binary k-NN classifier with 19 - 27 neighbors, comparing to other metrics. Obtained results are acceptable for further patient’s state evaluation

Evaluation of the Lidar/Radiometer Inversion Code (LIRIC) to determine microphysical properties of volcanic and desert dust

© Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 LicenseThe Lidar/Radiometer Inversion Code (LIRIC) combines the multiwavelength lidar technique with sun/sky photometry and allows us to retrieve vertical profiles of particle optical and microphysical properties separately for fine-mode and coarse-mode particles. After a brief presentation of the theoretical background, we evaluate the potential of LIRIC to retrieve the optical and microphysical properties of irregularly shaped dust particles. The method is applied to two very different aerosol scenarios: a strong Saharan dust outbreak towards central Europe and an Eyjafjallajökull volcanic dust event. LIRIC profiles of particle mass concentrations for the coarse-mode as well as for the non-spherical particle fraction are compared with results for the non-spherical particle fraction as obtained with the polarization-lidar- based POLIPHON method. Similar comparisons for fine-mode and spherical particle fractions are presented also. Acceptable agreement between the different dust mass concentration profiles is obtained. LIRIC profiles of optical properties such as particle backscatter coefficient, lidar ratio, Ångström exponent, and particle depolarization ratio are compared with direct Raman lidar observations. Systematic deviations between the LIRIC retrieval products and the Raman lidar measurements of the desert dust lidar ratio, depolarization ratio, and spectral dependencies of particle backscatter and lidar ratio point to the applied spheroidal-particle model as main source for these uncertainties in the LIRIC results.Peer reviewe

Hybrid MHD/PIC simulation of a metallic gas-puff z pinch implosion

We present the hybrid MHD/PIC simulations of the time evolution of a bismuth metallic gas-puff z pinch in external axial magnetic field (AMF). Recent experiments with IMRI-5 generator (450 kA, 450 ns) [1] show the certain effect of an axial magnetic field on radiation energy produced during z pinch implosion. In order to perform the numerical simulation of gas puff z pinch a hybrid model was developed. The hybrid model treats the electrons as a massless fluid and ions as macroparticles. The macroparticle dynamic is calculated with the use of PIC method. Ion-ion Coulomb collision is considered with the use of MC method. The radiation transfer of bismuth plasma was accounted in the framework of P1 method. The interelectrode gap pumping by plasma of 8 μs 80 kA bismuth arc with the following plasma implosion by 450 kA / 450 ns current pulse in different external AMF was modelled. The obtained results are in a reasonable agreement with the experimental results. © Published under licence by IOP Publishing Ltd.The work was supported by Russian Science Foundation (project No. 16-19-10142)

Interface Nerve Tissue-Silicon Nanowire for Regeneration of Injured Nerve and Creation of Bio-Electronic Device

This overview presents the results of scientific and practical research into the development of the interface “neuron-electronic device” based on silicon nanowire. The work has been carried out for several years by a team of scientists specializing in various fields of science and technology: neuroscience, surface science, nanoelectronics, crystal growth, physics and chemistry of nanotechnology, and nanocomputing. The technology of formation of the interface “nerve fiber-silicon nanowire” was developed. The experiments were performed in vivo on Wistar rats. The developed technology was used in the manufacture of implants for the regeneration of the injured sciatic nerve. The results of the studies showed the effectiveness of using such implants not only for the regeneration of nerves with severe injuries but also for the creation of a bioelectronic interface for neurocomputers that can be used in vivo for a long time

Smart hystology

Department of Histology and Embryology Bogomolets National Medical University, Kyiv, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 75 de ani de la fondarea Universităţii de Stat de Medicină și Farmacie Nicolae Testemiţanu, Chişinău, 30-31 octombrie 2020Abstract The review presents the experience of teaching histology in practical classes at a medical university, which involves the use of new pedagogical approaches in problem-oriented self-education, the formation of professional practical skills in future medical workers, their acquisition of the ability to interpret in detail the diagnostic criteria of histological structures in normal conditions, as well as their changes in the process of adaptation, compensation and possible pathological changes. The article discloses and substantiates innovative technologies that contribute to improving the efficiency and quality of education, as well as ensuring the creation of pedagogical conditions for students to adapt to the education system and improve the formation of tools for the development of their clinical thinking., Expanding communication opportunities. Histology and embryology were integrated with other basic scientific disciplines during the first two years of study at the university. Due to Smart technology the Nikon E200 Microscope application with a WiFi camera for tandem microscopy, each student has the opportunity to be coordinated and self-oriented, to be able to fully demonstrate initiative, independence, creative research and to be more interactive while differentiating histological preparations in discussing and solving problematic scientific issues of medical importance