311 research outputs found
Natural infection of phlebotomines (Diptera: Psychodidae) in a visceral-leishmaniasis focus in Mato Grosso do Sul, Brazil
Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization
Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1(-/-)) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1(-/-) exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of neurolysin (NLN). Peptidomic analysis identifies differences in intracellular peptide ratios between THOP1(-/-) and WT mice, which may affect normal cellular functioning. In an experimental model of multiple sclerosis THOP1(-/-) mice present worse clinical behavior scores compared to WT mice, corroborating its possible involvement in neurodegenerative diseases. THOP1(-/-) mice also exhibit better survival and improved behavior in a sepsis model, but also a greater peripheral pain sensitivity measured in the hot plate test after bradykinin administration in the paw. THOP1(-/-) mice show depressive-like behavior, as well as attention and memory retention deficits. Altogether, these results reveal a role of THOP1 on specific behaviors, immune-stimulated neurodegeneration, and infection-induced inflammation
Vegetative growth of grasslands based on hyper-temporal NDVI data from the Modis sensor
Desempenho de tambaqui cultivado em tanques-rede, em lago de várzea, sob diferentes taxas de alimentação
Rendimento de feijão e alterações no pH e na matéria orgânica do solo em função de doses de composto de resíduo de algodão
Suscetibilidade de Rhipicephalus (Boophilus) microplus a carrapaticidas em Mato Grosso do Sul, Brasil
Changes on physiological parameters of tambaqui (Colossoma macropomum) fed with diets supplemented with Amazonian fruit Camu camu (Myrciaria dubia)
Mineração de dados para inferência de relações solo-paisagem em mapeamentos digitais de solo
Estudos sôbre reservatórios e vetores silvestres do Trypanosoma cruzi: XVII. Contribuição para o estudo dos focos naturais da tripanossomose americana, com especial referência à região nordeste do Estado de São Paulo, Brasil
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