3,752 research outputs found

    Nonexistence of self-similar singularities for the 3D incompressible Euler equations

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    We prove that there exists no self-similar finite time blowing up solution to the 3D incompressible Euler equations. By similar method we also show nonexistence of self-similar blowing up solutions to the divergence-free transport equation in Rn\Bbb R^n. This result has direct applications to the density dependent Euler equations, the Boussinesq system, and the quasi-geostrophic equations, for which we also show nonexistence of self-similar blowing up solutions.Comment: This version refines the previous one by relaxing the condition of compact support for the vorticit

    Asymmetry in fatigue and recovery in ferroelectric Pb(Zr,Ti)O3 thin-film capacitors

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    We investigate the fatigue and refreshment by dc-electrical field of the electrical properties of Pt/Pb(Ti,Zr)O3_3/Pt ferroelectric capacitors. We find an asymmetry in the refreshment, that is, the fatigued state can be refreshed by application of negative high dc-voltage to the top electrode, but no refreshment is measured by positive dc-voltage application. We also find that the fatigue can be prevented by driving the capacitor asymmetrically.Comment: 4 pages, 5 figure

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    Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death

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    <p>Abstract</p> <p>Background</p> <p>Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibinin induces glioma cell death and its effect was effectively prevented by calpain inhibitor. The present study was therefore undertaken to examine the role of calpain in the silibinin-induced glioma cell death.</p> <p>Methods</p> <p>U87MG cells were grown on well tissue culture plates and cell viability was measured by MTT assay. ROS generation and △ψ<sub>m </sub>were estimated using the fluorescence dyes. PKC activation and Bax expression were measured by Western blot analysis. AIF nuclear translocation was determined by Western blot and immunocytochemistry.</p> <p>Results</p> <p>Silibinin induced activation of calpain, which was blocked by EGTA and the calpain inhibitor Z-Leu-Leu-CHO. Silibinin caused ROS generation and its effect was inhibited by calpain inhibitor, the general PKC inhibitor GF 109203X, the specific PKC<sub>δ </sub>inhibitor rottlerin, and catalase. Silibinin-induce cell death was blocked by calpain inhibitor and PKC inhibitors. Silibinin-induced PKC<sub>δ </sub>activation and disruption of △ψ<sub>m </sub>were prevented by the calpain inhibitor. Silibinin induced AIF nuclear translocation and its effect was prevented by calpain inhibitor. Transfection of vector expressing microRNA of AIF prevented the silibinin-induced cell death.</p> <p>Conclusions</p> <p>Silibinin induces apoptotic cell death through a calpain-dependent mechanism involving PKC, ROS, and AIF nuclear translocation in U87MG human glioma cells.</p

    On the global well-posedness for the Boussinesq system with horizontal dissipation

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    In this paper, we investigate the Cauchy problem for the tridimensional Boussinesq equations with horizontal dissipation. Under the assumption that the initial data is an axisymmetric without swirl, we prove the global well-posedness for this system. In the absence of vertical dissipation, there is no smoothing effect on the vertical derivatives. To make up this shortcoming, we first establish a magic relationship between urr\frac{u^{r}}{r} and ωθr\frac{\omega_\theta}{r} by taking full advantage of the structure of the axisymmetric fluid without swirl and some tricks in harmonic analysis. This together with the structure of the coupling of \eqref{eq1.1} entails the desired regularity.Comment: 32page

    Strong lensing constraints on the velocity dispersion and density profile of elliptical galaxies

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    We use the statistics of strong gravitational lensing from the CLASS survey to impose constraints on the velocity dispersion and density profile of elliptical galaxies. This approach differs from much recent work, where the luminosity function, velocity dispersion and density profile were typically {\it assumed} in order to constrain cosmological parameters. It is indeed remarkable that observational cosmology has reached the point where we can consider using cosmology to constrain astrophysics, rather than vice versa. We use two different observables to obtain our constraints (total optical depth and angular distributions of lensing events). In spite of the relatively poor statistics and the uncertain identification of lenses in the survey, we obtain interesting constraints on the velocity dispersion and density profiles of elliptical galaxies. For example, assuming the SIS density profile and marginalizing over other relevant parameters, we find 168 km/s < sigma_* < 200 km/s (68% CL), and 158 km/s < sigma_* < 220 km/s (95% CL). Furthermore, if we instead assume a generalized NFW density profile and marginalize over other parameters, the slope of the profile is constrained to be 1.50 < beta < 2.00 (95% CL). We also constrain the concentration parameter as a function of the density profile slope in these models. These results are essentially independent of the exact knowledge of cosmology. We briefly discuss the possible impact on these constraints of allowing the galaxy luminosity function to evolve with redshift, and also possible useful future directions for exploration.Comment: Uses the final JVAS/CLASS sample, more careful choice of ellipticals, added discussion of possible biases. Final results essentially unchanged. Matches the MNRAS versio
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