What’s the story? Outdoor education in New Zealand in the 21st century

Outdoor education, in its various guises, has been part of the New Zealand education system for decades and is considered by many to be integral to school life. This paper addresses outdoor education within physical education in primary and secondary schools. It critiques the priority historically given to personal and social outcomes, suggesting that this has served to keep outdoor pursuits and adventure activities at the forefront of many school programmes, particularly in secondary schools. In turn, it is proposed that this has sidetracked the focus from outdoor environmental education, a problematic outcome given contemporary concerns about the need to foster environmental appreciation, understanding, and action. A range of possibilities for a practice of outdoor education that deliberately and creatively fuses simple, 'skill-full' adventures, and student connectedness and commitment to local environments is highlighted

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype

Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical HD phenotype without the expected mutation. The objective of this study was to assess the occurrence of diseases such as Huntington’s disease-like 2 (HDL2), spinocerebellar ataxia (SCA) 1, SCA2, SCA3, SCA7, dentatorubral-pallidoluysian atrophy (DRPLA) and choreaacanthocytosis (ChAc) among 29 Brazilian patients with a HD-like phenotype. In the group analyzed, we found 3 patients with HDL2 and 2 patients with ChAc. The diagnosis was not reached in 79.3% of the patients. HDL2 was the main cause of the HD-like phenotype in the group analyzed, and is attributable to the African ancestry of this population. However, the etiology of the disease remains undetermined in the majority of the HD negative patients with HD-like phenotype. Key words: Huntington’s disease, Huntington’s disease-like, chorea-acanthocytosis, Huntington’s disease-like 2

Key competencies: Views from the gym floor.

The release of The New Zealand Curriculum (2007) will inevitably yield challenges and possibilities for teachers of Physical Education in both primary and secondary schools. In this paper I describe the vision and key competencies embedded in this new curriculum and discuss their relationship to Physical Education. Drawing on the voices of secondary school students, I interrogate the opportunities that students envisage for developing key competencies in Physical Education. I propose that students can, and do, afford significant insight into how teachers may enact key competencies in curriculum learning and that it is critical thinking that will enable both students and teachers to understand and relate to the movement culture in meaningful and relevant ways

Physical education in primary schools: holding on to the past or heading for a different future?

This paper reports on research undertaken by Pétrie, jones, and McKlm (2007)' during 2006, as part of a Ministry of Education funded evaluation ofthe Impacts of professional learning on currlcular and co-currlcular physical activity. While the evaluative research explored physical activity In the broadest sense, this paper concentrates specifically on the aspect ofthe research that focussed on physical education [PEj as a curriculum subject. The paper provides a snapshot of how PE ¡s understood and practised by generallst teachers In ten primary schools. It then identifies some of the factors that contribute to interpretations and delivery of PE, and Issues that need to be addressed If PE is to move beyond the past and towards an alternative future

Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium

Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences their biomechanical properties which are crucial for the cells to pass the microvasculature. Here, we investigated blood cell deformability of five ChAc patients compared to healthy controls during up to 1-year individual off-label treatment with the tyrosine kinase inhibitor dasatinib or several weeks with lithium. Measurements with two microfluidic techniques allowed us to assess RBC deformability under different shear stresses. Furthermore, we characterized leukocyte stiffness at high shear stresses. The results showed that blood cell deformability–including both RBCs and leukocytes - in general was altered in ChAc patients compared to healthy donors. Therefore, this study shows for the first time an impairment of leukocyte properties in ChAc. During treatment with dasatinib or lithium, we observed alterations in RBC deformability and a stiffness increase for leukocytes. The hematological phenotype of ChAc patients hinted at a reorganization of the cytoskeleton in blood cells which partly explains the altered mechanical properties observed here. These findings highlight the need for a systematic assessment of the contribution of impaired blood cell mechanics to the clinical manifestation of ChAc

Youth and Vegetative Renewal in Ancient Maya Religious Ideology

The role of children in ancient Maya religion and ritual was predicated upon the qualities of youth and vitalization that children possess. Furthermore, their role was rooted in associations between these possessed qualities, phenomena of agricultural renewal, and broader conceptions of life forces and cycles. These shared qualities created links between religious ideas about young children, agricultural sustenance, and ensoulment processes. Ethnohistoric and ethnographic accounts relating to ritualized child socialization provide details for parallel arguments on the ancient social and religious status of Maya children. Ideological connections can also be directly inferred from ancient Maya art, and can be interpreted from the archaeological remains left by the material traces of ritual practices such as child sacrifice. From this evidence, theories about the possible sacred status of young children in ancient Maya religion can be drawn. Furthermore, an examination of the socio-religious implications for the inclusion of children in Maya ritual as sacrificial victims may reveal that this inclusion was significant for the continuation of more widely encompassing ideological principles; namely for the continuance of annual and agricultural cycles. Through such an examination, this paper argues for the explicit recognition of the sacredness of children in ancient Maya religion, a generally underrepresented demographic in current archaeological studies

Facial cellulitis revealing choreo-acanthocytosis: A case report

We report a 62 year-old-man with facial cellulitis revealing choreo-acanthocytosis (ChAc). He showed chorea that started 20 years ago. The orofacial dyskinisia with tongue and cheek biting resulted in facial cellulitis. The peripheral blood smear revealed acanthocytosis of 25%. The overall of chorea, orofacial dyskinetic disorder, peripheral neuropathy, disturbed behavior, acanthocytosis and the atrophy of caudate nuclei was suggestive of a diagnosis of ChAc. To our knowledge no similar cases of facial cellulitis revealing choreo-acanthocytosis  (ChAc) were found in a review of the literature.Key words: Choreo-acanthocytosis, facial cellulitis, dyskinetic movement

Cyclohexadione-aniline conjugate inhibits proliferation of melanoma cells via upregulation of Mek 1/2 kinase activity

Purpose: To investigate the antiproliferative effect of cyclohexadione-aniline conjugate (CHAC) on melanoma cells, and the mechanism of action involved. Methods: Human melanoma cell lines (B16 F1 and A375) were used in this study. The cells were cultured in RPMI 1640 medium supplemented with 10 % fetal bovine serum (FBS) and 1 % penicillin/streptomycin at 37 °C in a humidified atmosphere of 5 % CO2 and 95 % air. After attaining 70 - 80 % confluency, the cells were treated with serum-free medium and graded concentrations of CHAC (10 – 60 μM) for 24 h. Normal cell culture without CHAC served as control group. B16 F1 and A375 cells were used in logarithmic growth phase in this study. Cell viability and apoptosis were assessed using 3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphe¬nyltetrazolium bromide (MTT) and flow cytometric assays, respectively. Western blotting was used to assess the levels of protein expression of X linked inhibitor of apoptosis (XIAP), survivin, p-Erk 1/2, and p-Mek 1/2. Results: Treatment of B16 F1 and A375 cells with CHAC led to significant and concentrationdependent reductions in their viability (p < 0.05). The proliferation of B16 F1 cells decreased from 93.41 to 32.87 %, while that of A375 cells was reduced from 95.23 to 36.50 %. Treatment of B16 F1 cells with CHAC significantly and concentration-dependently increased the population of cells in G0/G1 phase, and significantly reduced cell proportion in S and G2/M phases (p < 0.05). It also significantly and concentration-dependently promoted apoptosis in B16 F1 cells (p < 0.05). CHAC treatment significantly and concentration-dependently down-regulated the expressions of XIAP and survivin proteins (p < 0.05). Exposure of B16 F1 cells to CHAC significantly and concentration-dependently upregulated the expression of p-Mek 1/2, but down-regulated p-Erk 1/2 protein expression (p < 0.05). Densitometric analysis revealed that the expression of p-Mek 1/2 was increased from 12 to 91 %. Conclusion: The results of this study indicate that CHAC inhibits the proliferation of melanoma cells via upregulation of Mek 1/2 kinase activity, and therefore may find application in the management of melanoma

Debris control design achievements of the booster separation motors

The stringent debris control requirements imposed on the design of the Space Shuttle booster separation motor are described along with the verification program implemented to ensure compliance with debris control objectives. The principal areas emphasized in the design and development of the Booster Separation Motor (BSM) relative to debris control were the propellant formulation and nozzle closures which protect the motors from aerodynamic heating and moisture. A description of the motor design requirements, the propellant formulation and verification program, and the nozzle closures design and verification are presented