Dynamical switching characteristics of a bistable injection laser

The switching characteristics of a bistable injection laser with very large hysteresis is examined. Switch-on delays are shown to exhibit a "critical" part and a "noncritical" part, both of which can be reduced by increasing the overdrive current. It is possible to obtain fairly fast switching time (<20 ns) with a strong overdrive. Nominal delays of 100–200 ns result under moderate overdrives. These long time scales are due to long carrier lifetimes in the carrier-depleted absorption section, a property intrinsic to these bistable injection lasers

Bistability and pulsations in cw semiconductor lasers with a controlled amount of saturable absorption

Experimental results of a buried heterostructure cw laser with a controllable amount of saturable absorption introduced by a segmented contact are presented. With no absorption the laser is stable and has a linear output characteristic. Increasing of the saturable absorption by changing the pump current through the control segment causes the light output of the device to pulsate and to show bistable and hysteretical behavior. The introduction of a controllable amount of saturable absorption suggest the usefulness of this device in generating extremely short pulses, for example, by passive mode locking and as a bistable optical device

Longitudinal mode spectrum of GaAs injection lasers under high-frequency microwave modulation

Experimental observations of the lasing spectrum of a single mode semiconductor laser under continuous microwave modulation reveal that the lasing spectrum is apparently locked to a single longitudinal mode for optical modulation depths up to ~80%, beyond which the lasing spectrum becomes multimoded, whose envelope width increases very rapidly with further increase in modulation depth. These results are satisfactorily explained by a theoretical treatment which enables one to predict the dynamic lasing spectrum of a laser from its cw lasing spectra at various output powers

Bistability and negative resistance in semiconductor lasers

Experimental results of a buried heterostructure laser with a segmented contact to achieve inhomogeneous gain are presented. Measurements reveal a negative differential resistance over the absorbing section. Depending on the source impedance of the dc current source driving the absorbing section, this negative resistance can lead to (i) bistability with a very large hysteresis in the light-current characteristic without self-pulsation or (ii) a small hysteresis with self-pulsations at microwave frequencies. An analysis, which includes the electrical part of the device, leads to an explanation of self-pulsations in inhomogeneously pumped lasers without having to rely on a sublinear gain dependence on injected carrier concentration

Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9

CRISPR systems build adaptive immunity against mobile genetic elements by DNA capture and integration catalysed by Cas1–Cas2 protein complexes. Recent studies suggested that CRISPR repeats and adaptation module originated from a novel type of DNA transposons called casposons. Casposons encode a Cas1 homologue called casposase that alone integrates into target molecules single and double-stranded DNA containing terminal inverted repeats (TIRs) from casposons. A recent study showed Methanosarcina mazei casposase is able to integrate random DNA oligonucleotides, followed up in this work using Acidoprofundum boonei casposase, from which we also observe promiscuous substrate integration. Here we first show that the substrate flexibility of Acidoprofundum boonei casposase extends to random integration of DNA without TIRs, including integration of a functional gene. We then used this to investigate targeting of the casposase-catalysed DNA integration reactions to specific DNA sites that would allow insertion of defined DNA payloads. Casposase–Cas9 fusions were engineered that were catalytically proficient in vitro and generated RNA-guided DNA integration products from short synthetic DNA or a gene, with or without TIRs. However, DNA integration could still occur unguided due to the competing background activity of the casposase moiety. Expression of Casposase-dCas9 in Escherichia coli cells effectively targeted chromosomal and plasmid lacZ revealed by reduced β-galactosidase activity but DNA integration was not detected. The promiscuous substrate integration properties of casposases make them potential DNA insertion tools. The Casposase–dCas9 fusion protein may serves as a prototype for development in genetic editing for DNA insertion that is independent of homology-directed DNA repair

Direct amplitude modulation of short-cavity GaAs lasers up to X-band frequencies

Experimental and theoretical studies indicate that a high-frequency laser with bandwidths up to X-band frequencies (~> 10 GHz) should be one having a short cavity with a window structure, and preferably operating at low temperatures. These designs would accomplish the task of shortening the photon lifetime, increasing the intrinsic optical gain, and increasing the internal photon density without inflicting mirror damage. A modulation bandwidth of >8 GHz has been achieved using a 120-µm laser without any special window structure at room temperature

Superluminescent damping of relaxation resonance in the modulation response of GaAs lasers

It is demonstrated experimentally that the intrinsic modulation response of injection lasers can be modified by reducing mirror reflectivities, which leads to suppression of relaxation oscillation resonance and a reduction of nonlinear distortions up to multi-GHz frequencies. A totally flat response with a 3-dB bandwidth of 5 GHz was obtained using antireflection coated buried heterostructure lasers fabricated on a semi-insulating substrate. Harmonic distortions were below 40 dB within the entire 3-dB bandwidth. These results are in accord with theoretical predictions based on an analysis which include the effects of superluminescence in the laser cavity

Rapid-eye-movement-sleep (REM) associated enhancement of working memory performance after a daytime nap

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Non-invasive quantification of physiological processes with dynamic PET using blind deconvolution

Author name used in this publication: Daniel Pak-Kong LunAuthor name used in this publication: Dagan FengVersion of RecordPublishe