Conservative evaluation of the uncertainty in the LAGEOS-LAGEOS II Lense-Thirring test

We deal with the test of the general relativistic gravitomagnetic Lense-Thirring effect currently ongoing in the Earth's gravitational field with the combined nodes \Omega of the laser-ranged geodetic satellites LAGEOS and LAGEOS II. One of the most important source of systematic uncertainty on the orbits of the LAGEOS satellites, with respect to the Lense-Thirring signature, is the bias due to the even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's geopotential which account for the departures from sphericity of the terrestrial gravitational potential induced by the centrifugal effects of its diurnal rotation. The issue addressed here is: are the so far published evaluations of such a systematic error reliable and realistic? The answer is negative. Indeed, if the difference \Delta J_L among the even zonals estimated in different global solutions (EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, ITG-Grace02, ITG-Grace03s, JEM01-RL03B, EGM2008, AIUB-GRACE01S) is assumed for the uncertainties \delta J_L instead of using their more or less calibrated covariance sigmas \sigma_{J_L}, it turns out that the systematic error \delta\mu in the Lense-Thirring measurement is about 3 to 4 times larger than in the evaluations so far published based on the use of the sigmas of one model at a time separately, amounting up to 37% for the pair EIGEN-GRACE02S/ITG-Grace03s. The comparison among the other recent GRACE-based models yields bias as large as about 25-30%. The major discrepancies still occur for J_4, J_6 and J_8, which are just the zonals the combined LAGEOS/LAGOES II nodes are most sensitive to.Comment: LaTex, 12 pages, 12 tables, no figures, 64 references. To appear in Central European Journal of Physics (CEJP

Experimental Vacuum Squeezing in Rubidium Vapor via Self-Rotation

We report the generation of optical squeezed vacuum states by means of polarization self-rotation in rubidium vapor following a proposal by Matsko et al. [Phys. Rev. A 66, 043815 (2002)]. The experimental setup, involving in essence just a diode laser and a heated rubidium gas cell, is simple and easily scalable. A squeezing of 0.85+-0.05 dB was achieved

Unstaged cancer in the United States: a population-based study

<p>Abstract</p> <p>Background</p> <p>The current study examines unstaged disease for 18 cancer sites in the United States according to the influence of age, sex, race, marital status, incidence, and lethality.</p> <p>Methods</p> <p>Analyses are based on 1,040,381 male and 1,011,355 female incident cancer cases diagnosed during 2000 through 2007. Data were collected by population-based cancer registries in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program.</p> <p>Results</p> <p>The level of unstaged disease was greater in more lethal cancers (e.g., liver, esophagus, and pancreas) compared with less deadly cancers (i.e., colon, urinary bladder, and female breast). Unstaged disease increased with age and is greater among non-married patients. Blacks compared with whites experienced significantly higher levels of unstaged cancers of the stomach, rectum, colon, skin (melanoma), urinary bladder, thyroid, breast, corpus, cervix, and ovaries, but lower levels of unstaged liver, lung and bronchial cancers. Males compared with females experienced significantly lower levels of unstaged cancers of the liver, pancreas, esophagus, and stomach, but significantly higher levels of unstaged lung and bronchial cancer and thyroid cancer. The percent of unstaged cancer significantly decreased over the study period for 15 of the 18 cancer sites.</p> <p>Conclusion</p> <p>Tumor staging directly affects treatment options and survival, so it is recommended that further research focus on why a decrease in unstaged disease did not occur for all of the cancer sites considered from 2000 to 2007, and why there are differential levels of staging between whites and blacks, males and females for several of the cancer sites.</p

Will the recently approved LARES mission be able to measure the Lense-Thirring effect at 1%?

After the approval by the Italian Space Agency of the LARES satellite, which should be launched at the end of 2009 with a VEGA rocket and whose claimed goal is a about 1% measurement of the general relativistic gravitomagnetic Lense-Thirring effect in the gravitational field of the spinning Earth, it is of the utmost importance to reliably assess the total realistic accuracy that can be reached by such a mission. The observable is a linear combination of the nodes of the existing LAGEOS and LAGEOS II satellites and of LARES able to cancel out the impact of the first two even zonal harmonic coefficients of the multipolar expansion of the classical part of the terrestrial gravitational potential representing a major source of systematic error. While LAGEOS and LAGEOS II fly at altitudes of about 6000 km, LARES will be placed at an altitude of 1450 km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS II. Their corrupting impact \delta\mu has been evaluated by using the standard Kaula's approach up to degree L=70 along with the sigmas of the covariance matrices of eight different global gravity solutions (EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, JEM01-RL03B, ITG-Grace02s, ITG-Grace03, EGM2008) obtained by five institutions (GFZ, CSR, JPL, IGG, NGA) with different techniques from long data sets of the dedicated GRACE mission. It turns out \delta\mu about 100-1000% of the Lense-Thirring effect. An improvement of 2-3 orders of magnitude in the determination of the high degree even zonals would be required to constrain the bias to about 1-10%.Comment: Latex, 15 pages, 1 table, no figures. Final version matching the published one in General Relativity and Gravitation (GRG

How to reach a few percent level in determining the Lense-Thirring effect?

In this paper we discuss and compare a node-only LAGEOS-LAGEOS II combination and a node-only LAGEOS-LAGEOS II-Ajisai-Jason1 combination for the determination of the Lense-Thirring effect. The new combined EIGEN-CG01C Earth gravity model has been adopted. The second combination cancels the first three even zonal harmonics along with their secular variations but introduces the non-gravitational perturbations of Jason1. The first combination is less sensitive to the non-conservative forces but is sensitive to the secular variations of the uncancelled even zonal harmonics of low degree J4 and J6 whose impact grows linearly in time.Comment: Latex2e, 22 pag. 1 table, 2 figures, 45 references. Changes in the Abstract, Introduction and Conclusions. Discussion on the non-gravitational perturbations on Ajisai and on the impact of the secular rates of the even zonal harmonics added. EIGEN-CG01C CHAMP+GRACE+terrestrial gravimetry/altimetry Earth gravity model used. Reference adde

τ\tauSPECT: A spin-flip loaded magnetic ultracold neutron trap for a determination of the neutron lifetime

The confinement of ultracold neutrons (UCNs) in a three dimensional magnetic field gradient trap allows for a measurement of the free neutron lifetime with superior control over spurious loss channels and can provide a large kinetic energy acceptance to enhance statistical sensitivity. In this paper, we present the first successful implementation of a pulsed spin-flip based loading scheme for a three-dimensional magnetic UCN trap. The measurements with the $\tau$SPECT experiment were performed at the pulsed UCN source of the research reactor TRIGA Mainz. We report on detailed investigations of major systematic effects influencing the neutron storage time, statistically limited by the size of the recorded data set. The extracted neutron storage time constant of $\tau = 859(16)\mathrm{s}$ is compatible with, but not to be interpreted as, a measurement of the free neutron lifetime.Comment: 15 pages, 19 figure

Phenomenology of the Lense-Thirring effect in the Solar System

Recent years have seen increasing efforts to directly measure some aspects of the general relativistic gravitomagnetic interaction in several astronomical scenarios in the solar system. After briefly overviewing the concept of gravitomagnetism from a theoretical point of view, we review the performed or proposed attempts to detect the Lense-Thirring effect affecting the orbital motions of natural and artificial bodies in the gravitational fields of the Sun, Earth, Mars and Jupiter. In particular, we will focus on the evaluation of the impact of several sources of systematic uncertainties of dynamical origin to realistically elucidate the present and future perspectives in directly measuring such an elusive relativistic effect.Comment: LaTex, 51 pages, 14 figures, 22 tables. Invited review, to appear in Astrophysics and Space Science (ApSS). Some uncited references in the text now correctly quoted. One reference added. A footnote adde

An Assessment of the Systematic Uncertainty in Present and Future Tests of the Lense-Thirring Effect with Satellite Laser Ranging

We deal with the attempts to measure the Lense-Thirring effect with the Satellite Laser Ranging (SLR) technique applied to the existing LAGEOS and LAGEOS II terrestrial satellites and to the recently approved LARES spacecraft.The first issue addressed here is: are the so far published evaluations of the systematic uncertainty induced by the bad knowledge of the even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's geopotential reliable and realistic? Our answer is negative. Indeed, if the differences Delta J_L among the even zonals estimated in different Earth's gravity field global solutions from the dedicated GRACE mission are assumed for the uncertainties delta J_L instead of using their covariance sigmas sigma_JL, it turns out that the systematic uncertainty \delta\mu in the Lense-Thirring test with the nodes Omega of LAGEOS and LAGEOS II may be up to 3 to 4 times larger than in the evaluations so far published ($5-10$) based on the use of the sigmas of one model at a time separately. The second issue consists of the possibility of using a different approach in extracting the relativistic signature of interest from the LAGEOS-type data. The third issue is the possibility of reaching a realistic total accuracy of 1% with LAGEOS, LAGEOS II and LARES, which should be launched in November 2009 with a VEGA rocket. While LAGEOS and LAGEOS II fly at altitudes of about 6000 km, LARES will be likely placed at an altitude of 1450 km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS II. Their corrupting impact has been evaluated with the standard Kaula's approach up to degree L=60 by using Delta J_L and sigma_JL; it turns out that it may be as large as some tens percent.Comment: LaTex, 19 pages, 1 figure, 12 tables. Invited and refereed contribution to The ISSI Workshop, 6-10 October 2008, on The Nature of Gravity Confronting Theory and Experiment in Space To appear in Space Science Review

Neutrophils in cancer: neutral no more

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets