ANALYSING THE USERS` PERCEPTION OF WEB DESIGN QUALITY BY DATA MINING TOOLS

Several authors indicated the existence of different relative importance of each web site quality factor across e-business domains and between stakeholders. They also found the correlation between web site quality and e-business performance . The website with the highest quality produced the highest business performance. Therefore there is a need to constantly monitor users’ behavior and their requirements in different e-business sector towards better web site design. The aim of this research is to explore possibilities of classification data mining tools to support and automate process of discovering users` perception of web site design quality factors. In order to do that we collected 81 cases that serve as an input for inductive reasoning. We applied modified ID3 algorithm and induced the most informative attributes and rules describing users` perception of web design quality for online travel agency. The findings can provide the management and web designers with useful insights to enhance and refine their business performance

Self-regulation of the endothelin receptor system in choriocarcinoma cells

AbstractThe human trophoblast secretes endothelin-1 (ET-1) and expresses ET receptors. The present study tested whether the transformed BeWo, JAR and JEG-3 choriocarcinoma cells: (1) secrete endothelin-1 (ET-1); (2) express both ET-A and ET-B receptor subtypes; and (3) have the potential to allow for autologous regulation of ET-receptor proteins. The cells were cultured for 24/48 h with or without 10% FCS and, in experiments on receptor regulation, with ET-1 (5–20 nM and 10 μM). ET-1 secretion was measured by RIA and receptor levels by immunoblotting. All cell types secreted ET-1 albeit at different levels and sensitivity to FCS. All cell lines expressed both ET-A (JEG-3>BeWo=JAR) and ET-B (JEG-3=JAR>BeWo) receptor subtypes, which could be up- and downregulated depending on ET-1 concentration, culture time and FCS presence. It is concluded that BeWo, JAR and JEG-3 choriocarcinoma cells secrete ET-1 and express both ET-A and ET-B receptor subtypes. The receptor levels can be regulated by ET-1. This provides the molecular basis for an autocrine system with the potential of autologous regulation of yet unidentified ET-1-induced functions

Лингвостилистическая организация дискурсивной стратегии продвижения университета в сопоставительном аспекте (на основе анализа сайтов российского и китайского вузов)

Объект исследования - университетский дискурс. Цель работы — выявление особенностей лингвостилистической организации дискурсивной стратегии продвижения на сайтах вузов РФ и КНР. В процессе исследования проводились дискурсивный, лингвистический, стилистический, сопоставительный анализ коммуникативной стратегии продвижения вузов. В результате исследования были выявлены лингвистические и стилистические особенности оформления жанров сайтов вузов, реализующих стратегию продвижения, проведен сопоставительный анализ, выработаны рекомендации по переводу. Область применения: переводческая практика переводов и разработки внешних версий сайтов вузов. Экономическая эффективность/значимость работы заключается в предоставлении рекомендаций по переводу сайтов в аспекте продвижения вуза.Object of research: university discourse. Aim of research is to determine linguistic and stylistic features of promotion as a discourse strategy conducted on websites of Russian and Chinese universities. The following activities were carried out inn the course of the research: discourse analysis, linguistic, stylistic and comparative analysis of the communication strategy of universities promotion. Research results: linguistic and stylistic features of universities websites genres that use communication strategy of promotion were determined, comparative analysis was carried out, translation recommendations were provided. Appliance scope: translational practice of translation and design of universities foreign language versions

Metrization of pro-morphism sets

Every pair of inverse systems X, Y in a category A, where Y is cofinite, admits a complete (ultra)metric structure on the set pro-A(X,Y). The corresponding hom-bifunctor is not, generally, an internal Hom. However, there exists a subcategory of pro-A, containing tow-A, for which the hom-bifunctor is an invariant Hom into the category of complete metric spaces. Application to the sets tow-HcANR(X,Y) yields several new interesting results concerning Borsuk\u27s quasi-equivalence

A core outcome set for studies of gestational diabetes mellitus prevention and treatment

AIMS/HYPOTHESIS: The aim of this systematic review was to develop core outcome sets (COSs) for trials evaluating interventions for the prevention or treatment of gestational diabetes mellitus (GDM). METHODS: We identified previously reported outcomes through a systematic review of the literature. These outcomes were presented to key stakeholders (including patient representatives, researchers and clinicians) for prioritisation using a three-round, e-Delphi study. A priori consensus criteria informed which outcomes were brought forward for discussion at a face-to-face consensus meeting where the COS was finalised. RESULTS: Our review identified 74 GDM prevention and 116 GDM treatment outcomes, which were presented to stakeholders in round 1 of the e-Delphi study. Round 1 was completed by 173 stakeholders, 70% (121/173) of whom went on to complete round 2; 84% (102/121) of round 2 responders completed round 3. Twenty-two GDM prevention outcomes and 30 GDM treatment outcomes were discussed at the consensus meeting. Owing to significant overlap between included prevention and treatment outcomes, consensus meeting stakeholders agreed to develop a single prevention/treatment COS. Fourteen outcomes were included in the final COS. These consisted of six maternal outcomes (GDM diagnosis, adherence to the intervention, hypertensive disorders of pregnancy, requirement and type of pharmacological therapy for hyperglycaemia, gestational weight gain and mode of birth) and eight neonatal outcomes (birthweight, large for gestational age, small for gestational age, gestational age at birth, preterm birth, neonatal hypoglycaemia, neonatal death and stillbirth). CONCLUSIONS/INTERPRETATION: This COS will enable future GDM prevention and treatment trials to measure similar outcomes that matter to stakeholders and facilitate comparison and combination of these studies. TRIAL REGISTRATION: This study was registered prospectively with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/studies/details/686/

Response to Plasmapheresis Measured by Angiogenic Factors in a Woman with Antiphospholipid Syndrome in Pregnancy

An imbalance of angiogenic and antiangiogenic placental factors such as endoglin and soluble fms-like tyrosine kinase 1 has been implicated in the pathophysiology of preeclampsia. Extraction of these substances by plasmapheresis might be a therapeutical approach in cases of severe early-onset preeclampsia. Case Report. A 21-year-old primigravida with antiphospholipid syndrome developed early-onset preeclampsia at 18 weeks’ gestation. She was treated successfully with plasmapheresis in order to prolong pregnancy. Endoglin and sflt-1-levels were measured by ELISA before and after treatment. Endoglin levels decreased significantly after treatment (p < 0.05) and showed a significant decrease throughout pregnancy. A rerise of endoglin and sflt-1 preceded placental abruption 4 weeks before onset of incident. Conclusion. Due to the limited long-term therapeutical possibilities for pregnancies complicated by PE, plasmapheresis seems to be a therapeutical option. This consideration refers especially to pregnancies with early-onset preeclampsia, in which, after first conventional treatment of PE, prolongation of pregnancy should be above all

Case Report Response to Plasmapheresis Measured by Angiogenic Factors in a Woman with Antiphospholipid Syndrome in Pregnancy

An imbalance of angiogenic and antiangiogenic placental factors such as endoglin and soluble fms-like tyrosine kinase 1 has been implicated in the pathophysiology of preeclampsia. Extraction of these substances by plasmapheresis might be a therapeutical approach in cases of severe early-onset preeclampsia. Case Report. A 21-year-old primigravida with antiphospholipid syndrome developed early-onset preeclampsia at 18 weeks&apos; gestation. She was treated successfully with plasmapheresis in order to prolong pregnancy. Endoglin and sflt-1-levels were measured by ELISA before and after treatment. Endoglin levels decreased significantly after treatment (p &lt; 0.05) and showed a significant decrease throughout pregnancy. A rerise of endoglin and sflt-1 preceded placental abruption 4 weeks before onset of incident. Conclusion. Due to the limited long-term therapeutical possibilities for pregnancies complicated by PE, plasmapheresis seems to be a therapeutical option. This consideration refers especially to pregnancies with early-onset preeclampsia, in which, after first conventional treatment of PE, prolongation of pregnancy should be above all