Are we spending too much to grow? The case of Structural Funds

We evaluate whether the impact of EU Structural and Cohesion Funds (EUF) on Member States’ regional economic growth depends on the intensity of treatment, measured by the normalized amount of funds distributed in each region. We use an original dataset that covers all the main sources of EUF and extend the regression discontinuity design to the case of continuous treatment. The results suggest an average positive effect on regional growth. The estimated conditional intensity-growth function is concave and presents a maximum value. Therefore, the exceeding funds could have been allocated to other lagging regions without reducing the effect on growth

Identifying Variation in Learner Outcomes by Further Education Provider

This report presents results of a project to investigate how the labour market outcomes secured by individual learners vary across Further Education (FE) Providers. The research is the latest in a series of studies previously commissioned by BIS (now BEIS) of ILR-WPLS1 administrative data that estimate the value added of Further Education, as reflected in the Earnings, Employment and Benefit premiums secured by FE learners. This programme of investigation identifies good labour market returns to FE learning, and compelling evidence that previous less favourable findings (relating to vocationally- oriented learning at Level 2 and below) were a result of data limitations, rather than insignificant value added

Returns to Maths and English Learning (at level 2 and below) in Further Education

Previous work identifies good labour market returns for FE learners who gain qualifications at Full Level 2 and above. Estimates of the returns to learning at ‘Below Level 2’ and ‘Thin Level 2’ - which include English and Maths qualifications - were positive but not so strong – though it should be noted that many of these qualifications are of a very short duration. This report presents the findings from a project that investigates labour market returns to these English and Maths qualifications, in two different situations: • Complementary Learning i.e. when combined with higher level qualifications • Highest Learning Aim - when they are studied as a person’s highest FE qualification (i.e. not taken with a higher qualification

The Impact Of Skills And Training Interventions On The Unemployed: Phase II Report

This report is the latest in a series of studies that analyse the returns to FE learning using matched ILR-WPLS administrative data. A recent study in this series (Bibby et. al. 2014) uses the matched data to produce robust estimates of the labour market returns to achievement of learning aims whilst studying in English Further Education (FE), relative to those who have the same highest learning aim, but do not achieve. Whilst survey-based studies had suggested that some vocational qualifications (for instance, NVQ2) were associated with negligible, or even negative, earnings returns; Bibby et. al find that FE qualifications are associated with good labour market returns. The authors provide compelling evidence that the previous less favourable findings at Level 2 were a result of data limitations, rather than truly insignificant value added. This report investigates labour market returns for a specific subgroup within the wider populations that form the focus of study within this ongoing programme of research. We identify the returns to FE Learning for the unemployed in England. For this study it is essential to use an approach to estimation of value added that is appropriate for learning at Level 2 and below, as many of the interventions targeted at the unemployed are at this level

Estimating earnings returns to vocational qualifications using administrative data

In this paper we update the findings from Buscha and Urwin (2013), estimating separately the (i) earnings, (ii) employment probability and (iii) probability of being on active benefits, for those who achieve their highest learning aim whilst studying at an English Further Education Institution (FEI), relative to those who have the same highest learning aim, but do not achieve. Estimates are obtained using the 2002-2012 ILR-WPLS administrative dataset, and the findings provide a robust estimate of the value added from each qualification, when held as an individual’s highes

Further Education: Social Mobility, Skills and Second Chances

This report looks at data analysis which has uncovered good returns to learning at all levels of FE and challenges previous findings from survey-based studies that estimated insignificant, or even negative, returns to learning at level 2 and below. In the accompanying policy comment Professor Peter Unwin from the Centre welcomes the recent move away from the almost exclusive focus on more academic learning within HE over recent decades to a focus on apprenticeship learning. He argues that some of the greatest opportunities for boosting UK productivity will only be achieved if we can unlock the potential of those who have innate ability, but are not able to make the most of this, as they are born to levels of disadvantage that mean they are more likely to give up on education at an early age. FE, he argues, takes the most disadvantaged on the longest educational journeys

Industrial policy evaluation in the presence of spillovers

The shortage of studies on spatial spillovers of capital subsidy policies is rather surprising, considering that such policies are usually designed to generate spatial externalities. We propose a new framework that allows positive agglomeration effects to be contrasted with the negative cross-sectional substitution and the crowding-out effect. The global evaluation of the ATT and the spillover parameters shifts the spotlight from the policy effect on subsidised firms to the global effect of capital subsidy policies on the targeted territory. The empirical evaluation of a policy in Italy mainly directed towards small- and medium-sized firms shows that the impact on investments, turnover and employment is positive and large, but is negative on TFP. However, the employment growth is partially determined to the detriment of the untreated firms

Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis

S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P1-5). Increasing numbers of studies have indicated the importance of S1P3 in various pathophysiological processes. Recently, we have identified a pepducin (compound KRX- 725-II) acting as an S1P3 receptor antagonist. Here, aiming to optimize the activity and selectivity profile of the described compound, we have synthesized a series of derivatives in which Tyr, in position 4, has been substituted with several natural aromatic and unnatural aromatic and nonaromatic amino acids. All the compounds were evaluated for their ability to inhibit vascular relaxation induced by KRX-725 (as S1P3 selective pepducin agonist) and KRX-722 (an S1P1-selective pepducin agonist). Those selective towards S1P3 (compounds V and VII) were also evaluated for their ability to inhibit skeletal muscle fibrosis. Finally, molecular dynamics simulations were performed to derive information on the preferred conformations of selective and unselective antagonists

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.

Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (27a), which allosterically inhibits 5-LOX, being considerably more potent than endogenous LCMs in human primary immune cells and blood. Other enzymes within lipid mediator biosynthesis were not substantially inhibited, except for microsomal prostaglandin E2 synthase-1. Compound 27a is metabolized by sulfation and β-oxidation in human liver-on-chips and exhibits superior metabolic stability in mice over LCMs. Pharmacokinetic studies show distribution of 27a from plasma to the inflamed peritoneal cavity and lung. In parallel, 5-LOX-derived leukotriene levels decrease, and the inflammatory reaction is suppressed in reconstructed human epidermis, murine peritonitis, and experimental asthma in mice. Our study highlights 27a as an orally active, LCM-inspired drug candidate that limits inflammation with superior potency and metabolic stability to the endogenous lead