Assessment of male football players’ physical fitness levels based on certain gene (AGT rs699 & IL-6 rs1800795) polymorphisms

Background: The present investigation aims to elucidate the physical fitness attributes inherent in male football players about the Angiotensinogen (AGT) rs699 and Interleukin-6 (IL-6) rs1800795 gene polymorphisms. Methods: Twenty-two male football players, aged 18 to 35 years, voluntarily enrolled in the study conducted within the North Macedonian Super League. Genomic DNA was extracted from oral epithelial cells. Genotyping procedures were then executed using real-time polymerase chain reaction (RT-PCR). All participants were actively involved in an intensive training program six days a week throughout the six-week pre-season preparation phase. The male football players underwent physical assessments both before and after the training program. Statistical analysis involved the use of the Paired-Sample t-Test to discern differences between the pre-test and post-test measurements of the male football players. Results: When stratifying the outcomes according to the IL-6 genotype and AGT genotype variables, statistically significant differences were not observed in Squat Jump (SJ), 5 m sprint, 30 m sprint, Counter Movement Jump (CMJ), Drop Jump (DJ) evaluations, and body fat percentage (p > 0.05). In contrast, statistically significant differences were observed in the Yo-Yo Intermittent Recovery Test Level 2 (Yo-Yo IRT 2), 10 m sprint, and One Repetition Maximum (1RM) bench press variables (Yo-Yo IRT 2: CC and CT p = 0.005, <0.001; 10 m sprint: CT p = 0.024; and 1RM bench press: CC, CT and TT p < 0.001, <0.001, 0.045, respectively). Significant differences were also identified in the Yo-Yo IRT 2, 10 m sprint, and 1RM bench press measurements (Yo-Yo IRT 2: CC, CG and GG p = 0.002, 0.021, 0.001; 10 m sprint: CC and GG p = 0.020, 0.028; and 1RM bench press: CC, GG p = 0.001, 0.001, respectively). Conclusions: In summary, the AGT rs699 and IL-6 rs1800795 gene polymorphisms may play a role in the adaptations induced by training in male football players

Recent advancements in the breeding of sorghum crop: current status and future strategies for marker-assisted breeding

Sorghum is emerging as a model crop for functional genetics and genomics of tropical grasses with abundant uses, including food, feed, and fuel, among others. It is currently the fifth most significant primary cereal crop. Crops are subjected to various biotic and abiotic stresses, which negatively impact on agricultural production. Developing high-yielding, disease-resistant, and climate-resilient cultivars can be achieved through marker-assisted breeding. Such selection has considerably reduced the time to market new crop varieties adapted to challenging conditions. In the recent years, extensive knowledge was gained about genetic markers. We are providing an overview of current advances in sorghum breeding initiatives, with a special focus on early breeders who may not be familiar with DNA markers. Advancements in molecular plant breeding, genetics, genomics selection, and genome editing have contributed to a thorough understanding of DNA markers, provided various proofs of the genetic variety accessible in crop plants, and have substantially enhanced plant breeding technologies. Marker-assisted selection has accelerated and precised the plant breeding process, empowering plant breeders all around the world

A new oxidative stress indicator: Effect of 5-hydroxytryptophan on thiol-disulfide homeostasis in exercise

PMID = 3093938

DOZ047.79: Bronchoscopic treatment of plastic bronchitis in children

Abstract Purpose Plastic bronchitis or cast bronchitis is a rare condition characterized by the formation of large gelatinous or rigid airway casts. Classification of plastic bronchitis is done by disease association and cast histology. This rare condition can cause airway obstruction and there is no standardized treatment. Here are presented two cases with plastic bronchitis treated by bronchoscopic removal of casts in our clinic. Patients Case 1: A 9-year-old boy presented with wheezing, cough, and respiratory distress. He expectorated the cast spontaneously and the cast was misdiagnosed as germinative membrane of a hydatid cyst at the previous center. Total collapse of the left hemithorax was seen on chest X-ray. Any underlying disease was not detected. The plastic-like solid structure was detected and easily extracted from the bronchial tree. Pathology results of the casts were eosinophilic mucoid casts. The patient experienced three bronchoscopic removals and had no recurrence thereafter for two years. Case 2: A 7-year-old girl presented with persistent cough and respiratory distress. The patient was referred to our center with the diagnosis of foreign body aspiration. Total collapse of the right middle and lower segment and partial collapse of the upper segment were seen on chest X-ray. Previously, she was diagnosed with reactive airway disease. The plastic-like semisolid structure was detected during bronchoscopy its extraction from the bronchial tree was not easy but was possible. Pathology results were eosinophilic mucoid and fibrinotic casts. This patient still needs bronchoscopy for cast removal after 12 bronchoscopic removals but her symptoms and bronchoscopy findings have regressed with time. Conclusion Bronchoscopic extraction of casts provides fast improvement of patients’ symptoms and postoperative chest X-rays, but recurrence of cast formation is common. Nevertheless, it is the mostly chosen therapy in the literature. Further researches in this area are required. </jats:sec