Magnetic resonance cholangiography in the assessment and management of biliary complications after OLT.

Despite advances in patient and graft management, biliary complications (BC) still represent a challenge both in the early and delayed period after orthotopic liver transplantation (OLT). Because of unspecific clinical presentation, imaging is often mandatory in order to diagnose BC. Among imaging modalities, magnetic resonance cholangiography (MRC) has gained widespread acceptance as a tool to represent the reconstructed biliary tree noninvasively, using both the conventional technique (based on heavily T2-weighted sequences) and contrast-enhanced MRC (based on the acquisition of T1-weighted sequences after the administration of hepatobiliary contrast agents). On this basis, MRC is generally indicated to: (1) avoid unnecessary procedures of direct cholangiography in patients with a negative examination and/or identify alternative complications; and (2) provide a road map for interventional procedures or surgery. As illustrated in the review, MRC is accurate in the diagnosis of different types of biliary complications, including anastomotic strictures, non-anastomotic strictures, leakage and stones

Solitary fibrous tumor of the omentum: Presentation of a case and literature review

Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) were considered, since their firsts description in the literature, as separate entities. The World Health Organization (WHO) classification of soft tissue tumors in 2013 declared the term HPC obsolete, and considered these lesions as features of the extrapleural SFT category. Herein we present a rare case of SFT originating from the great omentum. A 68 years old woman was admitted to our hospital with acute abdominal pain. Computed tomography revealed a 142 x 102 x 100 mm solid mass located in the pelvis, that simulated an adnexal lesion. An explorative laparotomy was performed, and a mass of the great omentum with a significant vascular pedicle arising from a branch of the left gastroepiploic artery was revealed. The tumor was completely resected. Microscopically it was composed by non-organized and spindle-shaped cells exhibiting atypical nuclei, arranged in short fascicles, and was diagnosed as. An extensive search was conducted in public scientific databases for published articles on the topic, with the aim to comprehensively describe the demographic, clinical, pathological and prognostic features of SFT; 60 previous cases have been identified and reviewed

Post-covid-19 arthritis and sacroiliitis: Natural history with longitudinal magnetic resonance imaging study in two cases and review of the literature

Severe acute respiratory coronavirus-2 syndrome (SARS-CoV-2) is a well-known pandemic infectious disease caused by an RNA virus belonging to the coronaviridae family. The most important involvement during the acute phase of infection concerns the respiratory tract and may be fatal. However, COVID-19 may become a systemic disease with a wide spectrum of manifestations. Herein, we report the natural history of sacroiliac inflammatory involvement in two females who developed COVID-19 infection with mild flu-like symptoms. After the infection they reported inflammatory back pain, with magnetic resonance imaging (MRI) studies showing typical aspects of sacroiliitis. Symptoms improved with NSAIDs therapy over the following months while MRI remained positive. A literature review was performed on this emerging topic. To our knowledge, this is the first MRI longitudinal study of post-COVID-19 sacroiliitis with almost one year of follow-up. Predisposing factors for the development of articular involvement are unclear but a long-lasting persistence of the virus, demonstrated by nasopharyngeal swab, may enhance the probability of altering the immune system in a favourable background

Inter-reader agreement of high-resolution computed tomography findings in patients with COVID-19 pneumonia: A multi-reader study

Purpose: To investigate the inter-reader agreement in assessing high-resolution computed tomography (HRCT) features of coronavirus disease 2019 (COVID-19) pneumonia. Method: Seventy-seven consecutive patients (mean age, 64 \ub1 15\ua0years) with mild COVID-19 pneumonia that underwent HRCT were retrospectively included. Three radiologists [two devoted to thoracic imaging (R1, R2), and one generalist (R3)] on a per-examination basis independently assessed ground-glass opacity (GGO), consolidation, and crazy-paving pattern. The extent of each feature (total feature score, TFS) was semi-quantitatively assessed, and each TFS summed up to obtain total lung score (TLS). Presence of organizing pneumonia (OP) pattern was also recorded. The inter-reader agreement was calculated with Cohen\u2019s Kappa (k) and Free-Marginal Multirater k. Multivariable analysis was run to determine whether imaging features were predictive of short-term evolution to severe disease (need for ventilation). Results: Most features showed substantial inter-reader agreement, including TLS > 6 (k = 0.69), which was an independent predictor of short-term occurrence of severe disease, regardless of the reader (OR 9\u201353.19). Consolidation TFS > 2 and OP pattern showed substantial and moderate agreement, respectively, only when comparing R1 and R2. Consolidation TFS > 2 and OP pattern were independent predictors of severe disease for R2 (OR 4.87) and R1 (OR 6), respectively. Conclusions: The inter-reader agreement for most HRCT features of COVID-19 pneumonia ranges moderate-to-substantial, though it depends on readers\u2019 experience in the case of consolidation and OP pattern

Radiation Recall Pneumonitis Anticipates Bilateral Immune-Induced Pneumonitis in Non-Small Cell Lung Cancer

Radiation recall pneumonitis (RRP) is a rare inflammatory reaction that occurs in previously irradiated fields, and it may be caused by various triggering agents. Immunotherapy has been reported to potentially be one of these triggers. However, precise mechanisms and specific treatments have not been explored yet due to a lack of data in this setting. Here, we report a case of a patient who received radiation therapy and immune checkpoint inhibitor therapy for non-small cell lung cancer. He developed first radiation recall pneumonitis and subsequently immune-checkpoint inhibitor-induced pneumonitis (IIP). After presenting the case, we discuss the currently available literature on RRP and the challenges of differential diagnosis between RRP, IIP, and other forms of pneumonitis. We believe that this case is of particular clinical value since it highlights the importance of including RRP in a differential diagnosis of lung consolidation during immunotherapy. Furthermore, it suggests that RRP might anticipate more extensive ICI-induced pneumonitis

Perfil de resistência de Aeromonas spp. isolada no fluxograma de produção do queijo minas frescal industrial e artesanal.

Resumo: Bactérias do gênero Aeromonas podem ser isoladas de amostras clínicas, alimentares e ambientais. Para os derivados lácteos a contaminação decorre da presença do agente na matéria prima utilizada para produção, ou devido a condições higiênicas insatisfatórias durante o processamento. Considerando a importância da Aeromonas spp. como patógeno emergente de doenças de origem alimentar, o uso indiscriminado de antimicrobianos nas patologias humanas, além do papel fundamental que o leite e seus derivados representam na alimentação humana, o presente estudo teve por objetivo verificar o comportamento dos isolados frente à ação de antimicrobianos de uso comum. Foram pesquisados produtos e pontos do fluxograma do processamento de derivados lácteos, que poderiam veicular o gênero Aeromonas e permitir sua ocorrência nos produtos finais, ou atuar como disseminadores do micro-organismo nas diferentes etapas do processamento do queijo Minas Frescal e do queijo Colonial. Os resultados demonstram altos níveis de resistência: 33,6% dos 98 isolados de Aeromonas spp. foram resistentes a todos os 15 antimicrobianos testados, correspondendo a 7,5% dos isolados do queijo Colonial e 51,7% do queijo Minas Frescal, ocorrendo, portanto, maior resistência entre as amostras coletadas na indústria. 100% dos isolados apresentaram resistência múltipla, resultado que revela um perfil preocupante para saúde pública. [Resistance profile of Aeromonas spp. Isolated in dairy products industry]. Abstract: Bacteria of the genus Aeromonas can be isolated from clinical, food and environmental samples. For dairy products contamination can be caused by the presence of the agent in the feedstock used for production or due to unsatisfactory hygienic conditions during processing. The present study aimed to assess Aeromonas isolates behavior in the presence of common antimicrobials, considering the importance of Aeromonas spp. as an emerging pathogen of foodborne diseases, the indiscriminate use of antimicrobials to treat human pathologies, in addition to the role that milk and its derivatives play in human feeding habits. The processing steps during dairy products manufacturing were studied looking for vulnerable points or products where Aeromonas could be present and, subsequently, either pass it to the final products or disseminate the micro-organism in different processing stages of Minas and Colonial cheeses. The results show high levels of resistance: 33.6% of 98 isolates of Aeromonas spp. were resistant to all 15 antibiotics tested, corresponding to 7.5% of the isolates from Colonial cheese and 51.7% from Minas cheese, thus showing greater resistance among the samples collected in the industry. Multiple antimicrobial resistance was verified in 100% of the isolates, which reveals a profile which is alarming for public health

Aeromonas no processamento de queijos tipos Minas Frescal e Colonial.

Resumo: Com o objetivo de estabelecer, durante o processamento do queijo Minas Frescal e Colonial os possíveis pontos de contaminação e a forma de disseminação de bactérias do gênero Aeromonas, foram analisados, quanto à presença do micro-organismo, diferentes produtos e pontos do fluxograma de produção. Para o Queijo Minas Frescal, Aeromonas spp. foram isoladas no leite cru, leite pasteurizado, ambiente de produção e nas mãos dos manipuladores. A. caviae foi a espécie mais frequentemente identificada, sendo também isoladas A. sobria e A. schubertii. Durante o processamento do queijo Colonial, as espécies A. hydrophila, A. caviae, A. sobria, A. veronii e A. jandaei foram isoladas a partir da água, mãos dos manipuladores, utensílios, leite cru e após tratamento térmico e de massa coagulada. Os resultados demonstram que o gênero Aeromonas encontra-se disseminado nas diferentes etapas do processamento de queijos, destacando-se o leite cru como principal fonte de contaminação para o processamento industrial e artesanal. [Aeromonas in processing line of Minas Frescal and Colonial cheeses]. Abstract: The aim of this study is to establish possible contamination points and dissemination forms of the bacteria genus Aeromonas during the processing of the Brazilian cheeses Minas Frescal and Colonial. Therefore, different products and production points of the process were analyzed to determine the presence of the microorganism. In Minas Frescal cheese, Aeromonas spp. was isolated in raw and pasteurized milk, in the environment and on the handlers? hands. A. caviae was the most frequently identified species, but A. sobria and A. schubertii were also isolated. During the processing of Colonial cheese, the species A. hydrophila, A. caviae, A. sobria, A. veronii and A. jandaei were isolated in the water, raw milk, after thermal treatment and curd, as well as on the handlers' hands and utensils. The results showed that the genus Aeromonas is disseminated throughout different stages of both cheese processes while the raw milk stands out as the main source of contamination in the industrial and handmade processing

Correction: The benefit of tumor molecular profiling on predicting treatments for colorectal adenocarcinomas

Corrections for article DOI: https://dx.doi.org/10.18632/oncotarget.24257.]

Correction: Does molecular profiling of tumors using the Caris molecular intelligence platform improve outcomes for cancer patients?

Corrections for article DOI: 10.18632/oncotarget.2425

Correction: Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy

Correction to article DOI: https://dx.doi.org/10.18632/oncotarget.2367