Dentin hassasiyet giderici ajanların tek aşamalı bir self-etch adezivin makaslama bağlanma dayanımına etkisi

Amaç: Bu çalışmanın amacı içerikleri farklı 12 adet dentin hassasiyet giderici ajanın (DHGA) bir self-etch adeziv rezinin makaslama bağlanma dayanımına etkisinin belirlenmesidir. Gereç ve Yöntem: Bu çalışmada kullanılmak üzere 195 adet çürüksüz daimi alt 3. molar dişin bukkal yüzeyindeki dentin dokusu açığa çıkacak şekilde mine dokusu uzaklaştırıldı. Dentin örnekleri rastgele 13 gruba ayrıldı (n=15). On iki farklı DHGA (Smart Protect, Systemp Desensitizer, Seal&Protect, Aqua-Prep F, Isodan, Gluma, BisBlock, D/Sense Crystal, UltraEZ, Colgate Sensitive Pro-  Relief, Topex ve Clinpro White Varnish) uygulama talimatlarına göre dentin yüzeylerine uygulandı. Kontrol grubuna DHGA uygulanmadı. Dentin örnekleri 14 gün boyunca 37°C’de yapay tükrük içinde bekletildi. Sonra yumuşak bir diş fırçası yardımıyla dentin yüzeyindeki kalıntılar 8-10 kez uygulanan dairesel hareketlerle uzaklaştırıldı. Clearfil Tri-S Bond (Kuraray Medical) dentin yüzeylerine uygulandıktan sonra silindirik kalıplar yardımıyla kompozit rezin (Filtek Z 250, 3M ESPE, USA) dentin yüzeyine uygulandı. Hazırlanan örnekler 24 saat boyunca distile suda, 37 ºC’de, etüvde bekletildi. Makaslama bağlanma dayanımının ölçüm testleri Universal Çekme-Basma Test Sistemi (Instron 3382, USA) kullanılarak yapıldı. Her bir grup için 3 adet dentin örneği hazırlanarak DHGA’nın dentin tübül tıkaç etkinliği SEM ile incelendi. Gruplar arasında bağlanma dayanımı yönünden farkın önemliliği Tek Yönlü Varyans Analizi (One-Way ANOVA) ve post hoc Tukey testi kullanılarak tespit edildi. p0.05). Sonuçlar: Bu in vitro çalışmada fluorür ve potasyum okzalat içeren DHGA uygulamaları tek aşamalı bir self-etch adezivin rezin-dentin makaslama bağlanma dayanım değerinde azalmaya neden olmuştur. Bunun muhtemel nedeni SEM incelemelerinde görüntülendiği gibi bu ajanların oluşturduğu dentin tübül tıkaçlarının, zayıf asiditesi olan self-etch adezivin dentin tübüllerine penetrasyonunu engellemesi olabilir

Does Platelet Mass Index Play a Role in Predicting Biochemical Recurrence in Localized Prostate Cancer?

Objective:The aim of this study is to investigate the association of preoperative platelet mass index (PMI) with tumor pathologic features and postoperative biochemical recurrence in patients undergoing radical prostatectomy due to localized prostate cancer.Materials and Methods:Data of 141 patients, who underwent radical prostatectomy for localized prostate cancer between April 2004 and April 2017, were retrospectively screened. Patient age, preoperative prostate-specific antigen (PSA) level, platelet count, mean platelet volume and PMI value, neutrophil-lymphocyte ratio (NLR), tumor grade, Gleason score, tumor volume, lymph node involvement, surgical margin positivity and biochemical recurrence at 3 months were all noted. The relationship of preoperative PMI value with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence was evaluated.Results:The mean age of the patients was 61.79±5.98 years, the mean PSA value was 9.50±6.69 ng/mL, mean PMI was 2003.91±486.69, and the mean NLR was 2.79±2.06. There was no correlation of PMI value with PSA, pathological stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity, and biochemical recurrence. There was statistically significant negative correlation between PMI and Gleason score.Conclusion:In our study, we could not demonstrate preoperative PMI as a prognostic factor for early biochemical recurrence in patients undergoing radical prostatectomy for prostate cancer. To achieve a better conclusion that we can generalize, there is a need for prospective studies with larger patient series

Five-Years Tigecycline Experience an Analysis of Real-Life Data

Aim: Tigecycline has been approved by the Food and Drug Administration for the treatment of complicated intra-abdominal infections, skin and soft tissue infections and community-acquired pneumonia. In our study, we examined the efficacy of tigecycline in clinical practice and reported real life data from our hospital over a period of five years. Methods: The study was conducted between 2008 and 2013 on patients who received tigecycline for longer than 48 hours in Ankara Training and Research Hospital. Clinical success was defined as clinical recovery and microbiological cure in patients who used tigecycline. Any reason for discontinuation of tigecycline treatment was considered a clinical failure. Results: In our hospital, 320 patients were administered tigecycline between 2008 and 2013. Tigecycline was mainly used for pneumonia and skin and soft tissue infections. Tigecycline was used as monotherapy in 174 patients (54.1%). The most frequently isolated agent in tigecycline-treated patients was Acinetobacter baumannii (43.4%) followed by Enterococcus (6.9%). A change in treatment was not considered necessary in 243 (75.9%) patients who received tigecycline, while it was changed in 77 patients (24.1%). Conclusion: In conclusion, the use of tigecycline can be an effective treatment choice, either as monotherapy or as a combination antibiotic therapy

West Nile Virus Infections

West Nile virus may cause a wide range of clinical presentations ranging from asymptomatic cases to fatal outcomes. Since it has been seen in Turkey and neighboring areas in recent years, it has attracted increased attention. The virus can cause West Nile fever and West Nile neuroinvasive disease, which includes meningitis, encephalitis and acute flaccid paralysis. Diagnosis is made by virus culture, polymerase chain reaction and ELISA. There is no specific therapy for West Nile virus infection and the principal therapy is mainly symptomatic

Citation Analysis of Turkish Librarianship Journals

A citation is one of the major measures that evaluates the scientific journals re- putability, reliability and usability in the international arena. The rate of the ci­tation of a journal is a significant criterion for that particular journals scienti­fic evaluation. Together with the scientific value of the journal, the citations used in an article are important benchmarks for the assessment of that article. In this paper, citations of peer reviewed articles from two library and information scien- ce journals which are published by Turkish professional associations and inde- xed in the international databases are going to be analyzed

Türkçe Kütüphanecilik Dergilerinin Atıf Analizi

A citation is one of the major measures that evaluates the scientific journals re- putability, reliability and usability in the international arena. The rate of the ci­tation of a journal is a significant criterion for that particular journals scienti­fic evaluation. Together with the scientific value of the journal, the citations used in an article are important benchmarks for the assessment of that article. In this paper, citations of peer reviewed articles from two library and information scien- ce journals which are published by Turkish professional associations and inde- xed in the international databases are going to be analyzed.Bilimsel dergilerin uluslararası alanda tanınırlığı, güvenirliliği ve kullanımının ölçülmesinin önemli göstergelerinden biri bu dergilere yapılan atıflardır. Bir der­ginin aldığı atıf oranı o derginin bilimsel değerlendirilmesinin önemli bir ölçütü iken, bir bilimsel makalenin değerlendirilmesinde kullanılan önemli ölçütlerden biri de o makalede kullanılan atıflar ve atıf yapılan yayınların bilimsel değerlen­dirilmesidir. Bu makalede ülkemizde meslek dernekleri tarafından yayınlanan ve uluslararası alan indekslerinde taranan iki kütüphanecilik/ bilgi ve belge yöneti­mi dergisinde yer alan hakemli makalelerde yapılan atıfların analizi yapılmakta­dı

Treatment response to oral antivirals in chronic hepatitis B patients: assessment of polymorphism in the IL-28B gene (rs809991)

Objectives: Chronic hepatitis C treatment response is strongly associated with interleukin 28B (IL-28B) single nucleotide gene polymorphism (SNP). In this study, we aimed to investigate the association of the IL-28B rs8099917 SNP with the first-year virological response in chronic hepatitis B (CHB) patients receiving antiviral treatment.Materials and Methods: We enrolled 100 CHB patients over the age of 18 years who had been on oral antiviral treatment for at least a year. IL-28B rs8099917 SNP was analyzed from the blood samples by polymerase chain reaction. The first-year virological response was investigated retrospectively.Results: No statistically significant association was found between the IL-28B rs8099917 SNP and first-year virological response (p=1.000). The mean age of patients who did not obtain a first-year virological response was significantly lower than that of those who did (p=0.022), and the median values of alanine aminotransferase (xULN) and hepatitis B virus (HBV)-DNA log(10)IU/ mL were higher (p<0.001 and p<0.001, respectively). The first year virologic response rate was significantly lower in hepatitis B e antigen-positive patients than in negative patients (p<0.001). In the multivariate model, it was found that having a high HBVDNA level was strongly linked to not having a first-year virological response (risk ratio: 1.995, 95% confidence interval 1.311-3.036, p=0.001).Conclusion: An association between IL-28B SNP and first-year virological response was not found in patients with CHB. Studies assessing different IL-28B SNPs are warranted to understand the factors affecting treatment response