Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model

WOS: 000317873300005PubMed: 23638411AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P 0.05). CONCLUSION: Subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats. Bevacizumab was more effective than ranibizumab and pegaptanib sodium

Periorbital Emphysema After Endoscopic Nasal Polyp Surgery

Periorbital and subcutaneous emphysema after transnasal endoscopic surgery are rare. Periorbital emphysema has been reported after facial trauma, dental interventions, procedures such as endoscopic sinus surgery and rhinoplasty, and due to medications such as systemic steroids. Although very rare, it may require urgent intervention because of the risk of increased intraocular pressure and impaired blood supply to the globe. The otolaryngology department requested ophthalmology consultation for a 65-year-old male patient who had severe periorbital emphysema of the right eye the day after endoscopic nasal polypectomy due to severe coughing and straining. Crepitus was detected on skin palpation and immediate intervention was performed by passing a 21-gauge needle through the skin into the subcutaneous tissue of the upper and lower eyelids to evacuate the subcutaneous air. The patient’s clinical symptoms resolved with no postoperative complications

A New Potential Cause in the Development of Toxic Anterior Segment Syndrome: Fibrin Glue

Objectives: To present a potential cause for toxic anterior segment syndrome (TASS). Materials and Methods: We report 4 cases of TASS that occurred following uneventful phacoemulsification and intraocular lens implantation. Results: The 4 cases were the first consecutive 2 cases of 2 different surgery days, 5 months apart. The most prominent sign of TASS was limbus-to-limbus corneal edema. Pain and/or intraocular pressure rise were also common. All surgical and presurgical procedures were checked after the first outbreak, whereas the second outbreak required further investigation. Fibrin glue remnants from preceding pterygium surgery with conjunctival autografting were found to be the potential cause. Despite intensive corticosteroid therapy, corneal edema did not resolve in 2 patients who underwent keratoplasty. Conclusion: TASS is a sight-threatening condition which requires thorough investigation for prevention of new cases. All steps must be carefully revised. (Turk J Ophthalmol 2014; 44: 280-3

Toksik ön segment sendromu için yeni bir etken: Fibrin Yapıştırıcı

Amaç: Toksik ön segment sendromuna (TÖSS) yol açan olası bir etkeni sunmak. Gereç ve Yöntem: Komplikasyonsuz fakoemülsifikasyon ve göz içi lensi yerleştirilmesi sonrasında TÖSS gelişen 4 olgu sunulmaktadır. Bulgular: Olgular, 5 ay ara ile iki ayrı ameliyat gününün ilk iki olgusu idi. TÖSS’nin en belirgin bulgusu limbustan limbusa uzanan kornea ödemiydi. Ağrı ve/veya göz içi basınç artışı da diğer sık bulgulardı. İlk olaydan sonra tüm cerrahi ve cerrahi öncesi basamaklar gözden geçirildi; ikinci olaydan sonra daha detaylı araştırma gerekti. Önceki ameliyat gününün son vakası olan otogreftli piterjiyum errahisinden arta kalan fibrin yapıştırıcı artıklarının sorumlu etken olduğu bulundu. Yoğun kortikosteroid tedavisine rağmen 2 hastada kornea ödemi düzelmedi ve hastalara keratoplasti yapıldı. Sonuç: TÖSS görmeyi tehdit eden bir durumdur ve yeni olguların önlenebilmesi için etkene yönelik yoğun araştırma gerektirir. Tüm basamaklar dikkatlice gözden geçirilmelidir. (Turk J Ophthalmol 2014; 44: 280-3)Objectives: To present a potential cause for toxic anterior segment syndrome (TASS). Materials and Methods: We report 4 cases of TASS that occurred following uneventful phacoemulsification and intraocular lens implantation. Results: The 4 cases were the first consecutive 2 cases of 2 different surgery days, 5 months apart. The most prominent sign of TASS was limbus-to-limbus corneal edema. Pain and/or intraocular pressure rise were also common. All surgical and presurgical procedures were checked after the first outbreak, whereas the second outbreak required further investigation. Fibrin glue remnants from preceding pterygium surgery with conjunctival autografting were found to be the potential cause. Despite intensive corticosteroid therapy, corneal edema did not resolve in 2 patients who underwent keratoplasty. Conclusion: TASS is a sight-threatening condition which requires thorough investigation for prevention of new cases. All steps must be carefully revised. (Turk J Ophthalmol 2014; 44: 280-3

A presenting as Retained Iridocorneal Angle Foreign Body Resembling to Disciform Keratitis A Case Report

Penetrating ocular trauma with intraocular foreign body is a serious injury often resulting in vision loss. Anterior chamber foreign bodies account for up to 15% of all intraocular foreign bodies. in this Article we report a case of a retained intraocular foreign body at the iridocorneal angle which was misdiagnosed as disciform keratitis due to localized corneal edema. A 55-year-old male applied to our clinic with complaints of decreased vision and redness in his left eye for one month. At the initial examination, stromal edema involving the inferior half of the cornea, epithelial microcysts, and moderate anterior chamber reaction were observed. the appearance of suspicious full thickness corneal wound at high magnification led us to perform gonioscopy. A foreign body located at the inferior iridocorneal angle was observed with Goldmann 3-mirror goniolens. the foreign body was surgically removed and two weeks after surgery corneal edema began to resolve. This interesting case showed that retained intraocular foreign body might reveal itself as non-healing corneal edema and should be kept in mind in the differential diagnosis.Göz içi yabancı cismin eşlik ettiği penetran oküler travmalar görme kaybı ile sonuçlanabilen ciddi yaralanmalardır. Göz içi yabancı cisimlerin %15 kadarı ön kamarada bulunmaktadır. Bu makalede lokalize kornea ödeminden dolayı diskiform keratit tanısı almış ve ön kamara açısında göz içi yabancı cisim tespit edilen bir olgu tanımlanmıştır. Sol gözünde görme azalması ve kızarıklık şikayeti ile başvuran 55 yaşındaki erkek olguda yapılan ilk muayenede korneanın alt yarısını etkileyen stromal ödem, epitelyal mikrokist ve orta düzeyde ön kamara reaksiyonu izlendi. Yüksek büyütmede yapılan biyomikroskobik muayenede şüpheli korneal tam kat yaralanma alanı görüldü ve gonyoskopik muayene yapılmasına karar verildi. Goldmann üç aynalı lens kullanılarak yapılan gonyoskopik muayenede alt iridokorneal açıda yabancı cisim izlendi. Yabancı cisim cerrahi olarak çıkarıldı. Cerrahiden iki hafta sonra korneal ödemde azalma izlendi.Sebebi belli olmayan kornea ödeminde ön kamarada yabancı cisim ayırıcı tanıda dikkate alınmalıdır