Telomere Biology and Cardiovascular Disease Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes

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EXTRACTION AND CYTOTOXICITY POTENTIAL OF MARIGOLD FLOWER (CALENDULA OFFICINALIS) AGAINST BREAST

The major source for lutein is marigold flower (Calendula officinalis). Lutein is a form of diesters and they are used as food colorant. They have many medicinal values and pharmacological activity. The present study deals with the extraction of lutein from the flower and the purification of compounds by thin layer chromatography and gas chromatography. The cell viability assay from the flower extract obtained was treated against breast cancer cell line (MCF 7). Thin layer chromatography was done and green color spot was observed and it was identified as lutein. GC-MS analysis was performed and these contains compounds were identified as diesters of lutein. Acetone extract was treated for cytotoxicity study against breast cancer cell line and the I

a Novel Redox Signaling Mechanism in Tumor Necrosis

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Mechanisms of Vascular Smooth Muscle Cell Migration

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Telomere Biology and Cardiovascular Disease Cellular Senescence Contribution to Atherosclerosis Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction, Lipid Metabolism, and Life Span Regulation

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Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res

Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at

A Monoclonal Antibody against the c-erbB-2 Protein Enhances the Cytotoxicity of c/5-Diamminedichloroplatinum against Human Breast and Ovarian Tumor Cell

A monoclonal antibody ("IAli 250) specific to an extracellular epitope of the c-erbB-2 protein (gplSS) inhibited the in vitro proliferation of human breast tumor cell lines that overexpress c-erbB-2 in a dosedependent manner. Treatment of cells with combinations of CM-diammedichloroplatinum (CDDP) and l'Ali 250 resulted in a significantly en hanced cytotoxic effect. This synergistic cytotoxicity was apparent over a wide range of antibody concentrations (200 pg/ml-100 «¿g/ml) including concentrations that showed no inhibitory effect alone. TAb 250 did not increase the cytotoxic effect of CDDP in a cell line exhibiting no detect able level of gpl85. Athymic mice bearing s.c. xenografts of human tumor cells expressing high levels of gpl85 showed a greatly enhanced inhibition of tumor growth when treated with TAb 250 and CDDP compared to treatment with the antibody or CDDP alone. This effect was specific inasmuch as TAb 250 did not enhance the growth-inhibitory effect of CDDP on tumor xenografts which were not expressing gplSS

Apoptosis and Heart Failure: A Critical Review of the Literature Vascular Cell Apoptosis in Remodeling, Restenosis, and Plaque Rupture

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studies using cultured cells

Reporting of sex as a variable in cardiovascula

^mie Press, New York.

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