Use of Finite Point Method for Wave Propagation in Nonhomogeneous Unbounded Domains

Wave propagation in an unbounded domain surrounding the stimulation resource is one of the important issues for engineers. Past literature is mainly concentrated on the modelling and estimation of the wave propagation in partially layered, homogeneous, and unbounded domains with harmonic properties. In this study, a new approach based on the Finite Point Method (FPM) has been introduced to analyze and solve the problems of wave propagation in any nonhomogeneous unbounded domain. The proposed method has the ability to use the domain properties by coordinate as an input. Therefore, there is no restriction in the form of the domain properties, such as being periodical as in the case of existing similar numerical methods. The proposed method can model the boundary points between phases with trace of errors and the results of this method satisfy both conditions of decay and radiation

Wave Propagation in Unbounded Domains under a Dirac Delta Function with FPM

Wave propagation in unbounded domains is one of the important engineering problems. There have been many attempts by researchers to solve this problem. This paper intends to shed a light on the finite point method, which is considered as one of the best methods to be used for solving problems of wave propagation in unbounded domains. To ensure the reliability of finite point method, wave propagation in unbounded domain is compared with the sinusoidal unit point stimulation. Results indicate that, in the case of applying stimulation along one direction of a Cartesian coordinate, the results of finite point method parallel to the stimulation have less error in comparison with the results of finite element method along the same direction with the same stimulation

NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects

This is the final version. Available from FASEB via the DOI in this record. Growing evidence supports a central role of NADPH oxidases (NOXs) in the regulation of platelets, which are circulating cells involved in both hemostasis and thrombosis. Here, the use of Nox1−/− and Nox1+/+ mice as experimental models of human responses demonstrated a critical role of NOX1 in collagen-dependent platelet activation and pathological arterial thrombosis, as tested in vivo by carotid occlusion assays. In contrast, NOX1 does not affect platelet responses to thrombin and normal hemostasis, as assayed in tail bleeding experiments. Therefore, as NOX1 inhibitors are likely to have antiplatelet effects without associated bleeding risks, the NOX1-selective inhibitor 2-acetylphenothiazine (2APT) and a series of its derivatives generated to increase inhibitory potency and drug bioavailability were tested. Among the 2APT derivatives, 1-(10H-phenothiazin-2-yl)vinyl tert-butyl carbonate (2APT-D6) was selected for its high potency. Both 2APT and 2APT-D6 inhibited collagen-dependent platelet aggregation, adhesion, thrombus formation, superoxide anion generation, and surface activation marker expression, while responses to thrombin or adhesion to fibrinogen were not affected. In vivo administration of 2APT or 2APT-D6 led to the inhibition of mouse platelet aggregation, oxygen radical output, and thrombus formation, and carotid occlusion, while tail hemostasis was unaffected. Differently to in vitro experiments, 2APT-D6 and 2APT displayed similar potency in vivo. In summary, NOX1 inhibition with 2APT or its derivative 2APT-D6 is a viable strategy to control collagen-induced platelet activation and reduce thrombosis without deleterious effects on hemostasis. These compounds should, therefore, be considered for the development of novel antiplatelet drugs to fight cardiovascular diseases in humans.British Heart FoundationAlzheimer's Research U

Moment-rotation behaviour of steel beam-to-column connections

In 2 vols.Available from British Library Document Supply Centre-DSC:DX196471 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo