Postępowanie w przypadku zatoru powietrznego tętnic wieńcowych podczas implantacji stentów wewnątrzwieńcowych

Coronary air embolism is a rare complication of cardiac catheterisation. We describe an alternative method of managing this complication which may be preferable to conventional methods. Kardiol Pol 2010; 68, 6: 716-71

One-Stage Combined Thoracic Ancient Schwannomas Total Removal and Coronary Artery Bypass

Ancient schwannoma is a rare variant of neural tumors though rarely seen in the thorax. The combination with coronary artery diseases is also rare. Here we describe a 66 year-old male who had undergone one-stage combined surgery for thoracic ancient schwannomas removal and coronary artery disease. The masses were, respectively, 13 cm in the middle mediastinum and 5 cm in diameter originating from the intercostal nerve. The tumors were successfully removed using sternotomy, and then a coronary artery bypass grafting was performed. Here we discuss this rare tumor in relation to the relevant literature

The importance of carotid artery stiffness and increased intima-media thickness in obese children

Background. Atherosclerosis that starts in childhood invariably advances during adulthood. Aim. We aimed to study the effect of obesity on main carotid artery intima-media thickness and arterial stiffness. Material and methods. A total of 78 children were studied from October 2010 to February 2011. They were divided into obese (42 – group 1) and normal (36 – group 2). All the children were subjected to physical examination, routine biochemical and haematological analysis, carotid ultrasonography and echocardiographic measurements. A detailed medical history was obtained. Body mass index (BMI) was calculated by dividing participants’ weight in kilograms by the square of their height in metres. Stiffness index β was calculated using blood pressure and diameter of the systolic and diastolic artery. Intima-media thickness was also measured. Results. The mean age of the obese and normal (control) groups were 10.12±2.12 years and 9.78±1.78 years respectively. Weight, BMI, and systolic and and diastolic blood pressure values were significantly higher in the obese group (all

Synthesis and Spectroscopic Studies of Phenanthroimidazole-Imine Derivatives and Evaluation of Their Antioxidant Activity

WOS: 000424218000017PubMed ID: 28986717The phenanthroimidazole derivatives are used in the drug industry in large scale. In this study four new phenanthroimidazole-imine derivatives were synthesized and their spectroscopic studies as well as their antioxidant behaviors were examined. Structural analyses were made by FT-IR, H-1-NMR, C-13-NMR, LC-MS spectroscopy techniques. UV-vis absorption and emission spectroscopy techniques have been used to determine the photophysical characteristics of four newly synthesized phenanthroimidazoles. The maximum absorption and emission wavelengths, molar extinction coefficients (epsilon), singlet energy levels (Es), Stokes' shift values (Delta lambda) of phenanthroimidazole-imine derivatives are given. Additionally, the antioxidant behavior of all compounds were investigated which the ascorbic acid used as standard molecule in present study.Scientific Research Funds of Manisa Celal Bayar University [2013-096]Funding for this research was provided by the project 2013-096, Scientific Research Funds of Manisa Celal Bayar Universit

A Randomized Trial of Mineral Trioxide Aggregate Cements in Primary Tooth Pulpotomies

Purpose: The purpose of this study was to compare the outcome of primary tooth pulpotomies using two different white mineral trioxide aggregate (MTA) cements and calcium hydroxide (CH)

Efectos de la rilmenidina en la función del sistema nervioso autónomo cardíaco de voluntarios sanos

Introducción y objetivos. La rilmenidina es un medicamento antihipertensivo cuyo mecanismo de acción es su efecto simpaticolítico en el sistema nervioso central. No obstante, los efectos de la rilmenidina en las funciones del sistema nervioso autónomo cardiovascular todavía no han sido definidos. El objetivo de este estudio es evaluar el efecto agudo de la rilmenidina en las funciones del sistema nervioso autónomo cardíaco mediante el uso de la variabilidad en la frecuencia cardíaca (VFC). Sujetos y método. Se incluyó en el estudio a un total de 20 varones sanos (edad media, 26 ± 3 años). El estudio tuvo un diseño de grupos cruzados con asignación aleatoria y control doble ciego, y durante su curso se administró 1 mg de rilmenidina o placebo a los participantes en días diferentes. Se determinaron los parámetros de tiempo y frecuencia de la VFC antes y 2 h después de la administración del fármaco o placebo, mientras los sujetos permanecían en decúbito supino o realizaban ejercicio con handgrip, con registros electrocardiográficos de 5 min. Resultados. La rilmenidina produjo un incremento de los intervalos R-R medios durante la fase posterior a la administración del fármaco (en comparación con la fase previa a su administración), mientras los participantes permanecían en decúbito supino (929 frente a 860 ms; p < 0,05), pero este efecto no fue observado en el grupo placebo. Sin embargo, no hubo diferencias en otros parámetros de tiempo y en ninguno de los parámetros de frecuencia (unidad de frecuencia baja [FB] normalizada, unidad de frecuencia alta [FA] normalizada y cociente FB/FA) entre ambos grupos. Además, ni la rilmenidina ni el placebo modificaron los parámetros de la VFC durante el ejercicio tipo handgrip. Conclusión. La administración de una dosis única de rilmenidina incrementó el tono vagal sin modificar la modulación vagal en decúbito supino. La ausencia de incremento del tono vagal durante el ejercicio de handgrip indica que este efecto de la rilmenidina es mínimo

Heart rate variability and turbulence to determine true coronary artery disease in patients with ST segment depression without angina during exercise stress testing

Purpose: ST segment depression without angina during an exercise stress test causes diagnostic problems, particularly in non-diabetic patients. Heart rate variability (HRV) and heart rate turbulence (HRT) are used to evaluate the changes in cardiac autonomic functions and are also both decreased in patients with coronary artery disease. The aim of this study was determine the values of HRV and HRT that discriminate true coronary artery disease from false positive stress test results. Methods: Ninety non-diabetic patients who underwent diagnostic coronary angiography (CA) due to suspected coronary artery disease after ST segment depression without angina during an exercise stress test were enrolled in the study. Prior to CA, 24 hour ambulatory electrocardiogram recordings were taken and HRV and HRT parameters were calculated. Results: Patients were divided into three groups according to the severity of their coronary lesions: (group 1 normal, group 2 non-obstructive and group 3 obstructive. There were no differences among the groups with regards to age, sex, medical history, medications, systolic and diastolic blood pressures, body mass index, fasting glucose, anemia and thyroid status, lipid profile and creatinine clearance. HRV parameters and turbulence slope (TS) were significantly lower while turbulence onset (TO) was significantly higher in group 3 than groups 1 and 2. According to the cut-off values calculated using ROC analysis, SDNN≤69.63 msec, TO > 0.14%, and TS≤2.78 msec/RR have high diagnostic accuracy for predicting obstructive coronary artery disease. Conclusion: HRV and HRT parameters may provide additional information for discriminating between patients who do and do not truly need CA

Activation of peripheral opioid receptors has no effect on heart rate variability

Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout rest, controlled breathing, or the hand grip exercise. We concluded that trimebutine, in clinical doses, has no significant effect on cardiac autonomic functions

Importance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease

WOS: 000411299900001Coronary artery disease (CAD) is the most prominent cause of mortality worldwide. The basis of CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPCI gene plays a critical role in the atherosclerosis progression. This study aimed to examine whether 644 A -> G polymorphism of NPCI is associated with the risk of coronary artery disease in Turkish patients. In this case-control study, 200 persons were studied (100 patients and 100 controls). The 644 AEG polymorphism of NPCI gene is analyzed using polymerase chain reaction and restriction fragment length polymorphism methods. There was a significant relationship between the distribution of coronary artery disease and control group in terms of allele and genotype frequency (p= 0.0002) (p=0.003), respectively. According to the researchers' results, 644 A -> G polymorphism in NPCI gene can be one of the predisposition factor to coronary artery disease in Turkish population