Reboxetina para el TDAH en niños que no responden o con mala tolerancia al metilfenidato: un estudio prospectivo abierto a largo plazo

Up to 30% of patients with attention-deficit hyperactivity disorder (ADHD) treated with psychostimulants discontinue the treatment because of intolerance or lack of therapeutic response. Therapeutic alternatives are needed for such patients. In the present case series, we study the effectiveness of reboxetine over a period of 6 months in a sample of 14 children diagnosed with ADHD according to DSM-IV-TR criteria, who had responded only partially or had presented poor tolerance to conventional treatment with methylphenidate. Clinical efficacy was evaluated through the application of the 18-item Attention-Deficit Hyperactivity Disorder Rating Scale (ADHD-RS-IV) and the Clinical Global Impressions-Global Improvement Scale (CGI-I). Percentages of responders (ADHD-RS ≥ 25%) and improvers (CGI-I absolute value < 4) were 90.9 and 72.7%, respectively. No serious side-effects were observed during treatment, the most frequent effects being headaches and insomnia. The initial findings of our study show that reboxetine may constitute an effective tool for long-term treatment of children with ADHD who present poor response or poor tolerance to initial treatment with methylphenidate.Depto. de Medicina Legal, Psiquiatría y PatologíaFac. de MedicinaTRUEpu

Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines

A series of 3-benzoyl imidazo[1,2-a]pyrimidines, obtained from N-heteroarylformamidines in good yields, was tested in silico and in vitro for binding and inhibition of seven Candida species (Candida albicans (ATCC 10231), Candida dubliniensis (CD36), Candida glabrata (CBS138), Candida guilliermondii (ATCC 6260), Candida kefyr, Candida krusei (ATCC 6358) and Candida tropicalis (MYA-3404)). To predict binding mode and energy, each compound was docked in the active site of the lanosterol 14α-demethylase enzyme (CYP51), essential for fungal growth of Candida species. Antimycotic activity was evaluated as the 50% minimum inhibitory concentration (MIC50) for the test compounds and two reference drugs, ketoconazole and fluconazole. All test compounds had a better binding energy (range: −6.11 to −9.43 kcal/mol) than that found for the reference drugs (range: 48.93 to −6.16 kcal/mol). In general, the test compounds showed greater inhibitory activity of yeast growth than the reference drugs. Compounds 4j and 4f were the most active, indicating an important role in biological activity for the benzene ring with electron-withdrawing substituents. These compounds show the best MIC50 against C. guilliermondii and C. glabrata, respectively. The current findings suggest that the 3-benzoyl imidazo[1,2-a]pyrimidine derivatives, herein synthesized by an accessible methodology, are potential antifungal drugs

Proyecto Qubbet El-Hawa: Las tumbas nº 33 y 34h. Tercera Campaña 2010.

En el presente artículo se exponen los resultados preliminares de los trabajos multidisciplinares llevados a cabo en la necrópolis de Qubbet el-Hawa (Asuán) durante el año 2010. En este sentido, se detallan los trabajos arqueológicos llevados a cabo en las tumbas 33 y 34 (ambas datadas en la Dinastía XII) y algunos estudios específicos resultantes de ellos. Se describen los primeros resultados de las labores de conservación realizados en la tumba 34h (Junes).Preliminary results of the multidisciplinary works carried out in the necropolis of Qubbet el-Hawa (Aswan) during 2010 season are detailed in the present paper. A brief account of major archaeological results from the works carried out in tombs nº 33 and 34 (both dated to the 12th Dynasty) are detailed together with specific studies derived from them. First results of the conservation measures in tomb 34h (Khunes) are described