18 research outputs found
Key Indicators of Inventive Performance for Characterizing Design Activities in R&Ds: Application in Technological Design
International audienceThis chapter is a synthesis of the contributions made by scientific authors about the evaluation of creativity and inventive activities, which aims to establish a baseline for measuring inventive performance. Although some lessons of this work have been published in a Ph.D. thesis, journals, and proceedings of international conferences, it provides an overall view of our findings during recent years in the form of a framework, namely, inventive design performance measurement system (IDPMS). The chapter introduces some new observations, citing related discussions for defining the key indicators of inventive performance. The purpose is to give a better understanding about the evaluation of creativity that leads to revising the research roadmap
DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease
Serum Levels of Caspase-Cleaved Cytokeratin-18 in Patients with Severe Traumatic Brain Injury Are Associated with Mortality: A Pilot Study
Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity
Neuronal caspase-3 signaling: not only cell death
Caspases are a family of cysteinyl aspartate-specific proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. A member of this family, caspase-3, has been identified as a key mediator of apoptosis in neuronal cells. Recent studies in snail, fly and rat suggest that caspase-3 also functions as a regulatory molecule in neurogenesis and synaptic activity. In this study, in addition to providing an overview of the mechanism of caspase-3 activation, we review genetic and pharmacological studies of apoptotic and nonapoptotic functions of caspase-3 and discuss the regulatory mechanism of caspase-3 for executing nonapoptotic functions in the central nervous system. Knowledge of biochemical pathway(s) for nonapoptotic activation and modulation of caspase-3 has potential implications for the understanding of synaptic failure in the pathophysiology of neurological disorders. Fine-tuning of caspase-3 lays down a new challenge in identifying pharmacological avenues for treatment of many neurological disorders