CFD Analysis of Helicopter Wakes in Ground Effect

The paper presents CFD results for the wake of a helicopter flying a low altitude at different advance ratios. The wakes are assessed in terms of topology and velocity magnitudes. The structure of the wake near ground changes rapidly with the advance ratio and its decay appears to be faster than what is suggested by theoretical analyses. The results show clear the potential of modern CFD for use in helicopter safety and highlights the need for detailed surveys of helicopter wakes using full-scale physical experiments

A two-rigid block model for sliding gravity retaining walls

This paper presents a new two rigid block model for sliding gravity retaining walls. Some conceptual limitations of a direct application of Newmark's sliding block method to the case of retaining walls are discussed with reference to a simple scheme of two interacting rigid blocks on an inclined plane. In particular, it is shown that both the internal force between the blocks and their absolute acceleration are not constant during sliding, and must be computed by direct consideration of the dynamic equilibrium and kinematic constraints for the whole system. The same concepts are extended to the analysis of the active soil wedge-wall system, leading to an extremely simple procedure to compute the relative displacements of the wall when subjected to base accelerations exceeding the critical value. A comparison with the results of numerical analyses demonstrates that the proposed method is capable of describing fully the kinematics of the soil wedge-wall system under dynamic loading. On the contrary, direct application of Newmark's method may lead to inaccurate predictions of the final displacements, in excess or in defect depending on a coefficient, which emerges from direct consideration of the dynamic equilibrium of the whole system. This coefficient can be viewed as a corrective factor for the horizontal relative acceleration of the wall, related to the mechanical and geometrical properties of the soil-wall system

AA/12-Lipoxygenase Signaling Contributes to Inhibitory Learning in Hermissenda Type B Photoreceptors

Conditioned inhibition (CI) is a major category of associative learning that occurs when an organism learns that one stimulus predicts the absence of another. In addition to being important in its own right, CI is interesting because its occurrence implies that the organism has formed an association between stimuli that are non-coincident. In contrast to other categories of associative learning that are dependent upon temporal contiguity (pairings) of stimuli, the neurobiology of CI is virtually unexplored. We have previously described a simple form of CI learning in Hermissenda, whereby animals’ phototactic behavior is increased by repeated exposures to explicitly unpaired (EU) presentations of light and rotation. EU conditioning also produces characteristic reductions in the excitability and light response, and increases several somatic K+ currents in Type B photoreceptors. Type B photoreceptors are a major site of plasticity for classical conditioning in Hermissenda. Because arachidonic acid (AA) and/or its metabolites open diverse K+ channels in many cell types, we examined the potential contribution of AA to CI. Our results indicate that AA contributes to one of the major effects of EU-conditioning on Type B photoreceptors: decreases in light-evoked spike activity. We find that AA increases the transient (IA) somatic K+ current in Type B photoreceptors, further mimicking CI training. In addition, our results indicate that metabolism of AA by a 12-lipoxygenase enzyme is critical for these effects of AA, and further that 12-lipoxygenase metabolites are apparently generated during CI training

Digital Servitization and Business Model Innovation in SMEs: A Model to Escape From Market Disruption

The progress and the adoption of digital technologies can rapidly make products, processes, and business models obsolete, until disrupting entire markets. In this context, small–medium enterprises (SMEs) operating in manufacturing are especially challenged due to their limited resources and smallness liabilities. Firms can implement, design, and deliver new smart and connected products that change the way they compete and trigger the provision of services—until redesigning the entire business model. However, little knowledge is available on how SMEs may effectively trigger and catalyze such transition. Using an interpretative research approach inspired by the design research methodology, in this article, we explore how SMEs may leverage digital servitization to escape from a disrupted market. Based on our findings, an original digital servitization model tailored for SMEs is proposed. Finally, the study provides a set of research and managerial implications on how SMEs can overcome market disruption in the manufacturing context through digital servitization and business model innovation

Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study.

BACKGROUND: Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA). A negative association between serum 25(OH) vitamin D levels and RA activity was demonstrated but longitudinal studies investigating the role of vitamin D levels in predicting RA activity and response to treatment are lacking. Therefore, this study was designed to test the hypothesis of an association between serum 25(OH) vitamin D levels at RA diagnosis and disease activity evaluated by clinimetric, laboratory and ultrasound (US) parameters and to detect the prevalence of remission and response to treatment after 12 months follow-up. METHODS: This is a longitudinal, retrospective study on data obtained from thirty-seven patients with early RA treatment-naïve. Serum inflammatory markers, auto-antibodies and 25(OH) vitamin D levels were obtained at baseline. Hypovitaminosis D was diagnosed for 25(OH) vitamin D levels < 20 ng/ml. Tender joint count (TJCs), swollen joint count (SJCs), Visual Analog Scales (VAS), Disease Activity Score (DAS) 28 score were assessed at baseline and 12 months after diagnosis. Joints synovitis and power-Doppler were evaluated at baseline and 12 months later. RESULTS: At baseline mean 25(OH) vitamin D levels were 24.4 ± 11.9 ng/ml; 35% of study subjects had hypovitaminosis D which strongly associated with higher RA activity and lower prevalence of remission and response to treatment (all p-values < 0.001). The percentage of patients not presenting a reduction of the US synovitis score after 12 months from diagnosis was significantly higher among patients with hypovitaminosis D than in those with normal serum 25(OH) vitamin D at baseline. CONCLUSIONS: In patients with early RA and basal hypovitaminosis D after 12 months follow-up reduction of disease activity and percentage of remission and response to treatment were significantly lower than those observed in patients with normal vitamin D levels. These results provide further support to the immunomodulatory action of vitamin D in RA and suggest a role of basal vitamin D status in the prediction of disease evolution. Vitamin D measurement and possibly vitamin D supplementation should be considered an additional option in the management of early RA patients

Extended endoscopic endonasal transsphenoidal approach to the suprasellar area: Anatomic considerations - Part I

INTRODUCTION: Interest in using the extended endonasal transsphenoidal approach for management of suprasellar lesions, with either a microscopic or endoscopic technique, has increased in recent years. The most relevant benefit is that this median approach permits the exposure and removal of suprasellar lesions without the need for brain retraction. MATERIALS AND METHODS: Fifteen human cadaver heads were dissected to evaluate the surgical key steps and the advantages and limitations of the extended endoscopic endonasal transplanum sphenoidale approach. We compared this with the transcranial microsurgical view of the suprasellar area as explored using the bilateral subfrontal microsurgical approach, and with the anatomy of the same region as obtained through the endoscopic endonasal route. RESULTS: Some anatomic conditions can prevent or hinder use of the extended endonasal approach. These include a low level of sphenoid sinus pneumatization, a small sella size with small distance between the internal carotid arteries, a wide intercavernous sinus, and a thick tuberculum sellae. Compared with the subfrontal transcranial approach, the endoscopic endonasal approach offers advantages to visualizing the subchiasmatic, retrosellar, and third ventricle areas. CONCLUSION: The endoscopic endonasal transplanum sphenoidale technique is a straight, median approach to the midline areas around the sella that provides a multiangled, close-up view of all relevant neurovascular structures. Although a lack of adequate instrumentation makes it impossible to manage all structures that are visible with the endoscope, in selected cases, the extended endoscopic endonasal approach can be considered part of the armamentarium for surgical treatment of the suprasellar area

Energy expenditure rate in level and uphill treadmill walking determined from empirical models and foot inertial sensing data

An empirical model is used for predicting the energy expenditure rate of treadmill walking from walking speed and incline, which are measured by a foot-mounted inertial sensor. The difference between values of the energy expenditure rate obtained by entering measured and true values of these variables in the model equation is less than the errors that are reported to affect model based assessments of the metabolic response to locomotion in humans

Assessment of walking features from foot inertial sensing

An ambulatory monitoring system is developed for the estimation of spatio-temporal gait parameters. The inertial measurement unit embedded in the system is composed of one biaxial accelerometer and one rate gyroscope, and it reconstructs the sagittal trajectory of a sensed point on the instep of the foot. A gait phase segmentation procedure is devised to determine temporal gait parameters, including stride time and relative stance; the procedure allows to define the time intervals needed for carrying an efficient implementation of the strapdown integration, which allows to estimate stride length, walking speed, and incline. The measurement accuracy of walking speed and inclines assessments is evaluated by experiments carried on adult healthy subjects walking on a motorized treadmill. Root-mean-square errors less than 0.18 km/h (speed) and 1.52% (incline) are obtained for tested speeds and inclines varying in the intervals [3, 6] km/h and [ 5, +15]%, respectively. Based on the results of these experiments, it is concluded that foot inertial sensing is a promising tool for the reliable identification of subsequent gait cycles and the accurate assessment of walking speed and incline

Effects of tractor passes on hydrological and soil erosion processes in tilled and grassed vineyards

Soil erosion is affected by rainfall temporal patterns and intensity variability. In vineyards, machine traffic is implemented with particular intensity from late spring to harvest, and it is responsible for soil compaction, which likely affects soil hydraulic properties, runoff, and soil erosion. Additionally, the hydraulic and physical properties of soil are highly influenced by vineyards&rsquo; inter-rows soil management. The effects on soil compaction and both hydrological and erosional processes of machine traffic were investigated on a sloping vineyard with different inter-row soil managements (tillage and permanent grass cover) in the Alto Monferrato area (Piedmont, NW Italy). During the investigation (November 2016&ndash;October 2018), soil water content, rainfall, runoff, and soil erosion were continuously monitored. Field-saturated hydraulic conductivity, soil penetration resistance, and bulk density were recorded periodically in portions of inter-rows affected and not affected by the machine traffic. Very different yearly precipitation characterized the observed period, leading to higher bulk density and lower infiltration rates in the wetter year, especially in the tilled vineyard, whereas soil penetration resistance was generally higher in the grassed plot and in drier conditions. In the wet year, management with grass cover considerably reduced runoff (&minus;76%) and soil loss (&minus;83%) compared to tillage and in the dry season. Those results highlight the need to limit the tractor traffic, in order to reduce negative effects due to soil compaction, especially in tilled inter-rows