3 research outputs found
Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment
The aim of this study was to investigate antioxidant enzyme activities and
lipid peroxidation levels after systemic corticoid therapy (Solu-Medrol,
250mg/day, for 7 days). The effects of corticoid treatment on superoxide
dismutase (SOD) and glutathione peroxidase (GPX) activity were investigated.
Fifteen patients diagnosed with sudden sensorineural hearing loss were
enrolled. Serum markers of oxidative stress were measured using
spectrophotometric methods. In ten cases, the SOD and GPX activities and
malondialdehyde (MDA) serum levels before and after corticoid treatment were
investigated. Corticoid treatment enhanced antioxidant activity by increasing
SOD and GPX activities and decreasing MDA serum levels