Optical Force Transducer

info:eu-repo/semantics/publishe

Capteur de force en chirurgie endoluminale

info:eu-repo/semantics/publishe

Production of optical waveguide in planar glass substrate fabricated with femtoprint

info:eu-repo/semantics/publishe

Fabrication of an optical waveguide using the femtoprint process

info:eu-repo/semantics/nonPublishe

Production of optical waveguides in planar glass substrate fabricated with Femtoprint

info:eu-repo/semantics/publishe

Synthesis of an optical waveguide in bulk silica with a femtosecond laser inscription and wet etching treatment

info:eu-repo/semantics/nonPublishe

Cancer biomarker sensing using packaged plasmonic optical fiber gratings :towards in vivo diagnosis

This work presents the development of an innovative plasmonic optical fiber (OF) immunosensor for the detection of cytokeratin 17 (CK17), a biomarker of interest for lung cancer diagnosis. The development of this sensing platform is such that it can be assessed in non-liquid environments, demonstrating that a surface plasmon resonance (SPR) can be excited in this case. For this purpose, detections have been first carried out on CK17 encapsulated in gel matrix in the aim of mimicking tissue samples. Gold-coated OF immunosensors were embedded in a specifically designed packaging providing enough stiffness to penetrate into soft matters. Resulting reflected spectra have revealed, for the first time, the presence of a stable SPR signal recorded in soft matters. Experiments conducted to detect CK17 trapped in a porous polyacrylamide gel matrix have highlighted the specific and selective biosensor response towards the target protein. Finally, the packaged OF immunosensor has been validated by a preliminary test on human lung biopsy, which has confirmed the ex-vivo CK17 detection. Consequently, this work represents an important milestone towards the detection of biomarkers in tissues, which is still a clinical challenge for minimally-invasive in vivo medical diagnosis.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Tilted fiber Bragg gratings as a new sensing device for in situ and real time monitoring of surface-initiated polymerization

The in situ and real time monitoring of surface-initiated polymerization was performed through tilted fiber Bragg gratings. The combination of gratings and stimuli responsive polymers represents a very appealing technology for the development of new sensing devices. © 2014 The Royal Society of Chemistry.SCOPUS: ar.jinfo:eu-repo/semantics/publishe