Does the Brazilian soybean production increase pose a threat on the Amazon rainforest?

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Quality of Life and psychopathology in adults who underwent Hematopoietic Stem Cell Transplantation (HSCT) in childhood: a qualitative and quantitative analysis.

Background: Patients who undergo pediatric Hematopoietic Stem Cell Transplantation (HSCT) may experience long-term psychological sequelae and poor Quality of Life (QoL) in adulthood. This study aimed to investigate subjective illness experience, QoL, and psychopathology in young adults who have survived pediatric HSCT. Method: The study involved patients treated with HSCT in the Hematology-Oncology Department between 1984 and 2007. Psychopathology and QoL were investigated using the SCL-90-R and SF-36. Socio-demographic and medical information was also collected. Finally, participants were asked to write a brief composition about their experiences of illness and care. Qualitative analysis of the texts was performed using T-LAB, an instrument for text analysis that allows the user to highlight the occurrences and co-occurrences of lemma. Quantitative analyses were performed using non-parametric tests (Spearman correlations, Kruskal-Wallis and Mann-Whitney tests). Results: Twenty-one patients (9 males) participated in the study. No significant distress was found on the SCL-90 Global Severity Index, but it was found on specific scales. On the SF-36, lower scores were reported on scales referring to bodily pain, general health, and physical and social functioning. All the measures were significantly (p < 0.05) associated with specific socio-demographic and medical variables (gender, type of pathology, type of HSCT, time elapsed between communication of the need to transplant and effective transplantation, and days of hospitalization). With regard to the narrative analyses, males focused on expressions related to the body and medical therapies, while females focused on people they met during treatment, family members, and donors. Low general health and treatment with autologous HSCT were associated with memories about chemotherapy, radiotherapy, and the body parts involved, while high general health was associated with expressions focused on gratitude (V-Test \ub1 1.96). Conclusion: Pediatric HSCT survivors are more likely to experience psychological distress and low QoL in adulthood compared with the general population. These aspects, along with survivors' subjective illness experience, show differences according to specific medical and socio-demographic variables. Studies are needed in order to improve the care and long-term follow-up of these families

Identificação do gene phlD e análise da diversidade genética em isolados de Pseudomonas spp. pertencentes ao grupo fluorescente.

RESUMO – Bactérias do gênero Pseudomonas spp. pertencentes ao grupo fluorescente têm sido mencionadas como eficazes no controle de patógenos que atacam o sistema radicular de plantas. Desse modo, este trabalho se propôs a identificar isolados de Pseudomonas spp. fluorescentes sintetizadores de 2,4-diacetilfloroglucinol (2,4- DAPG), um antibiótico que apresenta atividade contra diversos patógenos radiculares de plantas, além de avaliar a diversidade genética desse gênero de bactérias utilizando a técnica de PCR-RFLP 16S RNAr. Pela técnica de PCR foi amplificado um fragmento do gene phlD, envolvido na síntese do 2,4-DAPG. Para o PCR-RFLP, o gene ribossomal 16S foi amplificado e o produto do PCR foi digerido com a enzima de restrição AluI. De um total de 1.274 isolados analisados, seis apresentaram o gene phlD, revelando que a incidência de Pseudomonas spp. produtoras de 2,4-DAPG é baixa nos solos do Paraná. A análise da diversidade genética, realizada em 50 isolados pela comparação dos padrões de restrição do gene 16S RNAr, revelou que bactérias isoladas de diferentes culturas vegetais apresentam elevada diversidade genética, sendo identificados 11 genótipos distintos

Seleção de bactérias promotoras para produção orgânica de soja e trigo.

Errata/Autoria: BETTI, L. A

Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration

Cardiovascular diseases, including myocardial infarction (MI), represent the main worldwide cause of mortality and morbidity. In this scenario, to contrast the irreversible damages following MI, cardiac regeneration has emerged as a novel and promising solution for in situ cellular regeneration, preserving cell behavior and tissue cytoarchitecture. Among the huge variety of natural, synthetic, and hybrid compounds used for tissue regeneration, alginate emerged as a good candidate for cellular preservation and delivery, becoming one of the first biomaterial tested in pre-clinical research and clinical trials concerning cardiovascular diseases. Although promising results have been obtained, recellularization and revascularization of the infarcted area present still major limitations. Therefore, the demand is rising for alginate functionalization and its combination with molecules, factors, and drugs capable to boost the regenerative potential of the cardiac tissue. The focus of this review is to elucidate the promising properties of alginate and to highlight its benefits in clinical trials in relation to cardiac regeneration. The definition of hydrogels, the alginate characteristics, and recent biomedical applications are herewith described. Afterward, the review examines in depth the ongoing developments to refine the material relevance in cardiac recovery and regeneration after MI and presents current clinical trials based on alginate

O aumento da produção brasileira de soja representa uma ameaça para a floresta amazônica?

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Dasabuvir and Ombitasvir/Paritaprevir/Ritonavir with or without Ribavirin in Patients with HIV-HCV Coinfection. Real Life Interim Analysis of an Italian Multicentre Compassionate Use Program

Background and Aims: An HCV cure is now possible in a large proportion of HIV-HCV patient. We present real life results of a compassionate use program promoted by SIMIT (Infectious and Tropical Diseases Italian Society) of Dasabuvir and Ombitasvir/Paritaprevir/Ritonavir ± Ribavirin for 12 weeks in 213 HIV-HCV genotype 1 patients. Data on efficacy and tolerability of this strategy in HIV patients have been reported until now only in 43 non cirrhotic HIV subjects