Granularity: investigating equations that convert (T) to (D)

An investigation was done on three published expanded equations, that convert (T) to (D). T. Celio, J. Altman and M. Abouelata published equations of the same form, but with differing constants. Their equations were derived by using an assumed square-wave transmittance trace. The investigation was to find the best predictor of (D) from (T) . Both practical and simulation tests were run. The density range was extended, to check for failure at both high and low densities. Standard granularity measurement procedures were followed as close as possible. Results, from the practical tests, showed Altman \u27s equation the best predictor of (D). Celio\u27s was a close second, while Abouelata\u27s was a distant third. The simulation test, was run with normal distributions and rectangular distributions. Altman\u27s equation best fit both kinds of density distributions, as well as combinations in between the two

Sedimentation during MIS 3 at the eastern margins of the Glacial Lake Humber basin, England

The stratigraphic sequence at North Cave, on the eastern margins of the Lake Humber basin, records the deposition of a fluvioperiglacial fan (LFs 1–4), with early sedimentation (LF1) dating to Marine Isotope Stage (MIS) 3 (optically stimulated luminescence date range 41.8–38.6 ka and 14C dates 41.6–49 ka BP). Three phases of permafrost and ice wedge development during MIS 3 are evident and indicate possible fan abandonment and hence periods of reduced nival runoff. Involution structures dated to 11.1 ka with large boulders and fine‐grained sorted circles in LF4b are interpreted as periglacially cryoturbated littoral deposits with boulders derived from anchor ice, initially deposited at the margins of Lake Humber up to an altitude of 8 m OD during MIS 2. The style and age of fluvioperiglacial fan deposition at North Cave is compatible with several mid‐Devensian sites around Britain characterized by significant nival melt and run‐off from steeply incised valleys in permafrozen cuesta landscapes. This phase of fluvioperiglacial fan aggradation to near or below 0 m OD is recorded around the glacial lakes Humber and Fenland basins and indicates that no glacial lakes existed at that time

A new multi-stage recession model for Proglacial Lake Humber during the retreat of the last British-Irish Ice Sheet

The single most prominent lake associated with the retreat phase of the last British-Irish Ice Sheet (BIIS) was Proglacial Lake Humber. The present research elucidates a revised regional history of Proglacial Lake Humber from its maximum elevation to its demise using a combination of landscape mapping and luminescence dating. The results of mapping multiple Lake Humber strandlines are now best described by an eight-stage recessional model. Erosional highstands of the lake can be shown to post-date the BIIS advance that deposited the Skipsea Till at around 17 ka whereas new OSL ages show that Lake Humber was nearing its demise by 15.5±0.8 ka, indicating a possible short-lived lake. Multiple lake level stands are attributed to the switching of lake outlets from the Lincolnshire Gap to the Humber Gap and to oscillations of the BIIS blocking the latter on more than one occasion and subsequently at a lower elevation with till. The horizontal or near-horizontal shorelines confirm that isostatic adjustment did not occur during the demise of Lake Humber, indicating that BIIS advances in the North Sea region and Vale of York were not only dynamic but of short duration

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

Vocational training of disabled persons in British Columbia : a study of factors influencing the suc[c]ess of federal provincial vocational rehabilitation programmes

This study is a diagnostic descriptive study in the area of vocational rehabilitation. It reviews the operation of a particular vocational rehabilitation programme according to defined criteria of successful rehabilitation as a basis for recommendations regarding the refinement and expansion of services in the field of vocational rehabilitation. The study sample was selected from the closed cases, for 1964, of persons who had taken vocational training as arranged by the Provincial Division of Rehabilitation of British Columbia. Thirty-six case records were reviewed and analysed. In addition, letters were sent to twenty individuals out of the group whose addresses were known. Of these, eight were later interviewed. The intent of the interviews was to gain first hand information about the obstacles to successful vocational rehabilitation, based on the experiences of those who had actually participated in this vocational rehabilitation programme in British Columbia. In addition, a number of persons in the community experienced in rehabilitation work, were interviewed and contributed valuable information and insights, which were utilized in the study. The criteria for successful vocational rehabilitation used in the study were developed from the principles of rehabilitation identified in the earlier cart of the study, and included the following components: (1) full assessment (2) freedom of choice within reasonable limits allowed to the disabled person regarding courses taken (3) provision of all the necessary aids and facilities, including sufficient income to trainees, according to individual circumstances (4) provision of continuous counselling services through a designated person known to the trainee (5) assistance in job placement in the line of work for which person has trained (6) follow-up services to ensure success in holding the job for a period of at least a year. In the sample group, whose average age was about thirty, the length of the preceding period of disability, type of disability, and lack of previous employment record were not obstacles to successful rehabilitation. Out of thirty-six trainees, twenty-six completed training. In the cases of the ten who did not, the reasons for failure to do so included illness, marital and financial difficulty, and anxiety over courses, but the reasons were not known in all instances.Arts, Faculty ofSocial Work, School ofGraduat