Principles of Chemistry I & II (GA Southern)

This Grants Collection for Principles of Chemistry I & II was created under a Round Seven ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/chemistry-collections/1015/thumbnail.jp

Perturbations of the CD8+ T-cell repertoire in CVID patients with complications

AbstractA higher chronic expansion of effector cytotoxic CD8+DR+ T-lymphocytes has been reported in common variable immunodeficiency (CVID) patients with complications such as splenomegaly, autoimmune disease and/or granulomatous disease. In order to document the features associated with this T cell activation involving the CD8+ T-compartment, we examined the diversity of the alpha/beta TCR repertoire of the patient's CD8+ T-lymphocytes using the qualitative analysis of the CDR3 lengths (Immunoscope).Ten CIVD patients were enrolled in this study, four without complications (Group 1), six with complications (Group 2). All patients exhibited non-gaussian altered CDR3 length distributions, albeit to different extent within the different Vβ families. CVID patients with activated CD8+ T-cells show a reduction of their TCR repertoire diversity which is more severe in patients with complications. Viral reactivations such as CMV are suspected to be part of the mechanisms underlying immunosenescence

Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

BACKGROUND: The P-glycoprotein (P-gp), an ATP binding cassette transmembrane transporter, is expressed by astrocytes in the adult brain, and is positively modulated during astrogliosis. In a search for factors involved in this modulation, P-gp overexpression was studied in long-term in vitro astroglial cultures. RESULTS: Surprisingly, most factors that are known to induce astroglial activation in astroglial cultures failed to increase P-gp expression. The only effective proteins were IFNγ and those belonging to the IL-6 family of cytokines (IL-6, LIF, CT-1 and CNTF). As well as P-gp expression, the IL-6 type cytokines - but not IFNγ - stimulated the expression of endogenous CNTF in astrocytes. In order to see whether an increased intracellular level of CNTF was necessary for induction of P-gp overexpression by IL-6 type cytokines, by the same cytokines analysis was carried out on astrocytes obtained from CNTF knockout mice. In these conditions, IFNγ produced increased P-gp expression, but no overexpression of P-gp was observed with either IL-6, LIF or CT-1, pointing to a role of CNTF in the intracellular signalling pathway leading to P-gp overexpression. In agreement with this suggestion, application of exogenous CNTF -which is internalised with its receptor - produced an overexpression of P-gp in CNTF-deficient astrocytes. CONCLUSIONS: These results reveal two different pathways regulating P-gp expression and activity in reactive astrocytes, one of which depends upon the intracellular concentration of CNTF. This regulation of P-gp may be one of the long searched for physiological roles of CNTF

Feeding and developmental outcomes after neonatal seizures-A prospective observational study.

OBJECTIVE: Among neonates with acute symptomatic seizures, we evaluated whether inability to take full feeds at time of hospital discharge from neonatal seizure admission is associated with worse neurodevelopmental outcomes, after adjusting for relevant clinical variables. METHODS: This prospective, 9-center study of the Neonatal Seizure Registry (NSR) assessed characteristics of infants with seizures including: evidence of brainstem injury on MRI, mode of feeding upon discharge, and developmental outcomes at 12, 18, and 24 months. Inability to take oral feeds was identified through review of medical records. Brainstem injury was identified through central review of neonatal MRIs. Developmental outcomes were assessed with the Warner Initial Developmental Evaluation of Adaptive and Functional Skills (WIDEA-FS) at 12, 18, and 24 months corrected age. RESULTS: Among 276 infants, inability to achieve full oral feeds was associated with lower total WIDEA-FS scores (160.2±25.5 for full oral feeds vs. 121.8±42.9 for some/no oral feeds at 24 months, p<0.001). At 12 months, a G-tube was required for 23 of the 49 (47%) infants who did not achieve full oral feeds, compared with 2 of the 221 (1%) who took full feeds at discharge (p<0.001). CONCLUSIONS: Inability to take full oral feeds upon hospital discharge is an objective clinical sign that can identify infants with acute symptomatic neonatal seizures who are at high risk for impaired development at 24 months

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Troubles émotionnels et processus d'acceptation chez des sujets présentant un traumatisme crânien léger

Les troubles émotionnels sont fréquents chez les sujets ayant présenté un traumatisme crânien léger en raison des conséquences sociales, professionnelles et personnelles du traumatisme. Certains patients parviennent facilement à surmonter ces difficultés tandis que d'autres apparaissent bloqués par leurs émotions négatives. Ce travail vise donc a déterminer le mécanisme et les processus caractéristiques des troubles émotionnels chez ces patients afin de mettre en place une intervention ciblée et adaptée à cette population.Certificat interuniversitaire (UCL/ULG) : Psychothérapie - Intervention et évaluation psychologiques, Université catholique de Louvain, 201

Dynamic Modeling of an Activated Sludge Process: Case Study on Paper Mill Effluents

Accepté dans Journal of Environmental Engineering - ASCEInternational audienceThe aim of this paper is to propose a step by step method to establish and validate a relevant, dynamical model of the activated sludge process for paper mill industry. The model is established by considering the specificities of the effluent to be treated. It uses the Biochemical Oxygen Demand (BOD) measurement, which allows a direct correlation between the state variables of the model and the measurements. This model is validated on a pilot plant of semi-industrial size fed with industrial paper mill effluents. The parameter estimation is based on an analysis of the sensitivities. Theresults are compared with a model based on Chemical Oxygen Demand (COD) partitioning which is issued from the simplification of the Activated Sludge Model n°1 (ASM1) model. Finally, the model dealing with BOD measurements not only shows the best performances but is also the easiest to implement, overcoming one main obstacle to efficient monitoring and control in paper mill wastewater treatment plants

An efficient activated sludge model for operator support in paper mill wastewater treatment plants

http://omicron.ch.tuiasi.ro/EEMJ/International audienceIn paper processes, the variability of effluent composition and flow is impossible to predict and generally depends on the type of production method used and the manufacturing breakdowns suffered. Wastewater treatment plant operators find it difficult to maintain the efficiency of biological treatment processes. This paper focuses on activated sludge treatment modelling of paper mill wastewater to provide operators with additional support. Based on both standard activated sludge models (ASM) and those specific to pulp and paper, a number of relevant modifications are put forward so as to easily identify model parameters and obtain a validated model from the dynamic data available. Model validation is performed at a pilot plant fed with industrial effluent. Dynamic steps are applied to the process inputs (flow rates and concentrations), which induces dynamic behaviour in the biological reactor. Measurement uncertainties are taken into account in both the identification and validation steps, while theconfidence ranges for the parameters identified are estimated. Significant biological activity is indicated by the high values obtained for the parameters identified, which is confirmed by model validation. Because the size of the pilot plant is sufficient to reproduce realistic hydrodynamics, the validated model accurately describes a treatment plant's behaviour and can be used by operators as a decision-support tool

Simple synthesis of [Ru(CO3)(NHC)(p-cymene)] complexes and their use in transfer hydrogenation catalysis

A novel, efficient and facile protocol for the synthesis of a series of [Ru(NHC)(CO3)(p-cymene)] complexes is reported. This family of Ru-NHC complexes was obtained from imidazol(in)ium tetrafluoroborate or imidazolium hydrogen carbonate salts in moderate to excellent yields, employing sustainable weak base. The ruthenium complexes were successfully utilized in the transfer hydrogenation of ketones as highly active multifunctional catalysts

Paper mill wastewater treatment: model design and validation on pilot plant

International audiencePulp and paper industry discharges a very important amount of effluent, which includes a major part of carbonaceous pollution. This wastewater is usually treated by biological treatment. This paper deals with the design of a model dedicated to paper mill wastewater treatment. Validation is carried out on a real industrial effluent thanks to a semi-industrial pilot plant